Human INSRR Antibody

Catalog #: MAB3055 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
MAB3055
MAB3055-SP

All INSRR Antibodies

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human INSRR Antibody Summary

Species Reactivity

Human

Specificity

Detects human INSRR in direct ELISAs and Western blots.

Source

Monoclonal Mouse IgG_2B Clone # 326929

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

Mouse myeloma cell line NS0-derived recombinant human INSRR
Leu24-Leu923
Accession # P14616

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration

Sample

Western Blot

1 µg/mL

Recombinant Human INSRR under non-reducing conditions only

Flow Cytometry

2.5 µg/10⁶ cells

Human peripheral blood mononuclear cells

CyTOF-ready

Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: INSRR

INSRR is a 175 kDa orphan receptor belonging to the insulin receptor subfamily of the receptor tyrosine kinase family. It is expressed in neuroblastoma and many adult tissues, including kidney, heart, pancreas, liver and skeletal muscle. INSRR is synthesized as a single chain type I transmembrane glycoprotein precursor and undergoes proteolytic processing to generate the mature disulfide linked alpha 2/ beta 2 tetrameric receptor. The alpha subunit is localized extracellularly while the transmembrane beta subunit contains an extracellular domain, a transmembrane segment and a cytoplasmic kinase domain. The extracellular domain of human INSRR shares approximately 90% amino acid sequence identity with mouse INSRR.

Long Name

Insulin Receptor-related Receptor

Entrez Gene IDs

3645 (Human); 23920 (Mouse)

Alternate Names

EC 2.7.10; EC 2.7.10.1; INSRR; insulin receptor-related protein; insulin receptor-related receptor; IRR; IRRIR-related receptor