Human IL-17/IL-17A (Research Grade Secukinumab Biosimilar) Antibody
Human IL-17/IL-17A (Research Grade Secukinumab Biosimilar) Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
Human IL‑17/IL‑17A ELISA Standard Curve Direct ELISA binding curve demonstrating the recognition of Human Anti-Human IL‑17/IL‑17A (Research Grade Secukinumab Biosimilar) Monoclonal Antibody (Catalog # MAB9492) to IL‑17/IL‑17A. The target protein was coated onto the microplate well surface, followed by binding of the antibody. A goat anti-human HRP conjugate was used for detection.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IL-17/IL-17A
Secukinumab is a humanized monoclonal IgG1/k antibody against proinflammatory cytokine IL-17A, and is approved for the treatment of plaque psoriasis, as well as enthesitis-related arthritis, and ankylosing spondylitis. Secukinumab binds to IL-17A with high specificity preventing the interaction with the IL-17 receptor and subsequent activation of the pathway leading to inflammation seen in these disease states. Data has shown that in the presence of secukinumab results in enhanced levels of free unbound IL-17A in the serum indicating inhibition of binding to IL-17A receptor resulting in reduced inflammation.
Product Datasheets
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