Human Latent TGF-beta bp2/LTBP-2 Antibody

Catalog #: MAB3850 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
MAB3850
MAB3850-SP

All Latent TGF-beta bp2/LTBP-2 Antibodies

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Latent TGF-beta bp2/LTBP-2 Antibody Summary

Species Reactivity

Human

Specificity

Detects human Latent TGF‑ beta bp2/LTBP‑2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse LTMP-4 is observed.

Source

Monoclonal Mouse IgG_2B Clone # 327318

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Latent TGF‑ beta bp2/LTBP‑2
Gln36-Glu1821
Accession # NP_000419

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration

Sample

Western Blot

1 µg/mL

Recombinant Human Latent TGF-beta bp2 under non-reducing conditions only

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Latent TGF-beta bp2/LTBP-2

LTBP-2 is a 240 kDa member of the LTBP and fibrillin families. Unlike other LTBP, LTBP-2 is not a component of the large latent TGF-beta complex. LTBP-2 is a secreted calcium-binding extracellular matrix glycoprotein of elastic tissue 10 nm microfibrils, especially in the lung. The 1786 aa mature human LTBP2 contains 20 EGF‑like domains and four 8-cysteine repeats and shares 80% aa identity with mouse LTBP-2. An RGD sequence and a proline-rich sequence may mediate adhesion of melanoma cells, but for fibroblasts LTBP-2 may actually be an antiadhesion protein. In vivo, proteolysis by plasmin and elastase is likely and may cleave putative adhesion sites.

Entrez Gene IDs

4053 (Human)

Alternate Names

C14orf141; GLC3D; Latent TGFbeta bp2; Latent TGF-beta bp2; latent transforming growth factor beta binding protein 2; latent-transforming growth factor beta-binding protein 2; LTBP2; LTBP-2; LTBP3chromosome 14 open reading frame 141; MSTP031