Human IL-17RB PE-conjugated Antibody Summary
Arg18-Gly289
Accession # Q9NRM6
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of IL-17 RB in K562 Human Cell Line by Flow Cytometry. K562 human chronic myelogenous leukemia cell line was stained with Mouse Anti-Human IL-17 RB PE-conjugated Monoclonal Antibody (Catalog # FAB1207P, filled histogram) or isotype control antibody (Catalog # IC0041P, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: IL-17RB
The interleukin 17 (IL-17) family of cytokines, comprising six members (IL-17, IL-17B through IL-17F), are structurally related proteins with a conserved cysteine-knot structure. These proinflammatory cytokines can induce local cytokine productions and are involved in the regulation of the immune response. The cognate receptors activated by some of these cytokines have been identified (1). Interleukin-17 B Receptor (IL-17B R), also known as IL-17Rh1, IL-17ER and EVI27, represents the second receptor of the IL-17 family of cytokines to be recognized (2-4). Human IL-17B R cDNA encodes a 502 amino acid (aa) residue type I membrane protein with a putative 17 aa signal peptide, a 275 aa extracellular domain, a 21 aa transmembrane domain and a 189 aa cytoplasmic tail. By alternative splicing, a secreted variant of IL-17B R has also been identified (4). Human and mouse IL‑17B R share 76% aa sequence identity. The human IL-17B R protein sequence is only 19.2% identical to the human IL-17 R sequence, but the two receptors share many conserved cysteine residues within their extracellular domains as well as additional conserved elements within their cytoplasmic domains. Three additional type I transmembrane receptors with homology to IL-17 R have been reported, increasing the number of the IL-17 R family members to five (5, 6). By Northern blot analysis, human IL-17B R is highly expressed in kidneys and liver but is expressed at lower levels in testes, brain, small intestine and other endocrine tissues (2-4). The expression of IL-17B R is significantly up-regulated under inflammatory conditions. IL-17 RB binds strongly to IL-17E and weakly to IL-17B. It does not bind IL-17, IL-17C, and IL-17F. Activation of IL-17B R by its ligands results in the activation of nuclear factor kappa-B (2-4).
- Aggarwal, S. and A.L. Gurney (2002) J. Leukoc. Biol. 71:1.
- Shi Y, et al. (2000) J. Biol. Chem. 275:19167.
- Lee, J, et al. (2001) J. Biol. Chem. 276:1660.
- Tian E, et al. (2000) Oncogene 19:2098.
- Haudenschild, D. et al. (2002) J. Biol. Chem. 277:4309.
- Hurst, S.D. et al. (2002) J. Immunol. 169:443.
Product Datasheets
Citations for Human IL-17RB PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 7
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IL-25 induces airway remodeling in asthma by orchestrating the phenotypic changes of epithelial cell and fibrocyte
Authors: Yao, X;Chen, Q;Wang, X;Liu, X;Zhang, L;
Respiratory research
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Crosstalk between human endometrial stromal cells and decidual NK cells promotes decidualization in�vitro by upregulating IL‑25
Authors: Yuan Zhang, Ying Wang, Xiao‑Hui Wang, Wen‑Jie Zhou, Li‑Ping Jin, Ming‑Qing Li
Molecular Medicine Reports
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IL-25 dampens the growth of human germinal center-derived B-cell non Hodgkin Lymphoma by curtailing neoangiogenesis
Authors: E Ferretti, E Di Carlo, E Ognio, G Fraternali, A Corcione, B Belmonte, JL Ravetti, C Tripodo, D Ribatti, V Pistoia
Oncoimmunology, 2017-11-27;7(3):e1397249.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses
Authors: Wei-Bei Wang, Men-Luh Yen, Ko-Jiunn Liu, Pei-Ju Hsu, Ming-Hong Lin, Pei-Min Chen et al.
Stem Cell Reports
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A Critical Role for IL-17RB Signaling in HTLV-1 Tax-Induced NF-kappa B Activation and T-Cell Transformation
Authors: Alfonso Lavorgna, Masao Matsuoka, Edward William Harhaj
PLoS Pathogens
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IL-25 in atopic dermatitis: a possible link between inflammation and skin barrier dysfunction?
Authors: Hvid M, Vestergaard C, Kemp K
J. Invest. Dermatol., 2010-09-23;131(1):150-7.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3.
Authors: Caruso R, Stolfi C, Sarra M, Rizzo A, Fantini MC, Pallone F, MacDonald TT, Monteleone G
Blood, 2009-01-07;113(15):3512-9.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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