Human LAIR2 Antibody Summary
Gln22-Pro152
Accession # Q6ISS4
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
View Larger
Detection of LAIR2 in Jurkat Human Cell Line by Flow Cytometry. Jurkat human acute T cell leukemia cell line was stained with Mouse Anti-Human LAIR2 Monoclonal Antibody (Catalog # MAB2665, filled histogram) or isotype control antibody (Catalog # MAB0041, open histogram), followed by Allophycocyanin-conjugated Anti-Mouse IgG F(ab')2Secondary Antibody (Catalog # F0101B). To facilitate intracellular staining, cells were fixed with paraformaldehyde and permeabilized with saponin.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: LAIR2
LAIR2 (leukocyte-associated Ig-like receptor-2; CD306) is a secreted, 131 amino acid (aa) protein that contains one Ig-like C2 type domain, making it a member of the Ig superfamily. When compared to LAIR1, its transmembrane counterpart, it shares 83% aa identity across the signal sequence and extracellular domains (1‑3). Although one is secreted and one is membrane-bound, the two LAIR proteins are thought to have arisen from a common gene ancestor and appear to share similar adhesion profiles. This suggests that LAIR2 may compete with LAIR1 for ligand binding (3, 4). A 114 aa alternate splice form of LAIR2 is truncated at the C terminus, but retains the entire Ig domain (1‑3). The expression profile of these splice forms, and the presence of orthologs in other species, have not been reported.
- Meyaard, L. (2003) J. Biol. Regul. Homeost. Agents 17:330.
- Meyaard, L. et al. (1999) J. Immunol. 162:5800.
- Meyaard, L. et al. (1997) Immunity 7:283.
- Xu, X.G. et al. (2005) Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 21:553.
Product Datasheets
Citations for Human LAIR2 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
3
Citations: Showing 1 - 3
Filter your results:
Filter by:
-
Single-cell transcriptome profiling of the stepwise progression of head and neck cancer
Authors: JH Choi, BS Lee, JY Jang, YS Lee, HJ Kim, J Roh, YS Shin, HG Woo, CH Kim
Nature Communications, 2023-02-24;14(1):1055.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
LAIR2-expressing extravillous trophoblasts associate with maternal spiral arterioles undergoing physiologic conversion.
Authors: Founds S, Fallert-Junecko B, Reinhart T, Parks W
Placenta, 2013-01-16;34(3):248-55.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Developing Potential Candidates of Preclinical Preeclampsia
Authors: Sandra Founds, Xuemei Zeng, David Lykins, James M. Roberts
International Journal of Molecular Sciences
FAQs
No product specific FAQs exist for this product, however you may
View all Antibody FAQsReviews for Human LAIR2 Antibody
Average Rating: 4.5 (Based on 2 Reviews)
Have you used Human LAIR2 Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
