Human IL-17RA/IL-17R PE-conjugated Antibody Summary
Leu33-Trp320
Accession # Q96F46
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
View Larger
Detection of IL-17 R in K562 Human Cell Line by Flow Cytometry. K562 human chronic myelogenous leukemia cell line was stained with Mouse Anti-Human IL-17 R PE-conjugated Monoclonal Antibody (Catalog # FAB177P, filled histogram) or isotype control antibody (IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.
View Larger
Detection of IL-17RA/IL-17R by Western Blot Evaluation of IL-17 signaling in TWIST1-knockdown BC cells compared to control cells. (A) Protein levels of Act1 and IL-17RA in ShCTRL and ShTWIST cells. GAPDH was used to ensure that the same sample amounts were loaded for immunoblotting. Densitometric analysis was done using ImageJ software. (B) Levels of secreted IL-6 and IL-8 proteins in the supernatant of ShCTRL and ShTWIST cells. Data are shown as the mean (±SD). * p < 0.05. Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/34830027), licensed under a CC-BY license. Not internally tested by R&D Systems.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: IL-17RA/IL-17R
Interleukin 17 (also known as CTLA-8) is a T cell-expressed pleotropic cytokine. IL-17 binds to IL-17 receptor (IL-17 R) which shares no homology with any known family of receptors. While the expression of IL-17 is restricted to activated T cells, the IL-17 R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. Human IL-17 R is a 120 kDa, 866 amino acid (aa) type I membrane glycoprotein with a 293 aa extracellular domain, a 21 aa carboxy-proximal transmembrane domain, and a 525 aa cytoplasmic tail. Within the ECD, human IL-17 R shares 72% aa sequence identity with mouse and rat IL-17 R. The signaling events of IL-17 includes activation of NF-kappa B and JNK, and require TNF receptor-associated factors 6 (TRAF6) in the signaling pathway.
Product Datasheets
Citations for Human IL-17RA/IL-17R PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
8
Citations: Showing 1 - 8
Filter your results:
Filter by:
-
Twist1 Influences the Expression of Leading Members of the IL-17 Signaling Pathway in HER2-Positive Breast Cancer Cells
Authors: BRB Pires, R Binato, GM Ferreira, S Corrêa, B Du Rocher, D Bulzico, S Crocamo, EC Dos Santos, LG Lima, E Abdelhay
International Journal of Molecular Sciences, 2021-11-10;22(22):.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Interleukin-17A Triggers the Release of Platelet-Derived Factors Driving Vascular Endothelial Cells toward a Pro-Angiogenic State
Authors: A Gatsiou, K Sopova, A Tselepis, K Stellos
Cells, 2021-07-22;10(8):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
IL-25 dampens the growth of human germinal center-derived B-cell non Hodgkin Lymphoma by curtailing neoangiogenesis
Authors: E Ferretti, E Di Carlo, E Ognio, G Fraternali, A Corcione, B Belmonte, JL Ravetti, C Tripodo, D Ribatti, V Pistoia
Oncoimmunology, 2017-11-27;7(3):e1397249.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
IL-17A Contributes to the Pathogenesis of Endometriosis by Triggering Proinflammatory Cytokines and Angiogenic Growth Factors.
Authors: Ahn S, Edwards A, Singh S, Young S, Lessey B, Tayade C
J Immunol, 2015-08-10;195(6):2591-600.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
IL-17 Enhances Chemotaxis of Primary Human B Cells during Asthma.
Authors: Halwani, Rabih, Al-Kufaidy, Roua, Vazquez-Tello, Alejandr, Pureza, Mary Ang, BaHammam, Ahmed S, Al-Jahdali, Hamdan, Alnassar, Sami A, Hamid, Qutayba, Al-Muhsen, Saleh
PLoS ONE, 2014-12-10;9(12):e114604.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
T cell-derived IL-22 amplifies IL-1beta-driven inflammation in human adipose tissue: relevance to obesity and type 2 diabetes.
Authors: Dalmas E, Venteclef N, Caer C, Poitou C, Cremer I, Aron-Wisnewsky J, Lacroix-Desmazes S, Bayry J, Kaveri S, Clement K, Andre S, Guerre-Millo M
Diabetes, 2014-02-11;63(6):1966-77.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
TH17 cytokines induce human airway smooth muscle cell migration.
Authors: Chang Y, Al-Alwan L, Risse PA, Roussel L, Rousseau S, Halayko AJ, Martin JG, Hamid Q, Eidelman DH
J. Allergy Clin. Immunol., 2011-02-22;127(4):1046-53.e1-2.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Phenotypical characterization of human Th17 cells unambiguously identified by surface IL-17A expression.
Authors: Brucklacher-Waldert V, Steinbach K, Lioznov M, Kolster M, Holscher C, Tolosa E
J. Immunol., 2009-11-01;183(9):5494-501.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
FAQs
No product specific FAQs exist for this product, however you may
View all Antibody FAQsReviews for Human IL-17RA/IL-17R PE-conjugated Antibody
There are currently no reviews for this product. Be the first to review Human IL-17RA/IL-17R PE-conjugated Antibody and earn rewards!
Have you used Human IL-17RA/IL-17R PE-conjugated Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
