Human ISLR-2 Antibody

Catalog #: AF4526
2 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
AF4526
AF4526-SP

All ISLR-2 Antibodies

Product Details

Citations (2)

Supplemental Products

Reviews

Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human ISLR-2 Antibody Summary

Species Reactivity

Human

Specificity

Detects human ISLR-2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 25% cross-reactivity with recombinant human ISLR-2 is observed.

Source

Polyclonal Sheep IgG

Purification

Antigen Affinity-purified

Immunogen

Mouse myeloma cell line NS0-derived recombinant human ISLR-2
Cys20-Leu590
Accession # Q6UXK2

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Western Blot

0.1 µg/mL

Recombinant Human ISLR‑2

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: ISLR-2

ISLR-2 (Ig-superfamily containing LRR protein 2; also KIAA1465) is a 100‑110 kDa member of the LRR family of proteins. It is expressed on developing motor, sensory and interneurons. Mature human ISLR-2 is 727 amino acids (aa) in length. It is a type I transmembrane glycoprotein that contains a 571 aa extracellular domain (ECD) and a 135 aa cytoplasmic region. The ECD shows multiple LRRs (aa 50‑227) and one Ig-like domain (aa 233‑371). One alternate splice form may exist that shows a deletion of aa 160‑570. Over aa 20‑590, human ISLR-2 is 89% aa identical to both canine and mouse ISLR-2.

Long Name

Immunoglobulin Superfamily Containing Leucine-rich Repeat 2

Entrez Gene IDs

57611 (Human); 320563 (Mouse)

Alternate Names

immunoglobulin superfamily containing leucine-rich repeat 2; ISLR2; ISLR-2; KIAA1465; leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein; LINX; UNQ1885/PRO4329

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

Citations for Human ISLR-2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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