Human Integrin alpha V/CD51 Antibody Summary
Phe31-Val992
Accession # NP_002201
*Small pack size (-SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Integrin alpha V/CD51 in Rat Mesenchymal Stem Cells. Integrin aV/CD51 was detected in immersion fixed rat mesenchymal stem cells using Mouse Anti-Human Integrin aV/ CD51 Monoclonal Antibody (Catalog # MAB12191) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; NL007) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.
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Detection of Integrin alpha V/CD51 in Huh‑7 human hepatoma cell line by Flow Cytometry Huh‑7 human hepatoma cell line were stained with Mouse Anti-Human Integrin alpha V/CD51 Monoclonal Antibody (Catalog # MAB12191, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram) followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0101B). View our protocol for Staining Membrane-associated Proteins.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Integrin alpha V/CD51
Integrin alpha V (CD51; also vitronectin receptor subunit alpha) is a 140‑150 kDa member of the integrin alpha -chain family of adhesion molecules. It forms disulfide-linked integral membrane heterodimers with at least five beta -chains, including beta 1, 3, 5, 6 and 8. Human alpha V is a 1018 aa type I transmembrane glycoprotein that contains a 962 aa extracellular domain (ECD) and a short 32 aa cytoplasmic tail. The ECD contains seven FG (PheAlaGly)-GAP (GlyAlaPro) repeats that form a beta -propellor domain (aa 46‑483). Furin cleavage of the alpha V ECD occurs after Gly889, generating a disulfide-linked heteromeric subunit alpha V chain. alpha V-containing integrins bind multiple ECM molecules, including vitronectin, osteopontin, MMP-2 and TSP. The ECD of human alpha V shares 92% and 90% aa sequence identity with mouse and rat alpha V ECD, respectively.
Product Datasheets
Citations for Human Integrin alpha V/CD51 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 3
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Translocating a High-Affinity Designer TIMP-1 to the Cell Membrane for Total Renal Carcinoma Inhibition: Putting the Prion Protein to Good Use
Authors: Bingjie Jiang, Yuewei Xu, Yihe Zhang, Meng Huee Lee
Molecular and Cellular Biology
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A Kaposi's Sarcoma-Associated Herpesvirus Infection Mechanism Is Independent of Integrins alpha 3 beta 1, alpha V beta 3, and alpha V beta 5
Authors: Allison Alwan TerBush, Florianne Hafkamp, Hee Jun Lee, Laurent Coscoy
Journal of Virology
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The deubiquitinase USP10 regulates integrin beta1 and beta5 and fibrotic wound healing
Authors: Stephanie R. Gillespie, Liana J. Tedesco, Lingyan Wang, Audrey M. Bernstein
Journal of Cell Science
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