Human IL-26/AK155 Antibody Summary
Lys22-Gln171
Accession # Q9NPH9
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IL-26/AK155
IL-26 was originally cloned from herpesvirus saimiri (HVS)-transformed T cells and named AK155 (1). It is a member of the IL-10 family of class II cytokines that signal via heterodimeric receptor complexes composed of two type I transmembrane receptor subunits (2). The human IL-26 gene has been mapped to chromosome 12q15. It encodes a 171 amino acid polypeptide with a 21 amino acid signal peptide. In addition to HVS-transformed T cells, IL-26 is also expressed in other virus transformed T cell lines, fresh peripheral mononuclear cells, activated NK cells and T cells. A mouse homologue of human IL-26 has not been identified. IL-26 binds with high-affinity to the heterodimeric complex consisting of the ligand-binding IL-20 R alpha and non ligand-binding IL-10 R beta (3). Activation of the receptor complex results in rapid phosphorylation of STAT1 and STAT3. Although the IL-26 receptor complex is highly specific for IL-26 and is not activated by other class II cytokines, the individual subunits of the IL-26 receptor complex are components in receptor complexes for other class II cytokines (1). IL-20 R alpha can form dimers with IL-20 R beta to function as signaling receptors for IL-19, IL-20, and IL-24. IL-10 R beta can complex with IL-10 R alpha, IL-22 R, and IL-28 R alpha to transduce signals for IL-10, IL-22, and the three novel IFNs (IL-28A, IL-28B and IL-29), respectively. The physiological functions of IL-26 remain to be determined. IL-26 was reported to be a homodimer in solution (1).
- Knappe. A. et al. (2000) J. Virology 74:3881.
- Renauld, J.-C. (2003) Nature Reviews Immunology 3:667.
- Sheikh, F. et al. (2004) J. Immunol. 172(4):2006.
- Unpublished data (2003) R&D Systems, Inc.
Product Datasheets
Citations for Human IL-26/AK155 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
6
Citations: Showing 1 - 6
Filter your results:
Filter by:
-
Differentiation of IL-26+ TH17 intermediates into IL-17A producers via epithelial crosstalk in psoriasis
Authors: Fries, A;Saidoune, F;Kuonen, F;Dupanloup, I;Fournier, N;Guerra de Souza, AC;Haniffa, M;Ma, F;Gudjonsson, JE;Roesner, L;Li, Y;Werfel, T;Conrad, C;Gottardo, R;Modlin, RL;Di Domizio, J;Gilliet, M;
Nature communications
Species: Human
Sample Types: Whole Tissue
Applications: Immunohistochemistry -
IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells
Authors: T Itoh, R Hatano, Y Horimoto, T Yamada, D Song, H Otsuka, Y Shirakawa, S Mastuoka, N Iwao, TM Aune, NH Dang, Y Kaneko, K Okumura, C Morimoto, K Ohnuma
Cell Death & Disease, 2021-05-21;12(6):520.
Species: Human
Sample Types: Whole Cells
Applications: ICC, PLA -
Regulation of pulmonary graft-versus-host disease by IL-26+CD26+CD4 T lymphocytes.
Authors: Ohnuma K, Hatano R, Aune T, Otsuka H, Iwata S, Dang N, Yamada T, Morimoto C
J Immunol, 2015-03-18;194(8):3697-712.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
IL-26 Is Overexpressed in Rheumatoid Arthritis and Induces Proinflammatory Cytokine Production and Th17 Cell Generation.
Authors: Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, Hoppe E, Barre B, Audran M, Bouvard B, Saint-Andre J, Jeannin P
PLoS Biol, 2012-09-25;10(9):e1001395.
Species: Human
Sample Types: Serum
Applications: ELISA Development -
The role of the novel Th17 cytokine IL-26 in intestinal inflammation.
Authors: Dambacher J, Beigel F, Zitzmann K, De Toni EN, Goke B, Diepolder HM, Auernhammer CJ, Brand S
Gut, 2008-05-15;58(9):1207-17.
Species: Human
Sample Types: Serum, Whole Tissue
Applications: ELISA Development, IHC-P -
Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2.
Authors: Sheikh F, Baurin VV, Lewis-Antes A, Shah NK, Smirnov SV, Anantha S, Dickensheets H, Dumoutier L, Renauld JC, Zdanov A, Donnelly RP, Kotenko SV
J. Immunol., 2004-02-15;172(4):2006-10.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot
FAQs
No product specific FAQs exist for this product, however you may
View all Antibody FAQsReviews for Human IL-26/AK155 Antibody
There are currently no reviews for this product. Be the first to review Human IL-26/AK155 Antibody and earn rewards!
Have you used Human IL-26/AK155 Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
