Human LRP-6 APC-conjugated Antibody Summary
Ala20-Pro1368
Accession # O75581
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Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
![Detection of LRP-6 antibody in MDA-MB-231 Human Cell Line antibody by Flow Cytometry. Detection of LRP-6 antibody in MDA-MB-231 Human Cell Line antibody by Flow Cytometry.](https://resources.rndsystems.com/images/datasheets/antibody/LRP6_FAB1505A_Flow_Cytometry_15090.jpg)
Detection of LRP‑6 in MDA‑MB‑231 Human Cell Line by Flow Cytometry. MDA-MB-231 human breast cancer cell line was stained with Mouse Anti-Human LRP-6 APC-conjugated Monoclonal Antibody (Catalog # FAB1505A, filled histogram) or isotype control antibody (Catalog # IC003A, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: LRP-6
LRP-6 (Low-density lipoprotein receptor-related protein 6) is a 200-210 kDa member of the LDLR family of proteins. It is widely expressed, and serves as a coreceptor for both Wnt and parathyroid hormone. In the Wnt system, LRP-6 associates with select Fzd multipass receptors; in the PTH system, LRP-6 complexes with PTH1R. Mature human LRP-6 is a 1594 amino acid (aa) type I transmembrane glycoprotein. It contains a 1351 aa extracellular region (aa 20-1370) plus a 220 aa cytoplasmic domain (aa 1394-1613). The cytoplasmic domain contains two palmitoylation sites, one ubiquitination residue, and multiple phosphorylation motifs.
Product Datasheets
Citations for Human LRP-6 APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 2
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Parkinson's disease-associated receptor GPR37 is an ER chaperone for LRP6
Authors: BS Berger, SP Acebron, J Herbst, S Koch, C Niehrs
EMBO Rep, 2017-03-24;0(0):.
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Whole Exome/Genome Sequencing Joint Analysis of a Family with Oligogenic Familial Hypercholesterolemia
Authors: Y Ghaleb, S Elbitar, A Philippi, P El Khoury, Y Azar, M Andrianiri, A Loste, Y Abou-Khali, G Nicolas, M Le Borgne, P Moulin, M Di-Filippo, S Charrière, M Farnier, C Yelnick, V Carreau, J Ferrières, JM Lecerf, A Derksen, G Bernard, MS Gauthier, B Coulombe, D Lütjohann, B Fin, A Boland, R Olaso, JF Deleuze, JP Rabès, C Boileau, M Abifadel, M Varret
Metabolites, 2022-03-18;12(3):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
FAQs
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Staining Reagents
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