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Human KIR2DS1/CD158h Antibody

Catalog #: MAB8887
4 Citations Datasheet / COA / SDS
Recombinant Monoclonal Antibody
Catalog # Availability Size / Price Qty
MAB8887
MAB8887-SP
Detection of KIR2DS1/CD158h in Human PBMCs by Flow Cytometry.
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Citations (4)
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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human KIR2DS1/CD158h Antibody Summary

Species Reactivity
Human
Specificity
Detects human KIR2DS1/CD158h in flow cytometry. Clone 1127B recognizes KIR2DS1 and some alleles of KIR2DL1, both members of the killer cell immunoglobulin-like receptor (KIR) family. Because Clone 1127B displays partial cross-reactivity with KIR2DL1, co-staining with Mouse Anti-Human KIR2DL1 Clone 143211 (Catalog # FAB1844F) is recommended.
Source
Recombinant Monoclonal Rabbit IgG Clone # 1127B
Purification
Protein A or G purified from cell culture supernatant
Immunogen
HEK293 human embryonic kidney cell line transfected with human KIR2DS1/CD158h
Met1-His245
Accession # Q14954
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Flow Cytometry
0.25 µg/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of KIR2DS1/CD158h antibody in Human PBMCs antibody by Flow Cytometry. View Larger

Detection of KIR2DS1/CD158h in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) from different donors (A and B) were stained with Rabbit Anti-Human KIR2DS1/CD158h Monoclonal Antibody (Catalog # MAB8887) followed by Allophycocyanin-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # F0111) and Mouse Anti-Human KIR2DL1/KIR2DS5 Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB1844F). Cells were gated on CD56 with Mouse Anti-Human NCAM-1/CD56 PE-conjugated Monoclonal Antibody (Catalog # FAB2408P, not shown).

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: KIR2DS1/CD158h

The KIRs comprise a family of 14 polymorphic and homologous activating and inhibitory receptors expressed primarily on CD56dim NK cells. KIR2DS1 is an activating receptor with high homology to the inhibitory receptor KIR2DL1. Both KIR2DL1 and KIR2DS1 bind to HLA-C alleles containing the C2 epitope. KIR2DS1 and KIR2DL1 expression regulates NK cell licensing and activation in a number of immune contexts.

Long Name
Killer Cell Immunoglobulin-like Receptor, Two Domains, Short Cytoplasmic Tail, 1
Entrez Gene IDs
3806 (Human)
Alternate Names
killer cell immunoglobulin-like receptor 2DS1; CD158a; CD158h; EB6ActI; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1; KIR2DS1; p50.1

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Citations for Human KIR2DS1/CD158h Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

4 Citations: Showing 1 - 4
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  1. 3'-Sialyllactose protects against osteoarthritic development by facilitating cartilage homeostasis
    Authors: J Jeon, LJ Kang, KM Lee, C Cho, EK Song, W Kim, TJ Park, S Yang
    J. Cell. Mol. Med., 2017-08-07;0(0):.
  2. Hypoxia-inducible factor-1 alpha maintains mouse articular cartilage through suppression of NF- kappa B signaling
    Authors: Okada K, Mori D, Makii Y et Al.
    Sci Rep
  3. Safety, efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19+ B cell tumors: a phase 1/2 trial
    Authors: Marin, D;Li, Y;Basar, R;Rafei, H;Daher, M;Dou, J;Mohanty, V;Dede, M;Nieto, Y;Uprety, N;Acharya, S;Liu, E;Wilson, J;Banerjee, P;Macapinlac, HA;Ganesh, C;Thall, PF;Bassett, R;Ammari, M;Rao, S;Cao, K;Shanley, M;Kaplan, M;Hosing, C;Kebriaei, P;Nastoupil, LJ;Flowers, CR;Moseley, SM;Lin, P;Ang, S;Popat, UR;Qazilbash, MH;Champlin, RE;Chen, K;Shpall, EJ;Rezvani, K;
    Nature medicine
    Species: Human
    Sample Types: Whole Cells
    Applications: CyTof
  4. Structural and functional analysis of intra-articular interzone tissue in axolotl salamanders
    Authors: Rebekah S. Cosden-Decker, Melissa M. Bickett, Christian Lattermann, James N. MacLeod
    Osteoarthritis and Cartilage

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