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Human HNF-4 alpha/NR2A1 Antibody

Catalog #: PP-H6939-00
10 Citations Datasheet / COA / SDS
Isoforms 7-9
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PP-H6939-00
Product Details
Citations (10)
FAQs
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human HNF-4 alpha/NR2A1 Antibody Summary

Species Reactivity
Human
Source
Monoclonal Mouse IgG1 Clone # H6939
Formulation
A liquid formulation in physiologic saline with 0.1% NaN3.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
Please refer to the PDF datasheet for specifications.
Immunohistochemistry
5-15 µg/mL
Immersion fixed paraffin-embedded sections of human large intestine
Immunoprecipitation
Please refer to the PDF datasheet for specifications.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: HNF-4 alpha/NR2A1

Hepatocyte Nuclear Factor 4 alpha (HNF4 alpha; NR2A1) is a member of the orphan nuclear receptor family. HNF4 alpha is expressed in the liver, kidney, intestine and pancreas. Mutation of HNF4 alpha in humans has been associated with maturity-onset diabetes of the young type 1 (MODY1). HNF4 binds to DNA as an exclusive homodimer. The HNF4 alpha gene is alternatively spliced and may generate up to nine different isoforms, HNF4 alpha 1 through HNF4 alpha 9. The expression of HNF-4 gamma (NR2A2) is observed in the pancreas, kidney, small intestine, and testes with no expression detected in the liver. The level of HNF-4 gamma is less 10% than that of HNF-4 alpha.

Long Name
Hepatocyte Nuclear Factor-4, alpha
Entrez Gene IDs
3172 (Human)
Alternate Names
FLJ39654; hepatic nuclear factor 4 alpha; hepatocyte nuclear factor 4, alpha; hepatocyte nuclear factor 4-alpha; HNF4 alpha; HNF-4 alpha; HNF4A; HNF4a7; HNF-4-alpha; HNF4alpha10/11/12; HNF4HNF4a8; MODY; MODY1; NR2A1; NR2A1HNF4a9; NR2A21; Nuclear receptor subfamily 2 group A member 1; TCF; TCF14; TCF-14; TCF14HNF4alpha; Transcription factor 14; Transcription factor HNF-4; transcription factor-14

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Citations for Human HNF-4 alpha/NR2A1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

10 Citations: Showing 1 - 10
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  1. Diet high in linoleic acid dysregulates the intestinal endocannabinoid system and increases susceptibility to colitis in Mice
    Authors: Poonamjot Deol, Paul Ruegger, Geoffrey D. Logan, Ali Shawki, Jiang Li, Jonathan D. Mitchell et al.
    Gut Microbes
  2. Analysis of the HNF4A isoform-regulated transcriptome identifies CCL15 as a downstream target in gastric carcinogenesis
    Authors: Zhen Ni, Wenquan Lu, Qi Li, Chuan Han, Ting Yuan, Nina Sun et al.
    Cancer Biology and Medicine
  3. CREB stimulates GPX4 transcription to inhibit ferroptosis in lung adenocarcinoma
    Authors: Z Wang, X Zhang, X Tian, Y Yang, L Ma, J Wang, Y Yu
    Oncology reports, 2021-04-13;45(6):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: ChIP
  4. Ferroptosis is governed by differential regulation of transcription in liver cancer
    Authors: X Zhang, L Du, Y Qiao, X Zhang, W Zheng, Q Wu, Y Chen, G Zhu, Y Liu, Z Bian, S Guo, Y Yang, L Ma, Y Yu, Q Pan, F Sun, J Wang
    Redox Biol, 2019-05-10;24(0):101211.
    Species: Human
    Sample Types: Cell Lysates
    Applications: ChIP, Immunoprecipitation, Proximity Ligation Assay
  5. Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity
    Authors: PR Tata, RD Chow, SV Saladi, A Tata, A Konkimalla, A Bara, D Montoro, LP Hariri, AR Shih, M Mino-Kenud, H Mou, S Kimura, LW Ellisen, J Rajagopal
    Dev. Cell, 2018-03-26;44(6):679-693.e5.
    Species: Human, Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  6. TET-Catalyzed 5-Hydroxymethylation Precedes HNF4A Promoter Choice during Differentiation of Bipotent Liver Progenitors
    Authors: PB Ancey, S Ecsedi, MP Lambert, FR Talukdar, MP Cros, D Glaise, DM Narvaez, V Chauvet, Z Herceg, A Corlu, H Hernandez-
    Stem Cell Reports, 2017-06-22;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  7. Opposing roles of nuclear receptor HNF4 alpha isoforms in colitis and colitis-associated colon cancer
    Authors: Karthikeyani Chellappa, Poonamjot Deol, Jane R Evans, Linh M Vuong, Gang Chen, Nadege Briançon et al.
    eLife
  8. Differential Effects of Hepatocyte Nuclear Factor 4 alpha Isoforms on Tumor Growth and T-Cell Factor 4/AP-1 Interactions in Human Colorectal Cancer Cells
    Authors: Linh M. Vuong, Karthikeyani Chellappa, Joseph M. Dhahbi, Jonathan R. Deans, Bin Fang, Eugene Bolotin et al.
    Molecular and Cellular Biology
  9. Mutant IDH inhibits HNF-4alpha to block hepatocyte differentiation and promote biliary cancer.
    Authors: Saha S, Parachoniak C, Ghanta K, Fitamant J, Ross K, Najem M, Gurumurthy S, Akbay E, Sia D, Cornella H, Miltiadous O, Walesky C, Deshpande V, Zhu A, Hezel A, Yen K, Straley K, Travins J, Popovici-Muller J, Gliser C, Ferrone C, Apte U, Llovet J, Wong K, Ramaswamy S, Bardeesy N
    Nature, 2014-07-02;513(7516):110-4.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  10. Novel P2 promoter-derived HNF4alpha isoforms with different N-terminus generated by alternate exon insertion.
    Authors: Huang J, Levitsky LL, Rhoads DB
    Exp. Cell Res., 2009-04-15;315(7):1200-11.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Mobility Shift Assay

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