Human IL-17C Antibody Summary
(rh) IL‑17D and rhIL‑17E is observed.
His19-Val197
Accession # Q9P0M4
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IL-17C
The Interleukin-17 (IL-17) family proteins, comprising six members (IL-17 and IL-17B through IL-17F), are secreted, structurally related proteins that share a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus (1, 2). With the exception of IL-17B, which exists as a
non-covalently linked dimer, all IL-17 family members are disulfide-linked dimers (3). IL-17 family proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions (1, 2). Two receptors (IL-17 R, and IL-17B R), which are activated by IL-17 family members, have been identified. In addition, at least three additional orphan type I transmembrane receptors with homology to IL-17 R, including IL-17 RL (IL-17 RC), IL-17 RD, and
IL‑17 RE, have also been reported (1-4). The functions of IL-17 RC, D, and E are not known.
Human IL-17C cDNA encodes a 197 amino acid (aa) residues protein with a putative 18 aa signal peptide (5). IL-17C shares from 15-30% aa sequence identity with other IL-17 family members. Human and mouse IL-17C also share 83% aa sequence identity. IL-17C has a very restricted expression pattern and was detected as a rare expressed sequence tag (EST) sequence in an adult prostate and fetal kidney libraries (2). IL-17C has been shown to stimulate the release of TNF-alpha and IL-1 beta from the monocytic cell line THP-1, a property it shares with IL-17B (5, 6). The receptor of IL-17C has not yet been identified. The IL-17C preparations from R&D Systems have been found to bind immobilized recombinant IL-17B R/Fc in a functional ELISA.
- Aggarwal, S. and A.L. Gurney (2002) J. Leukoc. Biol. 71:1.
- Moseley, T.A. et al. (2003) Cytokine & Growth Factor Rev. 14:155.
- Hymowitz, S.G. et al. (2001) EMBO J. 20:5332.
- Haudenschild, D. et al. (2002) J. Biol. Chem. 277:4309.
- Li, H. et al. (2000) Proc. Natl. Acad. Sci. USA 97:773.
- Shi, Y. et al. (2000) J. Biol. Chem. 275:19167.
Product Datasheets
Citations for Human IL-17C Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Suppression of TCF4 promotes a ZC3H12A-mediated self-sustaining inflammatory feedback cycle involving IL-17RA/IL-17RE epidermal signaling
Authors: Jiang, Y;Gruszka, D;Zeng, C;Swindell, WR;Gaskill, C;Sorensen, C;Brown, W;Gangwar, RS;Tsoi, LC;Webster, J;Sigurdardottir, SL;Sarkar, MK;Uppala, R;Kidder, A;Xing, X;Plazyo, O;Xing, E;Billi, AC;Maverakis, E;Kahlenberg, JM;Gudjonsson, J;Ward, NL;
JCI insight
Species: Human
Sample Types: Whole Tissue
Applications: Immunohistochemistry -
Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation.
Authors: Johnston A, Fritz Y, Dawes S, Diaconu D, Al-Attar P, Guzman A, Chen C, Fu W, Gudjonsson J, McCormick T, Ward N
J Immunol, 2013-01-28;190(5):2252-62.
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