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Human ICAM-2/CD102 Antibody

Catalog #: MAB244
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB244
MAB244-SP
Product Details
Citations (3)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human ICAM-2/CD102 Antibody Summary

Species Reactivity
Human
Specificity
Detects human ICAM‑2/CD102 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) CEACAM-1, recombinant mouse (rm) DCC, rhICAM-1, rmICAM-2, rhICAM-3, rmICAM-5, rmMAdCAM-1, rhCD31, or rmVCAM-1 is observed.
Source
Monoclonal Mouse IgG1 Clone # 86911
Purification
Protein A or G purified from ascites
Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human ICAM‑2/CD102
Lys25-Gln223 (predicted)
Accession # CAA33630
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human ICAM‑2/CD102 Fc Chimera (Catalog # 803-I2)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: ICAM-2/CD102

Intercellular Adhesion Molecule-2 (ICAM-2, CD102), a member of the immunoglobulin superfamily, binds the leukocyte integrins LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). ICAM-2 is constitutively expressed at high levels on vascular endothelial cells and lymphohematopoietic cells. ICAM-2 mediated adhesion has been shown to provide a co-stimulatory signal for T cell aggregation, NK cytotoxicity and NK cell migration.

References
  1. Somersalo, K. et al. (1995) J. Biol. Chem. 270:8629.
  2. Hayflick, J. et al. (1998) Immunologic Res. 17:313.
Long Name
Intercellular Adhesion Molecule 2
Entrez Gene IDs
3384 (Human); 15896 (Mouse)
Alternate Names
CD102 antigen; CD102; ICAM2; ICAM-2; intercellular adhesion molecule 2

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Citations for Human ICAM-2/CD102 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

3 Citations: Showing 1 - 3
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  1. An Anti-Human ICAM-1 Antibody Inhibits Rhinovirus-Induced Exacerbations of Lung Inflammation
    Authors: Stephanie Traub, Alexandra Nikonova, Alan Carruthers, Rebecca Dunmore, Katherine A. Vousden, Leila Gogsadze et al.
    PLoS Pathogens
  2. Natural killer cell-mediated shedding of ULBP2.
    Authors: Wang, Ruipeng, Sun, Peter D
    PLoS ONE, 2014-03-10;9(3):e91133.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  3. Inhibition of ICAM2 induces radiosensitization in oral squamous cell carcinoma cells.
    Authors: Ishigami T, Uzawa K, Fushimi K, Saito K, Kato Y, Nakashima D, Higo M, Kouzu Y, Bukawa H, Kawata T, Ito H, Tanzawa H
    Br. J. Cancer, 2008-03-18;98(8):1357-65.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Western Blot

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