Home / MIS/AMH / Human MIS/AMH Propeptide Antibody

Human MIS/AMH Propeptide Antibody

Catalog #: AF2748
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
AF2748
AF2748-SP
Product Details
Citations (3)
FAQs
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human MIS/AMH Propeptide Antibody Summary

Species Reactivity
Human
Specificity
Detects human MIS/AMH Propeptide in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with mature recombinant human MIS is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant human MIS/AMH Propeptide
Leu19-Gln450
Accession # P03971
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Human MIS/AMH (Catalog # 1737-MS)
Immunohistochemistry
5-15 µg/mL
Immersion fixed paraffin-embedded sections of human ovary subjected to Antigen Retrieval Reagent-Basic (Catalog # CTS013)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: MIS/AMH

MIS, also known as anti-Mullerian Hormone (AMH), belongs to the TGF-beta superfamily. It is synthesized as a 140 kDa homodimeric glycoprotein that undergoes proteolytic cleavage into the bioactive homodimeric 26 kDa carboxy-terminus and the 110 kDa dimeric amino-terminus. After cleavage, the amino-terminal propeptide remains non-covalently associated with the bioactive carboxy-terminal active protein. The amino acid sequence of human and mouse MIS propeptides are 67% identical.

Long Name
Mullerian-inhibiting Substance/Anti-Mullerian Hormone
Entrez Gene IDs
268 (Human); 11705 (Mouse)
Alternate Names
AMH; MIF; MIS; Muellerian hormone; muellerian-inhibiting factor; muellerian-inhibiting substance; Mullerian hormone; Mullerian inhibiting factor; Mullerian inhibiting substance

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Citations for Human MIS/AMH Propeptide Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

3 Citations: Showing 1 - 3
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  1. The proportion of cleaved anti-M�llerian hormone is higher in serum but not follicular fluid of obese women independently of polycystic ovary syndrome
    Authors: M Peigné, P Pigny, MW Pankhurst, E Drumez, A Loyens, D Dewailly, S Catteau-Jo, P Giacobini
    Reprod Biomed Online, 2020-07-25;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  2. Up-Regulation of SOX9 in Sertoli Cells from Testiculopathic Patients Accounts for Increasing Anti-Mullerian Hormone Expression via Impaired Androgen Receptor Signaling
    Authors: Kuo-Chung Lan, Yen-Ta Chen, Chawnshang Chang, Yung-Chiao Chang, Hsin-Jung Lin, Ko-En Huang et al.
    PLoS ONE
  3. Evidence for a Mullerian-inhibiting substance autocrine/paracrine system in adult human endometrium.
    Authors: Wang J, Dicken C, Lustbader JW, Tortoriello DV
    Fertil. Steril., 2008-03-07;91(4):1195-203.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC

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