Human Dopamine D5 R/DRD5 PE-conjugated Antibody
Human Dopamine D5 R/DRD5 PE-conjugated Antibody Summary
Met1-His477
Accession # P21918
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
![Detection of Dopamine D5 R/DRD5 antibody in HEK293 Human Cell Line Transfected with Human Dopamine D5 R/DRD5 and eGFP antibody by Flow Cytometry. Detection of Dopamine D5 R/DRD5 antibody in HEK293 Human Cell Line Transfected with Human Dopamine D5 R/DRD5 and eGFP antibody by Flow Cytometry.](https://resources.rndsystems.com/images/datasheets/antibody/Dopamine_D5_R_FAB82861P_Flow_Cytometry_15954.jpg)
Detection of Dopamine D5 R/DRD5 in HEK293 Human Cell Line Transfected with Human Dopamine D5 R/DRD5 and eGFP by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with (A) human Dopamine D5 R/DRD5 or (B) irrelevant transfectants and eGFP was stained with Mouse Anti-Human Dopamine D5 R/DRD5 PE-conjugated Monoclonal Antibody (Catalog # FAB82861P). Quadrant markers were set based on control antibody staining (Catalog # IC003P). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: Dopamine D5R/DRD5
DRD5, also known as Dopamine D5 Receptor has a higher affinity for neurotransmitter dopamine than DRD1 (1). DRD5 is expressed in neurons in many human brain regions, including cortex regions, hippocampus, choroid plexus, and brainstem (2). Polymorphisms in the DRD5 gene have been associated with Attention Deficit Hyperactivity Disorder (ADHD) (3), schizopherenia (4) and nicotine dependence (5). Dopamine receptors undergo endocytosis upon interaction with receptor agonists and by activation of protein kinase C (PKC) (6).
- Sunahra, R. et al. (1991) Nature. 350:614.
- Weinshank, R. et al. (1991) J Biol Chem. 266:22427.
- Squassina, A. et al. (2008) Neurosci Lett. Feb 13.
- Golimbet, V. et al. (2008) Bull Exp Biol Med. Jan.
- Wei, J. et al. (2012) Addict Behav. 37:622.
- Thompson, D. et al. (2011) Traffic. 12:644.
Product Datasheets
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