Human Complement Factor H-related 5/
CFHR5 Antibody
Human Complement Factor H-related 5/
CFHR5 Antibody Summary
Glu19-Glu569
Accession # Q9BXR6
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Complement Factor H-related 5/CFHR5
Complement factor H-related protein 5 (FHR-5 or CFHR5) is a 65 kDa member of the factor H-related protein family. It is secreted by the liver and circulates either free or bound to HDL. It is unique among FHR proteins in that it associates with complexes that arise from complement activation. It promotes C3b cleavage and blocks C3 convertase activity. Human CFHR5 is 551 amino acids (aa) in length. It contains nine, 60 aa SUSHI-, or short consensus repeats, plus 18 intrachain disulfide bonds. SUSHI repeats 5-7 (aa 267-444) reportedly mediate CFHR5 binding to CRP and heparin. The complement interaction site(s) is unknown. Human CFHR5 shares 64% aa sequence identity with canine CFHR5.
Product Datasheets
Citations for Human Complement Factor H-related 5/
CFHR5 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism
Authors: Iglesias, MJ;Sanchez-Rivera, L;Ibrahim-Kosta, M;Naudin, C;Munsch, G;Goumidi, L;Farm, M;Smith, PM;Thibord, F;Kral-Pointner, JB;Hong, MG;Suchon, P;Germain, M;Schottmaier, W;Dusart, P;Boland, A;Kotol, D;Edfors, F;Koprulu, M;Pietzner, M;Langenberg, C;Damrauer, SM;Johnson, AD;Klarin, DM;Smith, NL;Smadja, DM;Holmström, M;Magnusson, M;Silveira, A;Uhlén, M;Renné, T;Martinez-Perez, A;Emmerich, J;Deleuze, JF;Antovic, J;Soria Fernandez, JM;Assinger, A;Schwenk, JM;Souto Andres, JC;Morange, PE;Butler, LM;Trégouët, DA;Odeberg, J;
Nature communications
Species: Human
Sample Types: Plasma, Recombinant Protein
Applications: ELISA, Western Blot, Mass Spectrometry -
FHR-5 Serum Levels and CFHR5 Genetic Variations in Patients With Immune Complex-Mediated Membranoproliferative Glomerulonephritis and C3-Glomerulopathy
Authors: Nóra Garam, Marcell Cserhalmi, Zoltán Prohászka, Ágnes Szilágyi, Nóra Veszeli, Edina Szabó et al.
Frontiers in Immunology
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Complement Factor H-Related 5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-Surfaces.
Authors: Chen Q, Manzke M, Hartmann A, Buttner M, Amann K, Pauly D, Wiesener M, Skerka C, Zipfel P
J Am Soc Nephrol, 2015-10-02;27(5):1413-25.
Species: Human
Sample Types: Cell Lysates, Whole Cells
Applications: ICC, Western Blot -
Factor H-related protein 5 interacts with pentraxin 3 and the extracellular matrix and modulates complement activation.
Authors: Csincsi A, Kopp A, Zoldi M, Banlaki Z, Uzonyi B, Hebecker M, Caesar J, Pickering M, Daigo K, Hamakubo T, Lea S, Goicoechea de Jorge E, Jozsi M
J Immunol, 2015-04-08;194(10):4963-73.
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