Human Erythropoietin R Biotinylated Antibody Summary
Pro26-Pro250
Accession # P19235
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Erythropoietin R
Erythropoietin (Epo), a glycoprotein produced primarily by the kidney, is the principal factor that regulates erythropoiesis by stimulating the proliferation and differentiation of erythroid progenitor cells. The biological effects of Epo are mediated by the erythropoietin receptor (Epo R). The genes for human and mouse Epo R have been cloned and characterized. The full-length human Epo R cDNA encodes a type I membrane-spanning protein with 508 amino acid (aa) residues (a 24 aa residue hydrophobic signal sequence, a 226 aa residue extracellular domain, a 22 aa residue transmembrane domain and a 236 aa residue cytoplasmic domain). At the protein sequence level, the human Epo R is approximately 82% identical to the mouse protein. As a result of alternative splicing of the Epo R gene, cDNA clones encoding a truncated form of the Epo R as well as the soluble form of Epo R has been found. The presence of a soluble form of the Epo R has also been detected on human sera. Recombinant soluble Epo R binds Epo with high affinity and is a potent Epo antagonist.
- Barber, D.L. and A.D. D’Andrea (1992) Seminars in Hematology 29:293.
- Youssoufian, H. et al. (1993) Blood 9:2223.
- Lodish, H.F. et al. (1995) Cold Spring Harbor Symposia on Quantitative Biology LX:93 - 104.
- Baynes, R.D. et al. (1993) Blood 82:2088.
Product Datasheets
Citations for Human Erythropoietin R Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Location and the functionality of erythropoietin receptor(s) in A2780 cells
Authors: Peter Solár, Gabriela Hrčková, Lenka Varinská, Zuzana Solárová, Ján Kriška, Ivana Uhrínová et al.
Oncology Reports
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Erythropoietin mimetic compound AGEM400(HES) binds to the same receptor as erythropoietin but displays a different spectrum of activities.
Authors: Kessler C, Greindl A, Breuer B, Haberl U, Rybka A, Emgenbroich M, Frank HG, Potgens AJ
Cytokine, 2011-12-03;57(2):226-37.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Characterization of erythropoietin receptor and erythropoietin expression and function in human ovarian cancer cells.
Authors: Jeong JY, Feldman L, Solar P, Szenajch J, Sytkowski AJ
Int. J. Cancer, 2008-01-15;122(2):274-80.
Species: Human
Sample Types: Cell Lysates, Whole Cells
Applications: ICC, Western Blot
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