Human LAP (TGF-beta 1) Antibody Summary
Leu30-Arg278 (Cys33Ser)
Accession # P01137
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: LAP (TGF-beta 1)
The TGF‑ beta family includes several related proteins (70‑80% sequence homology) from mammalian, avian, or Xenopus systems that are now designated TGF‑ beta 1, TGF‑ beta 2, TGF‑ beta 1.2, TGF‑ beta 3, TGF‑ beta 4, and TGF‑ beta 5. These proteins are secreted by cells in the form of an inactive complex, referred to as latent TGF-beta, that consists of TGF‑ beta associated non-covalently with a Latency-associated peptide (LAP). These two proteins are synthesized as a single pro-peptide that is cleaved in a post Golgi compartment prior to secretion. Different TGF‑ beta family members are naturally associated with their own distinct LAPs.
Product Datasheets
Citations for Human LAP (TGF-beta 1) Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Initial Myeloid Cell Status Is Associated with Clinical Outcomes of Renal Cell Carcinoma
Authors: Sabrina, S;Takeda, Y;Kato, T;Naito, S;Ito, H;Takai, Y;Ushijima, M;Narisawa, T;Kanno, H;Sakurai, T;Saitoh, S;Araki, A;Tsuchiya, N;Asao, H;
Biomedicines
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Neutrophil extracellular trap clearance by synovial macrophages in gout
Authors: JH Jeong, SJ Choi, SM Ahn, JS Oh, YG Kim, CK Lee, B Yoo, S Hong
Arthritis Research & Therapy, 2021-03-19;23(1):88.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Hierarchical involvement of myeloid derived suppressor cells and monocytes expressing latency-associated peptide in plasma cell dyscrasias
Authors: T Tadmor, I Levy, Z Vadasz
Turk J Haematol, 2018-03-28;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Association of peripheral NK cell counts with Helios+IFNy- Tregs in patients with good long-term renal allograft function
Authors: K Trojan, L Zhu, M Aly, R Weimer, N Bulut, C Morath, G Opelz, V Daniel
Clin. Exp. Immunol, 2017-03-13;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Monocyte-derived dendritic cells from Crohn's disease patients exhibit decreased ability to activate T helper type 17 responses in memory cells.
Authors: Nieminen J, Sipponen T, Farkkila M, Vaarala O
Clin Exp Immunol, 2014-07-01;177(1):190-202.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Induction of latency-associated peptide (transforming growth factor-beta(1)) expression on CD4+ T cells reduces Toll-like receptor 4 ligand-induced tumour necrosis factor-alpha production in a transforming growth factor-beta-dependent manner.
Authors: Boswell S, Sharif S, Alisa A, Pereira SP, Williams R, Behboudi S
Immunology, 2011-03-23;133(3):278-87.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Overexpression of TGF-ß 1 gene induces cell surface localized glucose-regulated protein 78-associated latency-associated peptide/TGF-ß.
Authors: Oida T, Weiner HL
J. Immunol., 2010-08-18;185(6):3529-35.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
HLA-DR+ leukocytes acquire CD1 antigens in embryonic and fetal human skin and contain functional antigen-presenting cells.
Authors: Schuster C, Vaculik C, Fiala C, Meindl S, Brandt O, Imhof M, Stingl G, Eppel W, Elbe-Burger A
J. Exp. Med., 2009-01-12;206(1):169-81.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-Fr -
Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFbeta-1.
Authors: Savage ND, De Boer T, Walburg KV, Joosten SA, van Meijgaarden K, Geluk A, Ottenhoff TH
J. Immunol., 2008-08-01;181(3):2220-6.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice.
Authors: Kitani A, Fuss I, Pedersen A, Nawata H
J. Immunol., 2004-01-15;172(2):834-42.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
FAQs
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How do you isolate human platelets for flow cytometry, using Human LAP (TGF-beta 1) Antibody, Catalog # MAB2463, and its conjugates?
We obtain the platelets from blood plasma by collection the top layer after spinning down whole blood. We proceed with a normal surface stain protocol; no special buffers are required.
Reviews for Human LAP (TGF-beta 1) Antibody
Average Rating: 5 (Based on 1 Review)
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