Human Complement Factor B Antibody

Catalog #: MAB2739
1 Citation Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
MAB2739
MAB2739-SP

Product Details

Citations (1)

Supplemental Products

Reviews

Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Complement Factor B Antibody Summary

Species Reactivity

Human

Specificity

Detects human Complement Factor B in direct ELISAs and Western blots. Does not cross-react with recombinant human (rh) Factor D or rhFactor I.

Source

Monoclonal Mouse IgG_2B Clone # 313011

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Complement Factor B
Thr26-Leu764
Accession # P00751

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration

Sample

Western Blot

1 µg/mL

Recombinant Human Complement Factor B under non-reducing conditions only

Immunoprecipitation

25 µg/mL

Conditioned cell culture medium spiked with Recombinant Human Complement Factor B, see our available Western blot detection antibodies

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Complement Factor B

Complement Factor B, also known as C3/C5 convertase, is a serine protease of the alternative pathway of the complement system. The amino acid sequence of human Complement Factor B is 85% identical to that of rat and mouse.

Entrez Gene IDs

629 (Human); 14962 (Mouse); 294257 (Rat)

Alternate Names

BF AHUS4; BF; B-factor, properdin; BFD; C3 proaccelerator; C3 proactivator; C3/C5 convertase; CFAB; CFB; Complement Factor B; EC 3.4.21; EC 3.4.21.47; FB; FBI12; GBG; GBGCFAB; Glycine-rich beta glycoprotein; glycine-rich beta-glycoprotein; H2-Bf; PBF2; Properdin factor B

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

Citation for Human Complement Factor B Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

Bruch's Membrane Compartmentalizes Complement Regulation in the Eye with Implications for Therapeutic Design in Age-Related Macular Degeneration
Authors: SJ Clark, S McHarg, V Tilakaratn, N Brace, PN Bishop
Front Immunol, 2017-12-19;8(0):1778.

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