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Human FPR1 Antibody

Catalog #: MAB3744
9 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB3744
MAB3744-SP
Product Details
Citations (9)
FAQs
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human FPR1 Antibody Summary

Species Reactivity
Human
Specificity
Detects human FPR1. Stains human FPR1-transfected cells but not irrelevant transfectants.
Source
Monoclonal Mouse IgG2A Clone # 350418
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
HEK293 human embryonic kidney cell line transfected with human FPR1
Met1-Lys350
Accession # NP_002020
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Flow Cytometry
2.5 µg/106 cells
Human whole blood monocytes
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: FPR1

FPR1, FPRL1, and FPRL2 constitute a group of 7-transmembrane segment chemotactic receptors that are expressed on phagocytes. FPR1 binding of bacterial N‑formyl‑methionyl peptides draws neutrophils to sites of infection and promotes degranulation. Human and mouse FPR1 share 73% amino acid sequence identity.

Long Name
Formyl Peptide Receptor 1
Entrez Gene IDs
2357 (Human); 14293 (Mouse); 292409 (Rat)
Alternate Names
fMet-Leu-Phe receptor; fMLF-R; fMLP receptor; FMLP; formyl peptide receptor 1; FPR1; FPRfMet-Leu-Phe receptor; N-formyl peptide receptor; N-formylpeptide chemoattractant receptor

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Citations for Human FPR1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

9 Citations: Showing 1 - 9
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  1. Use of the Site-Specific Retargeting Jump-In Platform Cell Line to Support Biologic Drug Discovery
    Authors: Robin Butler, David Hornigold, Ling Huang, Catherine Huntington, Tim London, Janette Dillon et al.
    J Biomol Screen
  2. Amyloid beta and its naturally occurring N-terminal variants are potent activators of human and mouse formyl peptide receptor 1
    Authors: L Busch, Z Al Taleb, YL Tsai, VTT Nguyen, Q Lu, CV Synatschke, K Endres, B Bufe
    The Journal of Biological Chemistry, 2022-10-27;0(0):102642.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  3. Intracellular formyl peptide receptor regulates na�ve CD4 T cell migration
    Authors: HY Lee, YS Jeong, M Lee, HS Kweon, YH Huh, JS Park, JE Hwang, K Kim, YS Bae
    Biochem. Biophys. Res. Commun., 2018-02-08;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  4. Recognition of bacterial signal peptides by mammalian formyl peptide receptors: a new mechanism for sensing pathogens.
    Authors: Bufe B, Schumann T, Kappl R, Bogeski I, Kummerow C, Podgorska M, Smola S, Hoth M, Zufall F
    J Biol Chem, 2015-01-20;290(12):7369-87.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  5. The formyl peptide receptor 1 exerts a tumor suppressor function in human gastric cancer by inhibiting angiogenesis.
    Authors: Prevete N, Liotti F, Visciano C, Marone G, Melillo R, de Paulis A
    Oncogene, 2014-09-29;34(29):3826-38.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  6. Reduced expression of chemoattractant receptors by polymorphonuclear leukocytes in Hyper IgE Syndrome patients.
    Authors: Mintz R, Garty BZ, Meshel T, Marcus N, Katanov C, Cohen-Hillel E, Ben-Baruch A
    Immunol. Lett., 2009-12-11;130(1):97-106.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  7. Syk expression in peripheral blood leukocytes, CD34+ progenitors, and CD34-derived basophils.
    Authors: Ishmael SS, MacGlashan DW
    J. Leukoc. Biol., 2009-11-04;87(2):291-300.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  8. Formyl Peptide Receptor-1 Blockade Prevents Receptor Regulation by Mitochondrial Danger-Associated Molecular Patterns and Preserves Neutrophil Function After Trauma
    Authors: Kiyoshi Itagaki, Elzbieta Kaczmarek, Woon Yong Kwon, Li Chen, Barbora Vlková, Quanzhi Zhang et al.
    Critical Care Medicine
  9. Affinity maturation of a novel antagonistic human monoclonal antibody with a long VH CDR3 targeting the Class A GPCR formyl-peptide receptor 1
    Authors: Julie A Douthwaite, Sudharsan Sridharan, Catherine Huntington, Jayne Hammersley, Rose Marwood, Jonna K Hakulinen et al.
    mAbs

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