Human CRIM1 Antibody Summary
Leu35-Ser939
Accession # Q9NZV1
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CRIM1
Cysteine rich motor neuron 1 (CRIM1) is a type I transmembrane glycoprotein of the chordin-like cysteine-rich repeat (CRR) family of BMP inhibitors (1 - 4). The ~130 kDa, 1036 amino acid (aa) CRIM1 contains a 34 aa signal sequence, a 905 aa extracellular domain (ECD), a 21 aa transmembrane domain and a 76 aa cytoplasmic domain. The ECD includes an N-terminal IGF-binding protein-like motif and six chordin-like von Willebrand C-type CRRs. The ECD can be released from the cell, presumably by proteolytic processing (4). Human CRIM1 ECD shows 88%, 88%, 91%, 86%, 87%, 83%, and 72% aa identity with mouse, rat, dog, cow, opossum, chick, and zebrafish CRIM1 ECD, respectively. CRIM1 can interact with TGF-beta family ligands, including BMPs 2, 4, and 7, via its CRR domains (4). It binds BMPs intracellularly and antagonizes them by lowering their expression, processing and secretion (4). CRIM1 is expressed in the developing spinal cord in the floor plate and developing motor neurons (1). It is also expressed by perivascular smooth muscle cells and aligns at points of cell-cell contact during endothelial cell capillary formation (2). Endothelial cell expression in vitro appears to be specific to cells that are adherent and growing (2). CRIM1 is also expressed in a spatially and temporally restricted manner in the developing lens, limbs, kidney, teeth, and testis (5). Studies where CRIM1 expression is manipulated in developing mouse, chick, and zebrafish support its involvement in regulation of vascular and somitic development and organogenesis (5 - 7).
- Kolle, G. et al. (2000), Mech. Dev. 90:181.
- Glienke, J. et al. (2002) Mech. Dev. 119:165.
- Abreu, J.G. et al. (2002) Gene 287:39.
- Wilkinson, L. et al. (2003) J. Biol. Chem. 278:34181.
- Pennisi, D.J. et al. (2007) Dev. Dyn. 236:502.
- Kolle, G. et al. (2003) Dev. Dyn. 226:107.
- Kinna, G. et al. (2006) Mech. Dev. 123:277.
Product Datasheets
Citations for Human CRIM1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 2
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CRIM1 is localized to the podocyte filtration slit diaphragm of the adult human kidney.
Authors: Nystrom J et al.
Nephrol Dial Transplant;24(7):2038-44.
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Cytotoxicity of activated natural killer cells against pediatric solid tumors.
Authors: Cho D, Shook DR, Shimasaki N
Clin. Cancer Res., 2010-06-11;16(15):3901-9.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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