Human EDA-A2/Ectodysplasin A2 Antibody Summary
Ala179-Ser389
Accession # NP_001005609
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: EDA-A2/Ectodysplasin A2
EDA-A2, a product of the EDA gene (also called Tabby), is a type II transmembrane protein that is a member of the TNF Superfamily (TNFSF). Human EDA-A2 is a 389 amino acid (aa) protein with a predicted N-terminal 39 aa cytoplasmic domain, a 22 aa transmembrane domain and a C-terminal 328 aa extracellular domain. The extracellular domains of human and mouse EDA-A2 share approximately 94% identity. Within the TNFSF, EDA-A2 shares the highest homology with EDA-A1, the other product of the EDA gene. EDA-A2 and EDA-A1 are splice variants of EDA which differ by only two amino acids. EDA-A1 contains two additional amino acids, Glu308 and Val309. Despite this minor difference, the EDA isoforms display strong receptor specificity. EDA-A1 only binds EDAR, a member of the TNF Receptor Superfamily (TNFRSF), whereas EDA-A2 binds to XEDAR, an X-linked TNFRSF family member with high homology to EDAR. Mutations in EDA-A1, EDA-A2, EDAR and XEDAR have been associated with hypohidrotic ectodermal dysplasia (HED). HED is characterized by abnormalities in hair, teeth and eccrine sweat gland morphogenesis. HED was initially found to associate with two gene loci, tabby and downless. Tabby was later identified as the gene for EDA and downless as the autosomal EDAR gene.
- Bayes, M. et al. (1998) Hum. Mol. Genet. 7:1661.
- Kere, J. et al. (1996) Nat. Genet. 13:409.
- Monreal, A.W. et al. (1998) Am. J. Hum. Genet. 63:380.
- Headon, D.J. and P.A. Overbeek (1999) Nat. Genet. 22(4):370.
- Kumar, A. et al. (2000) J. Biol. Chem. 276(4):2668.
- Monreal, A.W. et al. (1999) Nat. Genet. 22(4):366.
- Srivastava, A.K. et al. (1997) Proc. Natl. Acad. Sci. USA 94(24):13069.
- Yan, M. et al. (2000) Science 290(5491):523.
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