Does this Biosimilar antibody have the same sequence as the therapeutic antibody?

Name: Human IL-17RA/IL-17R (Research Grade Brodalumab Biosimilar) Antibody
Brand: R&D Systems
SKU: MAB10547
Price: 429 USD

The Biosimilar antibody has the same variable region and constant region sequence as the therapeutic antibody, except for Catalog numbers MAB9677, MAB9575, MAB9577, MAB9589, and their conjugates. These four antibodies have the same variable region as the Biosimilar, but not the same constant region.

Human IL-17RA/IL-17R (Research Grade Brodalumab Biosimilar) Antibody

Catalog #: MAB10547 Datasheet / COA / SDS

Recombinant Monoclonal Antibody For Research Use Only

Catalog #	Availability	Size / Price	Qty
MAB10547-100
MAB10547-SP

Detection of IL-17RA/IL-17R in K562 human cell line by Flow Cytometry.

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Human IL-17RA/IL-17R (Research Grade Brodalumab Biosimilar) Antibody Summary

Species Reactivity

Human

Specificity

Detects human IL-17RA/IL-17R based on Brodalumab therapeutic antibody. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Brodalumab. This product is for research use only.

Source

Recombinant Monoclonal Human IgG₁ Clone # Hu129

Purification

Protein A or G purified from cell culture supernatant

Immunogen

Human Il-17 Receptor

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Endotoxin Level

<0.10 EU per 1 μg of the antibody by the LAL method.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Flow Cytometry

0.25 µg/10⁶ cells

K562 human myelogenous leukemia cell line

CyTOF-ready

Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry

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Detection of IL-17RA/IL-17R in K562 human cell line by Flow Cytometry. K562 human myelogenous leukemia cell line was stained with Human Anti-Human IL-17RA/IL-17R (Research Grade Brodalumab Biosimilar) Monoclonal Antibody (Catalog # MAB10547, filled histogram) or Human IgG control antibody (open histogram) followed by anti-human IgG APC-conjugated Secondary Antibody (F0135). Staining was performed using our Staining Membrane-associated Proteins protocol.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IL-17RA/IL-17R

Brodalumab is a human monoclonal antibody designed for the treatment of inflammatory diseases. Brodalumab binds to the interleukin-17 receptor and so prevents interleukin 17 (IL-17) from activating the receptor.

Long Name

Interleukin 17 Receptor

Entrez Gene IDs

23765 (Human); 16172 (Mouse); 312679 (Rat); 486759 (Canine); 101925679 (Cynomolgus Monkey)

Alternate Names

CD217 antigen; CD217; Cdw217; CDw217interleukin 17 receptor; hIL-17R; IL-17 R; IL-17 RA; IL-17 receptor A; IL17RA; IL-17RA; IL-17RAMGC10262; IL17Rinterleukin-17 receptor A; interleukin 17 receptor A

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

FAQs

Does this Biosimilar antibody have the same sequence as the therapeutic antibody?
- The Biosimilar antibody has the same variable region and constant region sequence as the therapeutic antibody, except for Catalog numbers MAB9677, MAB9575, MAB9577, MAB9589, and their conjugates. These four antibodies have the same variable region as the Biosimilar, but not the same constant region.

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