Home / Latent TGF-beta bp1 / Human Latent TGF-beta  bp1 Antibody

Human Latent TGF-beta  bp1 Antibody

Catalog #: MAB388
11 Citations 3 Reviews Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB388-SP
MAB388-500
MAB388-100
Product Details
Citations (11)
FAQs
Supplemental Products
Reviews (3)
Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Latent TGF-beta  bp1 Antibody Summary

Species Reactivity
Human
Specificity
Detects human LTBP-1 from the large latent TGF-beta 1 complex.
Source
Monoclonal Mouse IgG1 Clone # 35409
Purification
Protein A or G purified from ascites
Immunogen
Human platelet-derived large latent TGF-beta 1 complex
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Large latent TGF-beta complex from human platelets
under non-reducing conditions only
Immunoaffinity Purification
This antibody can be used to affinity purify the large latent TGF-beta complex (containing both the 230 and 195 kDa binding protein) and will also pull out “free” binding protein that is not associated with the small latent TGF-beta.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
Loading...
Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Latent TGF-beta bp1

TGF-beta  is synthesized as high molecular weight latent complexes. In platelets, the large latent TGF-beta 1 complex is composed of three components: mature TGF-beta 1 dimer; latency associated peptide; and a latent TGF-beta binding protein (LTBP) (1-3).The cDNAs for four binding proteins (LTBP-1, -2, -3 and -4) have now been cloned (4-5).

References
  1. Miyazono, K. et al. (1991) EMBO J. 10:1091.
  2. Moren, A. et al. (1994) J. Biol. Chem. 269:32469.
  3. Yin, W. et al. (1995) J. Biol. Chem. 270:10147.
  4. Kanzaki, T. et al. (1990) Cell 61:1051.
  5. Saharinen, J. et al. (1998) J. Biol. Chem. 273:18459.
Entrez Gene IDs
4052 (Human)
Alternate Names
Latent TGFbeta bp1; Latent TGF-beta bp1; latent transforming growth factor beta binding protein 1; latent-transforming growth factor beta-binding protein 1; LTBP1; LTBP-1; MGC163161; TGF-beta1-BP-1; Transforming growth factor beta-1-binding protein 1

Product Datasheets

You must select a language.

x
Product Datasheet
COA
SDS

Citations for Human Latent TGF-beta  bp1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

11 Citations: Showing 1 - 10
Filter your results:

Filter by:

  1. Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells
    Authors: AJ Alshawaf, S Viventi, W Qiu, G D'Abaco, B Nayagam, M Erlichster, G Chana, I Everall, J Ivanusic, E Skafidas, M Dottori
    Sci Rep, 2018-01-12;8(1):603.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  2. ATRA modulates mechanical activation of TGF-? by pancreatic stellate cells
    Sci Rep, 2016-07-04;6(0):27639.
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC
  3. Identification of the thiol isomerase-binding peptide, mastoparan, as a novel inhibitor of shear-induced transforming growth factor beta1 (TGF-beta1) activation.
    Authors: Brophy T, Coller B, Ahamed J
    J Biol Chem, 2013-03-05;288(15):10628-39.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  4. Kidney transplantation: analysis of the expression and T cell-mediated activation of latent TGF-beta.
    Authors: Willet J, Pichitsiri W, Jenkinson S, Brain J, Wood K, Alhasan A, Spielhofer J, Robertson H, Ali S, Kirby J
    J Leukoc Biol, 2012-11-27;93(4):471-8.
    Species: Human
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC-P
  5. Diverse functions of reactive cysteines facilitate unique biosynthetic processes of aggregate-prone interleukin-31.
    Authors: Shen M, Siu S, Byrd S, Edelmann KH, Patel N, Ketchem RR, Mehlin C, Arnett HA, Hasegawa H
    Exp. Cell Res., 2010-12-21;317(7):976-93.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  6. Assembly of fibrillin microfibrils governs extracellular deposition of latent TGF beta.
    Authors: Massam-Wu T, Chiu M, Choudhury R
    J. Cell. Sci., 2010-08-10;123(0):3006-18.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells
    Applications: ICC, Immunoprecipitation, Western Blot
  7. Matrix association of latent TGF-beta binding protein-2 (LTBP-2) is dependent on fibrillin-1.
    Authors: Vehvilainen P, Hyytiainen M, Keski-Oja J
    J. Cell. Physiol., 2009-12-01;221(3):586-93.
    Species: Human
    Sample Types: Cell Culture Supernates, Whole Cells
    Applications: ICC, Western Blot
  8. Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway.
    Authors: Gomez D, Al Haj Zen A, Borges LF, Philippe M, Gutierrez PS, Jondeau G, Michel JB, Vranckx R
    J. Pathol., 2009-05-01;218(1):131-42.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  9. Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-beta 1+CD4+ T regulatory cell infiltrates.
    Authors: Torrealba JR, Katayama M, Fechner JH, Jankowska-Gan E, Kusaka S, Schultz JM, Hu H, Hamawy MM, Jonker M, Wubben J, Doxiadis G, Bontrop R, Burlingham WJ, Knechtle SJ
    J. Immunol., 2004-05-01;172(9):5753-64.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  10. Sequestration of latent TGF-beta binding protein 1 into CADASIL-related Notch3-ECD deposits
    Authors: Jessica Kast, Patrizia Hanecker, Nathalie Beaufort, Armin Giese, Anne Joutel, Martin Dichgans et al.
    Acta Neuropathologica Communications
  11. Prestress in the extracellular matrix sensitizes latent TGF-beta 1 for activation
    Authors: Franco Klingberg, Melissa L. Chow, Anne Koehler, Stellar Boo, Lara Buscemi, Thomas M. Quinn et al.
    Journal of Cell Biology

FAQs

No product specific FAQs exist for this product, however you may

View all Antibody FAQs
Loading...

Reviews for Human Latent TGF-beta  bp1 Antibody

Average Rating: 3.7 (Based on 3 Reviews)

5 Star
0%
4 Star
66.67%
3 Star
33.33%
2 Star
0%
1 Star
0%

Have you used Human Latent TGF-beta  bp1 Antibody?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Human Latent TGF-beta  bp1 Antibody
By Anonymous on 01/14/2021
Application: Microarrays Sample Tested: EDTA Plasma Species: Human
Other Human Latent TGF-beta  bp1 Antibody MAB388
Human Latent TGF-beta  bp1 Antibody
By Anonymous on 02/07/2020
Application: MiAr Sample Tested: EDTA Plasma Species: Human

Antibody was printed on custom arrays and incubated with fluorescently labeled human EDTA plasma

Microarray Human Latent TGF-beta  bp1 Antibody MAB388
Human Latent TGF-beta  bp1 Antibody
By Anonymous on 11/14/2018
Application: Microarrays Sample Tested: EDTA Plasma Species: Human