Home / Airway Trypsin-like Protease/HAT / Human HAT (NP_004253.1) VersaClone cDNA

Human HAT (NP_004253.1) VersaClone cDNA

Catalog #: RDC3185 Datasheet / COA / SDS
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RDC3185
Human HAT (NP_004253.1) VersaClone cDNA
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Human HAT (NP_004253.1) VersaClone cDNA Summary

Specifications

Source
N/A
Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Human

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Background: Airway Trypsin-like Protease/HAT

HAT was initially purified from the sputum of patients with chronic airway diseases. Subsequent cloning revealed it as a member type II transmembrane serine proteases. HAT has been shown to induce PAR-2 mediated IL-8 release in psoriasis vulgaris and increase mucin expression in airway epithelial cells. Located in the cells of the submucosal serous glands of the bronchi and trachea, the isolated enzyme had the N-terminal sequence of ILGGTEAEEG, which corresponded to the start of the C-terminal catalytic domain (residues 187 to 418) of the deduced sequence. The N-terminal region consisted of a short cytoplasmic tail (residues 1 to 20), a transmembrane domain (residues 21 to 41), and a SEA domain (residues 44 to 164). The ectodomain of HAT is expressed and the active enzyme is purified.

Long Name
Human Airway Trypsin-like Protease
Entrez Gene IDs
9407 (Human); 231382 (Mouse)
Alternate Names
airway trypsin like protease; Airway trypsin-like protease; EC 3.4.21; EC 3.4.21.-; HAT; MGC150587; MGC150588; TMPRSS11D; transmembrane protease serine 11D; transmembrane protease, serine 11D

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