Human Fibronectin Fluorescein-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Fibronectin

Human Fibronectin (FN) is a 210-220 kDa extracellular matrix protein that serves as a cornerstone for cell-matrix interactions. It is a sulfated glycoprotein 2055 amino acids (aa) in length. Along its length, it exhibits three types of repeating modules; twelve type I, two type II and 16 type III modules. There are more than 15 alternative splice variants, most in the C-terminal half of the molecule. FN circulates as a disulfide-linked homodimer, a product of hepatocytes. It also exists as a very large covalent multimer, likely the product of a wide variety of cell types. Within these multimers will be found FN-Fibrinogen, -Collagen 13 and -Mac2BP complexes. The multidomain nature of FN allows for binding of Fibrin, GAGs (HS and CS), Syndecans and Integrins alpha 5 beta 1 and alpha V beta 3. Over aa 31-2386 (full-length), human FN shares 91% aa sequence identity with mouse FN.

Product Datasheets

Related Research Areas

• Alpha Granule Soluble Molecules
• Extracellular Matrix and Related Molecules
• Extracellular Matrix Molecules
• Mesenchymal Cells and EMT
• Mesenchymal Stem Cell Markers
• Microglia Development
• Osteoblast and Osteoclast Markers
• Osteoblast Markers
• Osteocyte Markers
• Osteogenesis Markers
• Preeclampsia