Home / IL-38/IL-1F10 / Human IL-38/IL-1F10 Antibody

Human IL-38/IL-1F10 Antibody

Catalog #: MAB2427
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB2427
MAB2427-SP
Product Details
Citations (1)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human IL-38/IL-1F10 Antibody Summary

Species Reactivity
Human
Specificity
Detects human IL‑38/IL‑1F10 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 50% cross-reactivity with recombinant mouse IL-1F10 is observed and no cross-reactivity with recombinant human (rh) IL-1 alpha /IL-1F1 rhIL-1 beta /IL-1F2, rhIL-1ra/IL-1F3, rhIL-18/IL-1F4, rhIL-36Ra/IL‑1F5, rhIL-36 alpha /IL‑1F6, rhIL‑1F7/FIL1 zeta, rhIL-36 beta /IL-1F8, or rhIL-36 gamma /IL‑1F9 is observed.
Source
Monoclonal Rat IgG2B Clone # 316709
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
E. coli-derived recombinant human IL‑38/IL‑1F10
Met1-Trp152
Accession # Q8WWZ1
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human IL‑38/IL‑1F10

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IL-38/IL-1F10

Human IL-38, previously called IL-1F10 or IL-1HY2, is a secreted cytokine belonging to the IL-1 family. It is synthesized as a 152 amino acid mature protein that lacks an identifiable signal sequence. It binds to soluble IL-1 RI. Human IL-38/IL-1F10 shares 82% aa sequence identity with mouse  IL-38/IL-1F10. Human  IL-38/IL-1F10 also shares 39% and 27% aa sequence identity with IL-1ra/IL-1F3 and IL-1 beta /IL-1F2, respectively.

Long Name
Interleukin 1 Family Member 10
Entrez Gene IDs
84639 (Human); 215274 (Mouse); 102125744 (Cynomolgus Monkey)
Alternate Names
FIL1- theta; FKSG75; IL1F10; IL-1HY2; IL38; IL-38; interleukin 1 family, member 10 (theta); UNQ6119/PRO20041

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Citation for Human IL-38/IL-1F10 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Interleukin-1 family cytokines and their regulatory proteins in normal pregnancy and pre-eclampsia.
    Authors: Southcombe J, Redman C, Sargent I, Granne I
    Clin Exp Immunol, 2015-06-29;181(3):480-90.
    Species: Human
    Sample Types: Tissue Homogenates
    Applications: Western Blot

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