Human ITFG1 APC-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: ITFG1

Integrin-alpha FG-GAP repeat-containing protein 1 (ITFG1), also known as T cell immunomodulatory protein (TIP), was initially identified using bioinformatics and high-throughput cell-based screening assays to isolate novel factors involved in T cell biology.  Ubiquitously expressed as a 96-100 kDa glycoprotein (it is absent on T cells, B cells, and monocytes), ITFG1 would appear to be a type I transmembrane protein that contains a 534 amino acids (aa) N-terminal ECD coupled to a 45 aa C-terminal transmembrane and cytoplasmic domain. Both soluble and transmembrane forms of the ITFG1 appear to exist. Human and mouse T cells treated with ITFG1 in vitro secreted the cytokines IFN-gamma, TNF-alpha and IL-10, while in vivo, ITFG1 was protective in a mouse acute graft-versus-host disease (GVHD) model. Based on invertebrate models, human ITFG1 likely serves as a cell adhesion molecule under certain circumstances. Over aa 1-566, human ITFG1 shares 89% and 88% aa sequence identity with mouse and rat ITFG1, respectively.

Product Datasheets