Human Complement Factor D/Adipsin Antibody Summary
Ile26-Ala253
Accession # P00746
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Complement Factor D/Adipsin
Complement Factor D is a serine protease that catalyzes the initial proteolytic step in the alternative pathway of complement. Expressed in adipose tissue at high levels, factor D is also known as adipsin (1). It is an exceptionally specific protease and the only known protein substrate is factor B in complex with C3 (2). Factor D protease activity is regulated by reversible conformational changes, which differs from the majority of serine proteases whose regulation involves either activation by processing of the zymogens or inactivation by binding of the inhibitors. Compared to its physiologically important proteolytic activity, factor D has much lower activity toward synthetic peptide substrates. However, thioester substrates have been routinely used for assessing factor D activity (3).
- White, R.T. et al. (1992) J. Biol. Chem. 267:9210.
- Taylor, F.R. et al. (1999) Biochemistry 38:2849.
- Kim, S. et al. (1995) J. Biol. Chem. 270:24399.
Product Datasheets
Citations for Human Complement Factor D/Adipsin Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 5
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Serum proteomic identification and validation of two novel atherosclerotic aortic aneurysm biomarkers, profilin 1 and complement factor D
Authors: Yusuke Murakami, Mitsuhiro Nishigori, Hiroaki Yagi, Tsukasa Osaki, Masaki Wakabayashi, Manabu Shirai et al.
Proteome Science
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Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models
Authors: MA Crowley, O Delgado, A Will-Orreg, NM Buchanan, K Anderson, BD Jaffee, TP Dryja, SM Liao
Invest. Ophthalmol. Vis. Sci., 2018-02-01;59(2):940-951.
Species: Rabbit
Sample Types: In Vivo
Applications: Neutralization -
Analysis of Factor D Isoforms in Malpuech-Michels-Mingarelli-Carnevale Patients Highlights the Role of MASP-3 as a Maturase in the Alternative Pathway of Complement
Authors: R Pihl, L Jensen, AG Hansen, IB Thøgersen, S Andres, F Dagnæs-Han, K Oexle, JJ Enghild, S Thiel
J. Immunol., 2017-08-09;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Western Blot -
Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function.
Authors: Degn S, Jensen L, Hansen A, Duman D, Tekin M, Jensenius J, Thiel S
J Immunol, 2012-09-10;189(8):3957-69.
Species: Human
Sample Types: Serum
Applications: Western Blot -
Potential early clinical stage colorectal cancer diagnosis using a proteomics blood test panel
Authors: Seong Beom Ahn, Samridhi Sharma, Abidali Mohamedali, Sadia Mahboob, William J. Redmond, Dana Pascovici et al.
Clinical Proteomics
FAQs
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Used this antibody as the detector in a 2-step adipsin immunoassay.
