Human KIR2DL1/KIR2DS5 PE-conjugated Antibody Summary
Accession # P43626
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of KIR2DL1/KIR2DS5 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human KIR2DL1/KIR2DS5 PE-conjugated Monoclonal Antibody (Catalog # FAB1844P) and Mouse Anti-Human NCAM-1/CD56 APC-conjugated Monoclonal Antibody (Catalog # FAB2408A). Quadrant marker was set based on isotype control antibody staining (Catalog # IC002P). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: KIR2DL1/KIR2DS5
KIR2DL1 is one of several immunoglobulin-like receptors expressed on NK cells that bind MHC class I molecules and transmit inhibitory signals. KIR2DL1 is specific for HLA-C alleles with Asn77 and Lys80.
Product Datasheets
Citations for Human KIR2DL1/KIR2DS5 PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Hepatocellular carcinoma after direct-acting antivirals for hepatitis C is associated with KIR-HLA types predicting weak NK cell-mediated immunity
Authors: Ryan, JC;Haight, C;Niemi, EC;Grab, JD;Dodge, JL;Lanier, LL;Monto, A;
European journal of immunology
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma
Authors: F Cichocki, R Bjordahl, JP Goodridge, S Mahmood, S Gaidarova, R Abujarour, ZB Davis, A Merino, K Tuininga, H Wang, A Kumar, B Groff, A Witty, G Bonello, J Huffman, T Dailey, TT Lee, KJ Malmberg, B Walcheck, U Höpken, A Rehm, B Valamehr, JS Miller
Nature Communications, 2022-11-29;13(1):7341.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma
Authors: HC Tseng, W Xiong, S Badeti, Y Yang, M Ma, T Liu, CA Ramos, G Dotti, L Fritzky, JG Jiang, Q Yi, J Guarrera, WX Zong, C Liu, D Liu
Nat Commun, 2020-09-23;11(1):4810.
Species: Human
Sample Types: Whole Cells, Whole Tissue
Applications: Flow Cytometry, IHC -
Human NK cell receptor KIR2DS4 detects a conserved bacterial epitope presented by HLA-C
Authors: MJW Sim, S Rajagopala, DM Altmann, RJ Boyton, PD Sun, EO Long
Proc. Natl. Acad. Sci. U.S.A., 2019-05-28;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Contribution of NK cell education to both direct and anti-HIV-1 antibody-dependent NK cell functions
Authors: AB Kristensen, SJ Kent, MS Parsons
J. Virol., 2018-05-14;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Modulation of the natural killer cell KIR repertoire by cytomegalovirus infection.
Authors: Charoudeh H, Terszowski G, Czaja K, Gonzalez A, Schmitter K, Stern M
Eur J Immunol, 2012-12-12;43(2):480-7.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Natural killer lysis receptor (NKLR)/NKLR-ligand matching as a novel approach for enhancing anti-tumor activity of allogeneic NK cells.
Authors: Markel G, Seidman R, Besser MJ
PLoS ONE, 2009-05-19;4(5):e5597.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients.
Authors: Cai L, Zhang Z, Zhou L, Wang H, Fu J, Zhang S, Shi M, Zhang H, Yang Y, Wu H, Tien P, Wang FS
Clin. Immunol., 2008-09-27;129(3):428-37.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Blocking NK cell inhibitory self-recognition promotes antibody-dependent cellular cytotoxicity in a model of anti-lymphoma therapy.
Authors: Binyamin L, Alpaugh RK, Hughes TL, Lutz CT, Campbell KS, Weiner LM
J. Immunol., 2008-05-01;180(9):6392-401.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Natural killer cells in perinatally HIV-1-infected children exhibit less degranulation compared to HIV-1-exposed uninfected children and their expression of KIR2DL3, NKG2C, and NKp46 correlates with disease severity.
Authors: Ballan WM, Vu BA, Long BR, Loo CP, Michaelsson J, Barbour JD, Lanier LL, Wiznia AA, Abadi J, Fennelly GJ, Rosenberg MG, Nixon DF
J. Immunol., 2007-09-01;179(5):3362-70.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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