Human Lipocalin-1 Antibody Summary
His19-Asp176
Accession # P31025
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Lipocalin-1
Lipocalin-1, also known as tear prealbumin or von Ebner’s gland protein (VEGP), is encoded by the LCN1 gene (1 - 3). It is a member of the Lipocalin superfamily that binds many different classes of lipophylic chemicals (4). Lipocalin-1 contains three sequence motifs similar to the cystatins, a superfamily of cysteine protease inhibitors (5). In fact, it has been suggested that Lipocalin-1 is a physiological inhibitor of cysteine proteases and plays a role in the control of inflammatory processes in oral and ocular tissues (5). rhLipocalin-1 corresponds to the mature and secreted protein. It is a weak inhibitor of cysteine proteases such as cathepsin V, which is similar to rhCystatin S (R&D Systems, Catalog # 1296-PI).
- Redl, B. et al. (1992) J. Biol. Chem. 267:20282.
- Blaker, M. et al. (1993) Biochim. Biophys. Acta 1172:131.
- Lassagne, H. and A.M. Gachon (1993) Exp. Eye Res. 56:605.
- Redl, B. et al. (2000) Biochim. Biophys. Acta 1482:241.
- van’t Hof, W. et al. (1997) J. Biol. Chem. 272:1837.
Product Datasheets
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