Does this Biosimilar antibody have the same sequence as the therapeutic antibody?

Name: Human Integrin alpha L/CD11a (Research Grade Efalizumab Biosimilar) Antibody
Brand: R&D Systems
SKU: MAB10350
Price: 389 USD

The Biosimilar antibody has the same variable region and constant region sequence as the therapeutic antibody, except for Catalog numbers MAB9677, MAB9575, MAB9577, MAB9589, and their conjugates. These four antibodies have the same variable region as the Biosimilar, but not the same constant region.

Human Integrin alpha L/CD11a (Research Grade Efalizumab Biosimilar) Antibody

Catalog #: MAB10350 Datasheet / COA / SDS

Recombinant Monoclonal Antibody For Research Use Only

Catalog #	Availability	Size / Price	Qty
MAB10350-100
MAB10350-SP

Detection of Integrin aL/CD11a in human PBMC monocytes by Flow Cytometry.

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Human Integrin alpha L/CD11a (Research Grade Efalizumab Biosimilar) Antibody Summary

Species Reactivity

Human

Specificity

Detects Human Integrin alpha L/CD11a in direct ELISAs.

Source

Recombinant Monoclonal Human IgG₁ Clone # Hu103-2

Purification

Protein A or G purified from cell culture supernatant

Immunogen

Human Integrin alpha L/CD11a

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Endotoxin Level

<0.10 EU per 1 μg of the antibody by the LAL method.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Flow Cytometry

0.25 µg/10⁶ cells

See below

CyTOF-ready

Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry

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Detection of Integrin aL/CD11a in human PBMC monocytes by Flow Cytometry. Human PBMC monocytes were stained with Human Anti-Human Integrin aL/CD11a (Research Grade Efalizumab Biosimilar) Monoclonal Antibody (Catalog # MAB10350, filled histogram) or irrelevant antibody (open histogram) followed by APC-conjugated Anti-Human IgG Secondary Antibody (Catalog # F0135). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Integrin alpha L/CD11a

Efalizumab is a biosimilar directed against human Integrin alpha L/CD11a.

Entrez Gene IDs

3683 (Human); 16408 (Mouse); 308995 (Rat)

Alternate Names

CD11 antigen-like family member A; CD11a antigen; CD11a; CD11Aantigen CD11A (p180), lymphocyte function-associated antigen 1, alphapolypeptide; Integrin alpha L; integrin alpha-L; integrin gene promoter; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen1; alpha polypeptide); ITGAL; Leukocyte adhesion glycoprotein LFA-1 alpha chain; Leukocyte function-associated molecule 1 alpha chain; LFA-1 alpha; LFA-1; LFA1A; LFA-1A; Ly-15; Ly-21; lymphocyte function-associated antigen 1

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

FAQs

Does this Biosimilar antibody have the same sequence as the therapeutic antibody?
- The Biosimilar antibody has the same variable region and constant region sequence as the therapeutic antibody, except for Catalog numbers MAB9677, MAB9575, MAB9577, MAB9589, and their conjugates. These four antibodies have the same variable region as the Biosimilar, but not the same constant region.

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