Human MMP-12 Catalytic Domain Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of MMP-12 Catalytic Domain by Immunohistochemistry MMP-12 expression level becomes increasingly elevated as prostate cancer progresses: A, The MMP-12 protein expression (left) and quantification (right) in patients with pathological stages of benign prostatic hyperplasia (BPH), androgen-dependent prostate cancer (ADPC), and castration-resistant prostate cancer (CRPC) was determined by immunohistochemistry (scale bar 100 μm). B, The concentration of MMP-12 protein in the serum of the different groups of patients was determined by ELISA. Data are reported as means±SD. **P<0.01, ***P<0.001, and ****P<0.0001 unpaired t-test. ns: not significant. Image collected and cropped by CiteAb from the following open publication (http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2024000100621&tlng=en), licensed under a CC-BY license. Not internally tested by R&D Systems.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: MMP-12
MMP-12, also known as macrophage elastase, is a zinc and calcium dependent endopeptidase expressed constitutively in macrophages and can be induced in monocytes. MMP-12 can degrade a broad spectrum of substrates, including type IV collagen, fibronectin, laminin, vitronectin, proteoglycans, chondroitin sulfate, myelin basic protein, alpha 1-antitrypsin, and plasminogen. It can also activate MMP-2 and MMP-3. The MMP-12 precursor consists of a pro domain, a catalytic domain containing the zinc-binding site, and a C-terminal hemopexin-like domain.
Product Datasheets
Citations for Human MMP-12 Catalytic Domain Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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MMP-14 Exhibits Greater Expression, Content and Activity Compared to MMP-15 in Human Renal Carcinoma
Authors: M?ynarczyk, G;Tokarzewicz, A;Gudowska-Sawczuk, M;Mroczko, B;Novák, V;Novák, A;Mitura, P;Romanowicz, L;
International journal of molecular sciences
Species: Human
Sample Types: Tissue Lysates
Applications: Western Blot -
Comprehensive Gene Analysis of IgG4-Related Ophthalmic Disease Using RNA Sequencing
Authors: M Asakage, Y Usui, N Nezu, H Shimizu, K Tsubota, K Umazume, N Yamakawa, T Umezu, H Suwanai, M Kuroda, H Goto
J Clin Med, 2020-10-27;9(11):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Redundancy of IL-1 Isoform Signaling and Its Implications for Arterial Remodeling.
Authors: Marina Beltrami-M, Amélie Vromman, Galina K Sukhova, Eduardo J Folco, Peter Libby
PLoS ONE, 2016-03-31;0(0):1932-6203.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Western Blot -
Developing Potential Candidates of Preclinical Preeclampsia
Authors: Sandra Founds, Xuemei Zeng, David Lykins, James M. Roberts
International Journal of Molecular Sciences
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Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase 12 via IGF-2 and VEGF signaling pathways.
Authors: Wang P, Chen S, Hung W, Paul C, Zhu F, Guan P, Huso D, Kontrogianni-Konstantopou A, Konstantopoulos K
Oncogene, 2014-12-01;34(35):4558-69.
Species: Human
Sample Types: Whole Cells, Whole Tissue
Applications: IHC, Neutralization -
Matrix metalloproteinase activity in pediatric acute lung injury.
Authors: Kong MY, Gaggar A, Li Y
Int J Med Sci, 2008-12-16;6(1):9-17.
Species: Human
Sample Types: Tissue Secretion
Applications: Western Blot -
Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx.
Authors: Dean RA, Cox JH, Bellac CL, Doucet A, Starr AE, Overall CM
Blood, 2008-07-25;112(8):3455-64.
Species: Human
Sample Types: Recombinant Protein
Applications: Western Blot -
Langerhans cell histiocytosis reveals a new IL-17A-dependent pathway of dendritic cell fusion.
Authors: Coury F, Annels N, Rivollier A, Olsson S, Santoro A, Speziani C, Azocar O, Flacher M, Djebali S, Tebib J, Brytting M, Egeler RM, Rabourdin-Combe C, Henter JI, Arico M, Delprat C
Nat. Med., 2007-12-23;14(1):81-7.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Gene expression analysis of dendritic/Langerhans cells and Langerhans cell histiocytosis.
Authors: Rust R, Kluiver J, Visser L, Harms G, Blokzijl T, Kamps W, Poppema S, Van Den Berg A
J. Pathol., 2006-08-01;209(4):474-83.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Human bronchial epithelial cells express and secrete MMP-12.
Authors: Lavigne MC, Thakker P, Gunn J, Miyashiro JS, Wasserman AM, Wei SQ, Pelker JW
Biochem. Biophys. Res. Commun., 2004-11-12;324(2):534-46.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Immunoprecipitation
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