Human IL-31RA Biotinylated Antibody Summary
Ala20-Ser516
Accession # Q8NI17
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IL-31RA
The interleukin-31 receptor A subunit (IL-31 RA), also known as gp130-Like Monocyte Receptor (GLM-R or GPL), is a ~100 kDa type I transmembrane glycoprotein that is classified as being a type I cytokine receptor (1, 2). A heterodimeric complex of IL-31 RA and the oncostatin M receptor (OSM-R) functions as the signaling receptor for IL-31 (3). Both subunits are inducibly expressed throughout the myelomonocytic lineage and are upregulated by interferon-gamma and bacterial lipopolysaccharides (1‑3). IL-31 RA is also expressed on keratinocytes, dorsal root ganglia neurons, and variably on lung epithelial cells (3‑6). The 732 amino acid (aa) IL-31 RA contains a 19 aa signal sequence, a 500 aa extracellular domain (ECD), a 21 aa transmembrane domain and a 192 aa cytoplasmic domain. The ECD shares 60%, 58%, 73% and 70% aa identity with mouse, rat, canine and bovine IL-31 RA ECD, respectively. Human IL-31 receptors do not respond to mouse IL-31 (7). The ECD contains five fibronectin type III domains; the first two contain four conserved cysteine residues and a WSXWS motif common to type I cytokine receptors (2). Twelve alternately spliced human IL-31 RA isoforms are known and range in size from 356‑745 amino acids. A long (745 aa) and a short (560 aa) transmembrane form are the predominant forms, and many cell lines express both forms (8). The long form, like the 732 aa form, signals by recruiting STAT3, 5 or 1, while the short form does not recruit STATs and inhibits IL-31 signaling. The ratio of these forms and their co-expression with OSM-R determines a cell’s response to IL‑31 (8). In both humans and transgenic mice, IL-31 from skin-homing Th2 cells may contribute to the pruritis (itching) associated with nonatopic dermatitis, especially in infected skin (3, 9, 10).
- Ghilardi, N. et al. (2002) J. Biol. Chem. 277:16831.
- Diveu, C. et al. (2003) J. Biol. Chem. 278:49850.
- Dillon, S. R. et al. (2004) Nat. Immunol. 5:752.
- Chattopadhyay, S. et al. (2007) J. Biol. Chem. 282:3014.
- Perrigoue, J. G. et al. (2007) J. Exp. Med. 204:481.
- Bando, T. et al. (2006) Neuroscience 142:1263.
- Broxmeyer, H. E. et al. (2007) Exp. Hematol. 35:78.
- Diveu, C. et al. (2004) Eur. Cytokine. Netw. 15:291.
- Bilsborough, J. et al. (2006) J. Allergy Clin. Immunol. 117:418.
- Sonkoly, E. et al. (2006) J. Allergy Clin. Immunol. 117:411.
Product Datasheets
Citation for Human IL-31RA Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
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Interleukin (IL)-31 induces pro-inflammatory cytokines in human monocytes and macrophages following stimulation with staphylococcal exotoxins.
Authors: Kasraie S, Niebuhr M, Werfel T
Allergy, 2009-11-04;65(6):712-21.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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