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Human LXR alpha/NR1H3 Ligand Binding Domain Antibody

Catalog #: PP-PPZ0412-00
10 Citations Datasheet / COA / SDS
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PP-PPZ0412-00
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Citations (10)
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Summary Preparation and Storage Reconstitution Calculator Product Datasheets Related Research Areas

Human LXR alpha/NR1H3 Ligand Binding Domain Antibody Summary

Species Reactivity
Human
Source
Monoclonal Mouse IgG2a Clone # PPZ0412
Formulation
A liquid formulation in physiologic saline with 0.1% NaN3.

Applications

Recommended Concentration
Sample
Western Blot
Please refer to the PDF datasheet for specifications.
Immunohistochemistry
Please refer to the PDF datasheet for specifications.
Immunoprecipitation
Please refer to the PDF datasheet for specifications.
Gel Supershift Assay
Please refer to the PDF datasheet for specifications.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: LXR alpha/NR1H3

Long Name
Liver X Receptor alpha
Entrez Gene IDs
10062 (Human)
Alternate Names
alpha; Liver X receptor alpha; liver X receptor-alpha; LXR alpha; LXRA; NR1H3; Nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 3; oxysterols receptor LXR-alpha; RLD-1

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Citations for Human LXR alpha/NR1H3 Ligand Binding Domain Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

10 Citations: Showing 1 - 10
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  1. LXR-dependent enhancer activation regulates the temporal organization of the liver's response to refeeding leading to lipogenic gene overshoot
    Authors: Korenfeld, N;Gorbonos, T;Romero Florian, MC;Rotaro, D;Goldberg, D;Radushkevitz-Frishman, T;Charni-Natan, M;Bar-Shimon, M;Cummins, CL;Goldstein, I;
    PLoS biology
    Species: Mouse, Transgenic Mouse
    Sample Types: Tissue Homogenates
    Applications: Chromatin Immunoprecipitation (ChIP)
  2. Characterization and prognostic value of LXR splice variants in triple-negative breast cancer
    Authors: Priscilia Lianto, Samantha A. Hutchinson, J. Bernadette Moore, Thomas A. Hughes, James L. Thorne
    iScience
  3. Pioneer factor Foxa2 enables ligand-dependent activation of type II nuclear receptors FXR and LXR alpha
    Authors: Kain J, Wei X, Reddy Na Et Al.
    Molecular metabolism
  4. Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer
    Authors: Samantha A. Hutchinson, Alex Websdale, Giorgia Cioccoloni, Hanne Røberg-Larsen, Priscilia Lianto, Baek Kim et al.
    Oncogene
  5. 4 beta -Hydroxycholesterol is a prolipogenic factor that promotes SREBP1c expression and activity through the liver X receptor
    Authors: Ofer Moldavski, Peter-James H. Zushin, Charles A. Berdan, Robert J. Van Eijkeren, Xuntian Jiang, Mingxing Qian et al.
    Journal of Lipid Research
  6. LXR alpha Regulates ChREBP alpha Transactivity in a Target Gene-Specific Manner through an Agonist-Modulated LBD-LID Interaction
    Authors: Fan Q, Norgaard RC, Grytten I et al.
    Cells
  7. Inflammation Triggers Liver X Receptor-Dependent Lipogenesis
    Authors: Sophie R. Liebergall, Jerry Angdisen, Shun Hang Chan, YingJu Chang, Timothy F. Osborne, Alexander F. Koeppel et al.
    Molecular and Cellular Biology
  8. An Essential Role for Liver ER? in Coupling Hepatic Metabolism to the Reproductive Cycle
    Authors: S Della Torr, N Mitro, R Fontana, M Gomaraschi, E Favari, C Recordati, F Lolli, F Quagliarin, C Meda, C Ohlsson, M Crestani, NH Uhlenhaut, L Calabresi, A Maggi
    Cell Rep, 2016-03-31;15(2):360-71.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: ChIP
  9. Activation of liver X receptor sensitizes human dendritic cells to inflammatory stimuli.
    Authors: Torocsik D, Barath M, Benko S, Szeles L, Dezso B, Poliska S, Hegyi Z, Homolya L, Szatmari I, Lanyi A, Nagy L
    J. Immunol., 2010-04-21;184(10):5456-65.
    Species: Human
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC-P, Western Blot
  10. Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense.
    Authors: Smoak K, Madenspacher J, Jeyaseelan S, Williams B, Dixon D, Poch KR, Nick JA, Worthen GS, Fessler MB
    J. Immunol., 2008-03-01;180(5):3305-12.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P

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