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Human/Mouse Active Caspase-3 Antibody

Catalog #: AF835
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AF835
AF835-SP
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Caspase‑3 in Jurkat Human Cell Line.
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Human/Mouse Active Caspase-3 Antibody Summary

Species Reactivity
Human, Mouse
Specificity
Distinguishes apoptotic cells from non-apoptotic cells in immunohistochemistry. Detects the p17 subunit of Caspase-3, but does not detect the precursor form in Western blot. We recommend R&D Systems Affinity Purified Anti-Caspase-3 (Catalog # AF-605-NA) or Monoclonal Anti-Cleaved-Caspase-3 (Catalog # MAB835) for Western blot applications.
Source
Polyclonal Rabbit IgG
Purification
Antigen Affinity-purified
Immunogen
KLH-coupled human Caspase-3 synthetic peptide
CRGTELDCGIETD
Accession # P42574
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Immunohistochemistry
1-15 µg/mL
See below
Immunocytochemistry
5-15 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunocytochemistry Caspase‑3 antibody in Jurkat Human Cell Line by Immunocytochemistry (ICC). View Larger

Caspase‑3 in Jurkat Human Cell Line. Caspase‑3 was detected in immersion fixed anti-FAS treated Jurkat human acute T cell leukemia cell line using 0.3 µg/mL Human/Mouse Active Caspase‑3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF835) for 3 hours at room temperature. Cells were stained (red) and counterstained (green). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Immunocytochemistry Caspase-3 antibody in Jurkat Human Cell Line by Immunocytochemistry (ICC). View Larger

Caspase‑3 in Jurkat Human Cell Line. Caspase-3 was detected in immersion fixed Jurkat human acute T cell leukemia cell line stimulated with staurosporin using Human/Mouse Active Caspase-3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF835) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Rabbit IgG Secondary Antibody (yellow; Catalog # NL004) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Immunohistochemistry Caspase-3 antibody in Human Colon Cancer Tissue by Immunohistochemistry (IHC-P). View Larger

Caspase‑3 in Human Colon Cancer Tissue. Caspase-3 was detected in immersion fixed paraffin-embedded sections of human colon cancer tissue using Rabbit Anti-Human/Mouse Active Caspase-3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF835) at 1 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Rabbit IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC003). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Immunohistochemistry Detection of Guinea Pig Caspase-3 by Immunohistochemistry View Larger

Detection of Guinea Pig Caspase-3 by Immunohistochemistry Representative sections of the medial side of right tibial epiphysis stained with/without caspase-3. Sections stained with caspase-3 antibody at four different time points (DH: A, C, E and G; BS2: B, D, F and H); a higher magnification (I); the growth plate (J) and fibrocartilage of anterior cruciate ligament (K) show caspase-3 positive cells (red cytoplasmic staining; arrow). A negative control section is shown in (L). Image collected and cropped by CiteAb from the following publication (https://www.mdpi.com/1422-0067/14/9/17729), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Guinea Pig Caspase-3 by Immunohistochemistry View Larger

Detection of Guinea Pig Caspase-3 by Immunohistochemistry Representative sections of the medial side of right tibial epiphysis stained with/without caspase-3. Sections stained with caspase-3 antibody at four different time points (DH: A, C, E and G; BS2: B, D, F and H); a higher magnification (I); the growth plate (J) and fibrocartilage of anterior cruciate ligament (K) show caspase-3 positive cells (red cytoplasmic staining; arrow). A negative control section is shown in (L). Image collected and cropped by CiteAb from the following publication (https://www.mdpi.com/1422-0067/14/9/17729), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Mouse Caspase-3 by Immunohistochemistry View Larger

Detection of Mouse Caspase-3 by Immunohistochemistry Immunohistochemical staining for caspase 3 on surgically transected tumours. A) Epo-treated tumour 24 hours after surgery. B) Placebo-treated tumour 24 hours after surgery. C) Placebo-treated tumour 48 hours after surgery Image collected and cropped by CiteAb from the following publication (https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-14-648), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Mouse Caspase-3 by Immunohistochemistry View Larger

Detection of Mouse Caspase-3 by Immunohistochemistry LPS challenge induces cell shedding from small intestinal villi. C57 BL/6 mice were administered either (a) PBS (control) or (b) LPS by IP injection and proximal small intestines removed after 1.5 h. Processed tissue was sectioned and stained by immunohistochemistry for CC3 (i.e. brown cells indicate shedding event), also highlighted by arrows. A representative picture for each group is shown (12 mice per group, two independent experiments). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/28123052), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Guinea Pig Caspase-3 by Immunohistochemistry View Larger

Detection of Guinea Pig Caspase-3 by Immunohistochemistry Representative sections of the medial side of right tibial epiphysis stained with/without caspase-3. Sections stained with caspase-3 antibody at four different time points (DH: A, C, E and G; BS2: B, D, F and H); a higher magnification (I); the growth plate (J) and fibrocartilage of anterior cruciate ligament (K) show caspase-3 positive cells (red cytoplasmic staining; arrow). A negative control section is shown in (L). Image collected and cropped by CiteAb from the following publication (https://www.mdpi.com/1422-0067/14/9/17729), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse Caspase-3 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse Caspase-3 by Immunocytochemistry/Immunofluorescence The cytoprotective effect of B. breve is MyD88 dependent. (a,b) IEC MyD88+/+ mice and (c,d) IEC MyD88−/− mice were gavaged with PBS (control) or B. breve UCC2003 and challenged with LPS. Paraffin-embedded intestinal sections were stained with anti-CC3 and quantified using the WinCrypts and Score programs. (e) Columns shown TLR2 expression via RT-PCR. Data are mean ± s.d., n = 12 (two independent experiments) analysed with Mann–Whitney U-test. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/28123052), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Guinea Pig Caspase-3 by Immunohistochemistry View Larger

Detection of Guinea Pig Caspase-3 by Immunohistochemistry Representative sections of the medial side of right tibial epiphysis stained with/without caspase-3. Sections stained with caspase-3 antibody at four different time points (DH: A, C, E and G; BS2: B, D, F and H); a higher magnification (I); the growth plate (J) and fibrocartilage of anterior cruciate ligament (K) show caspase-3 positive cells (red cytoplasmic staining; arrow). A negative control section is shown in (L). Image collected and cropped by CiteAb from the following publication (https://www.mdpi.com/1422-0067/14/9/17729), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Guinea Pig Caspase-3 by Immunohistochemistry View Larger

Detection of Guinea Pig Caspase-3 by Immunohistochemistry Representative sections of the medial side of right tibial epiphysis stained with/without caspase-3. Sections stained with caspase-3 antibody at four different time points (DH: A, C, E and G; BS2: B, D, F and H); a higher magnification (I); the growth plate (J) and fibrocartilage of anterior cruciate ligament (K) show caspase-3 positive cells (red cytoplasmic staining; arrow). A negative control section is shown in (L). Image collected and cropped by CiteAb from the following publication (https://www.mdpi.com/1422-0067/14/9/17729), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Guinea Pig Caspase-3 by Immunohistochemistry View Larger

Detection of Guinea Pig Caspase-3 by Immunohistochemistry Representative sections of the medial side of right tibial epiphysis stained with/without caspase-3. Sections stained with caspase-3 antibody at four different time points (DH: A, C, E and G; BS2: B, D, F and H); a higher magnification (I); the growth plate (J) and fibrocartilage of anterior cruciate ligament (K) show caspase-3 positive cells (red cytoplasmic staining; arrow). A negative control section is shown in (L). Image collected and cropped by CiteAb from the following publication (https://www.mdpi.com/1422-0067/14/9/17729), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse Caspase-3 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse Caspase-3 by Immunocytochemistry/Immunofluorescence Bifidobacterium breve UCC2003 protects against LPS-induced cell shedding. C57 BL/6 mice received three daily oral gavage doses of (a) PBS or (b) approximately 1 × 109B. breve UCC2003 followed by IP challenge with LPS 24 h later. Representative images are shown. Formalin-fixed, paraffin-embedded intestinal sections were sectioned and stained with anti-CC3 and (c) quantified using the WinCrypts and Score programs, 20 well-orientated hemi-villi were counted per mouse. Data are mean ± s.d., n = 12 (two independent experiments) analysed with a Mann–Whitney U-test. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/28123052), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Guinea Pig Caspase-3 by Immunohistochemistry View Larger

Detection of Guinea Pig Caspase-3 by Immunohistochemistry Representative sections of the medial side of right tibial epiphysis stained with/without caspase-3. Sections stained with caspase-3 antibody at four different time points (DH: A, C, E and G; BS2: B, D, F and H); a higher magnification (I); the growth plate (J) and fibrocartilage of anterior cruciate ligament (K) show caspase-3 positive cells (red cytoplasmic staining; arrow). A negative control section is shown in (L). Image collected and cropped by CiteAb from the following publication (https://www.mdpi.com/1422-0067/14/9/17729), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse Caspase-3 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse Caspase-3 by Immunocytochemistry/Immunofluorescence Genetic deletion of Bax prevents mutant LRRK2 induced neuronal death. Primary embryonic cortical neurons are derived from WT mice or mice lacking the pro-apoptotic protein Bax, and transiently transfected with GFP-tagged WT or mutant LRRK2 (R1441C, G2019S). (a) A representative image showing typical morphological features of apoptotic neurons expressing mutant LRRK2; that are positive for active caspase-3 (casp3) and display condensed and fragmented nuclei. (b) Quantification of apoptotic neuronal death (apoptotic nuclear profiles, “apo”; and active caspase-3 positive neurons, “casp3”) from cultures depicted in (a); **p < 0.01 in comparison to WT transfected neurons. (c) Primary neurons were prepared from WT mice or mice deficient in Bax, and treated with the topoisomerase I inhibitor camptothecin (“cam”, 5 μM, 18 hr), or doxorubicin (“doxo”, 10 ng/ml, 36 hr). Cells were fixed and processed for apoptotic nuclear counts. (d) Primary cortical neurons were prepared from WT mice or mice deficient in Bax, and transiently transfected with WT, R1441C, or G2019S LRRK2. As before, the cultures were fixed and the percentage of LRRK2-positive neurons that displayed apoptotic nuclear features was determined. The absence of Bax significantly protected neurons from death induced by mutant LRRK2. ***p < 0.001 compared to WT neurons expressing R1441C- or G2019S-LRRK2. Each data point represents the mean +/− SEM from 3–4 independent transfections from a representative culture. Cultures were repeated at least 3 times with similar differences. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/29472595), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse Caspase-3 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse Caspase-3 by Immunocytochemistry/Immunofluorescence Hepatocyte ARNT deletion alters fibrotic and apoptotic gene expression in the TAA model of fibrosis.Results for FC are shown in black columns and LARNT in white columns. Results are expressed relative to FC level. (A) Messenger RNA expression of ARNT and collagen isotypes. (B) Expression of genes regulating fibrosis in FC and LARNT mice. (C) F4/80 and inflammatory cytokine expression in FC and LARNT mice. (D) Apoptotic gene expression in FC and LARNT mice. (E) Representative histology of FC liver stained with anti-Caspase 3 at 100X magnification. (F) Representative histology of LARNT liver stained with anti-Caspase 3 at 100X magnification. (G) Average Caspase 3 positive cell counts per field of view at 100 X magnification. Mean±SEM, * = p<0.05 ** = p<0.01, *** = p<0.001. N = 5-6/group. Image collected and cropped by CiteAb from the following publication (https://dx.plos.org/10.1371/journal.pone.0121650), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse Caspase-3 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse Caspase-3 by Immunocytochemistry/Immunofluorescence p140Cap expression is causative in limiting tumour growth in NeuT mice.(a) Expression cassette used for the generation of MMTV-p140Cap transgenic mice. The Myc epitope is inserted at the carboxyterminal region of the protein. (b) Extracts of tumours derived from NeuT mice (a,b) or p140-NeuT mice (c,d) were run on 6% SDS–PAGE and stained with antibodies to p140Cap, ERBB2 and tubulin for loading control. (c) Percentage of tumour free mice in NeuT (red line) and p140-NeuT (blue-dashed line) transgenic animals in both FVB (left) or BALB/c background (right). Twelve mice were analysed for each group. Fisher's exact test, Two sided, P=0,0022; P=0,0056. Error bar: s.e.m. (d) Total tumour burden in NeuT (red) and p140-NeuT (blue) mice in both the FVB (left) or BALB/c backgrounds (right) was measured. Ten mice were analysed in each group. Unpaired t test: (*P<0.05; ***P<0.001). Error bar: s.e.m. (e) Paraffin-embedded sections from three NeuT and three p140-NeuT tumours taken from mice at 33 weeks of age were analysed for hematoxylin–eosin (H&E) (a–d) and for immunohistochemistry with antibodies to NeuT (e–h), PCNA (i–l) and activated Caspase3 (m–p). Representative images are shown. Scale bar, 50 μm (first and third columns); 20μm (second and fourth columns). Histograms on the right show the percentage of PCNA+ (upper panel) and Activated Caspase3+ (lower panel) cells. Statistical significative differences were evaluated using unpaired t-tests (***P<0.001). Image collected and cropped by CiteAb from the following publication (https://www.nature.com/articles/ncomms14797), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse Caspase-3 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse Caspase-3 by Immunocytochemistry/Immunofluorescence Microglia-derived TNF-alpha alleviates aberrant neurogenesis.(a) qRT-PCR analyses of Tnf-alpha levels in the DG of WT and TLR9 KO mice at the indicated time points after seizure. Experimental controls were KA-untreated WT and TLR9 KO mice, respectively (n=3 animals). *P<0.05 by analysis of variance (ANOVA) with Tukey post-hoc tests. (b) Experimental scheme for assessing aNS/PC proliferation in microglia culture-derived CM pretreated with TNF-alpha -neutralizing antibody or IgG control. (c) Representative images of EdU (red), active caspase3 (green) and Hoechst (blue) staining in aNS/PCs cultured with the indicated CM from microglia (n=4 experiments). Scale bar, 50 μm. (d) Quantification of EdU+ or active caspase3+ cells in c (n=4 experiments). (e) Experimental timeline for assessing aNS/PC proliferation in thalidomide (Thal)-treated mice. (f) Representative images of BrdU+DCX+ newly generated immature neurons in the DG (n=4 animals). Scale bar, 50 μm. (g,h) Quantification of the number of BrdU+DCX+ cells in f, in the DG (g) and in the hilus (h) (n=4 animals). *P<0.05 and **P<0.01 by ANOVA with Tukey post-hoc tests. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/25751136), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Human Caspase-3 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Human Caspase-3 by Immunocytochemistry/Immunofluorescence Double immunofluorescent staining of FSGS kidneys to Ki-67, alpha -tubulin and DAPI or double immunofluorescent staining to caspase-3 and DAPI. A. FSGS kidneys: cysts with simple squamous epithelium (CS) filled with colloid content, interstitium (i) and collecting tubules (ct) contain Ki-67-positive cells (arrows)(square). B. alpha -tubulin visualizes short cilia (arrows) in the cysts and extremely long cilia in collecting tubules (arrows)(square). C. Nuclear DAPI stain. D. Merging of A + B + C shows relationships between proliferating cells (green) and cilia (red). Immunostaining to Ki-67, alpha -tubulin and DAPI; scale bar 10 μm. E. Distribution of Ki-67 positive cells (%) in CNF and FSGS nephrotic syndrome. Cysts of proximal tubules with simple squamous epithelium (CS) or simple cuboidal epithelium (CC), proximal tubules with apparently normal simple cuboidal/columnar epithelium (PTNC). Data are shown as mean ± SD. Significant differences (Kruskal–Wallis) indicated by ***p < 0.0001. F. FSGS kidneys: caspase-3-positive apoptotic cells (arrows) in proximal tubules (PTNC) and interstitium (i). G. Nuclear DAPI stain. H. Merging of F + G shows green caspase-3- positive apoptotic nuclei and blue non-apoptotic nuclei. Immunostaining to caspase-3 and DAPI, scale bar 10 μm. Image collected and cropped by CiteAb from the following publication (https://bmcnephrol.biomedcentral.com/articles/10.1186/1471-2369-15-3), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Mouse Caspase-3 by Immunohistochemistry View Larger

Detection of Mouse Caspase-3 by Immunohistochemistry Epidermis-specific deletion of Rac1 increases UV-light-induced keratinocyte apoptosis in vivo. (a) H/E staining of UV-irradiated skin of Rac1 fl/fl and Rac1-EKO mice at 12 h after UV-irradiation. Black arrows indicate sunburn cells. (b) Graph shows the percentage number of sunburn cells at 12 h with (red bars) or without (blue bars) UV-irradiation in Rac1 fl/fl (n=4) and Rac1-EKO (n=5) mice. The percentage of sunburn cells within the epidermis after UV-irradiation in Rac1 fl/fl mice was 3.4%, whereas in Rac1-EKO mice it was 8.6% of total epidermal keratinocytes. Non-irradiated samples showed <1% sunburn cells in both the genotypes. (c) Immunostainings against cleaved caspase-3 (green) of UV-irradiated skin of Rac1 fl/fl and Rac1-EKO mice at 12 h after UV-irradiation. Nuclei are stained in blue. Scale bar=100 μm. (d) Western blot analysis of cleaved caspase-3 from epidermal lysates of untreated (no UV) and UV-light treated (UV) Rac1 fl/fl and Rac1-EKO mice. Non-irradiated controls showed no bands for cleaved capsase-3, whereas samples of irradiated epidermis showed cleaved caspase-3-specific bands at ~25 kDa and 23 kDa. Numbers on the left denote molecular weights in kDa. (e) Graph shows densitometry analysis of western blot in (d). Error bars show S.D. Asterisks show P-value<0.001 Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/28277539), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse Caspase-3 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse Caspase-3 by Immunocytochemistry/Immunofluorescence Hepatocyte ARNT deletion alters fibrotic and apoptotic gene expression in the TAA model of fibrosis.Results for FC are shown in black columns and LARNT in white columns. Results are expressed relative to FC level. (A) Messenger RNA expression of ARNT and collagen isotypes. (B) Expression of genes regulating fibrosis in FC and LARNT mice. (C) F4/80 and inflammatory cytokine expression in FC and LARNT mice. (D) Apoptotic gene expression in FC and LARNT mice. (E) Representative histology of FC liver stained with anti-Caspase 3 at 100X magnification. (F) Representative histology of LARNT liver stained with anti-Caspase 3 at 100X magnification. (G) Average Caspase 3 positive cell counts per field of view at 100 X magnification. Mean±SEM, * = p<0.05 ** = p<0.01, *** = p<0.001. N = 5-6/group. Image collected and cropped by CiteAb from the following publication (https://dx.plos.org/10.1371/journal.pone.0121650), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Mouse Caspase-3 by Immunohistochemistry View Larger

Detection of Mouse Caspase-3 by Immunohistochemistry Immunohistochemical staining for caspase 3 on surgically transected tumours. A) Epo-treated tumour 24 hours after surgery. B) Placebo-treated tumour 24 hours after surgery. C) Placebo-treated tumour 48 hours after surgery Image collected and cropped by CiteAb from the following publication (https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-14-648), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Guinea Pig Caspase-3 by Immunohistochemistry View Larger

Detection of Guinea Pig Caspase-3 by Immunohistochemistry Representative sections of the medial side of right tibial epiphysis stained with/without caspase-3. Sections stained with caspase-3 antibody at four different time points (DH: A, C, E and G; BS2: B, D, F and H); a higher magnification (I); the growth plate (J) and fibrocartilage of anterior cruciate ligament (K) show caspase-3 positive cells (red cytoplasmic staining; arrow). A negative control section is shown in (L). Image collected and cropped by CiteAb from the following publication (https://www.mdpi.com/1422-0067/14/9/17729), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Mouse Caspase-3 by Western Blot View Larger

Detection of Mouse Caspase-3 by Western Blot DNA damage has an important role in increased UV-light-induced keratinocyte apoptosis in Rac1-EKO epidermis in vivo. (a and c) H/E stainings and immunostainings against cleaved caspase-3 (green) of UV-irradiated skin of CPDPL/Rac1-EKO mice kept in the dark and under the photoreactivation lamp. Nuclei are stained in blue. Dashed line in c demarcates border between epidermis and dermis. Scale bar=100 μm. (e) Western blot analysis of cleaved caspase-3 from epidermal lysates of UV-irradiated CPDPL/Rac1-EKO mice kept in the dark and under the photoreactivation lamp. GAPDH was used as a loading control. Numbers on the left denote molecular weight in kDa. (b,d, and f) Graphs show quantification of sunburn cells (n=5, 4) (b), cleaved caspase-3 positive cells (n=9, 8) (d) and densitometric analysis of cleaved caspase-3 western blots (n=4, 6) (f) from UV-irradiated CPDPL/Rac1-EKO mice kept in the dark (black bars) and under the photoreactivation (PR) lamp (gray bars). Error bars show S.D. Asterisks show P-value. **<0.01, ***<0.001 Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/28277539), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Guinea Pig Caspase-3 by Immunohistochemistry View Larger

Detection of Guinea Pig Caspase-3 by Immunohistochemistry Representative sections of the medial side of right tibial epiphysis stained with/without caspase-3. Sections stained with caspase-3 antibody at four different time points (DH: A, C, E and G; BS2: B, D, F and H); a higher magnification (I); the growth plate (J) and fibrocartilage of anterior cruciate ligament (K) show caspase-3 positive cells (red cytoplasmic staining; arrow). A negative control section is shown in (L). Image collected and cropped by CiteAb from the following publication (https://www.mdpi.com/1422-0067/14/9/17729), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Mouse Caspase-3 by Immunohistochemistry View Larger

Detection of Mouse Caspase-3 by Immunohistochemistry DNA damage has an important role in increased UV-light-induced keratinocyte apoptosis in Rac1-EKO epidermis in vivo. (a and c) H/E stainings and immunostainings against cleaved caspase-3 (green) of UV-irradiated skin of CPDPL/Rac1-EKO mice kept in the dark and under the photoreactivation lamp. Nuclei are stained in blue. Dashed line in c demarcates border between epidermis and dermis. Scale bar=100 μm. (e) Western blot analysis of cleaved caspase-3 from epidermal lysates of UV-irradiated CPDPL/Rac1-EKO mice kept in the dark and under the photoreactivation lamp. GAPDH was used as a loading control. Numbers on the left denote molecular weight in kDa. (b,d, and f) Graphs show quantification of sunburn cells (n=5, 4) (b), cleaved caspase-3 positive cells (n=9, 8) (d) and densitometric analysis of cleaved caspase-3 western blots (n=4, 6) (f) from UV-irradiated CPDPL/Rac1-EKO mice kept in the dark (black bars) and under the photoreactivation (PR) lamp (gray bars). Error bars show S.D. Asterisks show P-value. **<0.01, ***<0.001 Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/28277539), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Guinea Pig Caspase-3 by Immunohistochemistry View Larger

Detection of Guinea Pig Caspase-3 by Immunohistochemistry Representative sections of the medial side of right tibial epiphysis stained with/without caspase-3. Sections stained with caspase-3 antibody at four different time points (DH: A, C, E and G; BS2: B, D, F and H); a higher magnification (I); the growth plate (J) and fibrocartilage of anterior cruciate ligament (K) show caspase-3 positive cells (red cytoplasmic staining; arrow). A negative control section is shown in (L). Image collected and cropped by CiteAb from the following publication (https://www.mdpi.com/1422-0067/14/9/17729), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Mouse Caspase-3 by Immunohistochemistry View Larger

Detection of Mouse Caspase-3 by Immunohistochemistry Immunohistochemical staining for caspase 3 on surgically transected tumours. A) Epo-treated tumour 24 hours after surgery. B) Placebo-treated tumour 24 hours after surgery. C) Placebo-treated tumour 48 hours after surgery Image collected and cropped by CiteAb from the following publication (https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-14-648), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Guinea Pig Caspase-3 by Immunohistochemistry View Larger

Detection of Guinea Pig Caspase-3 by Immunohistochemistry Representative sections of the medial side of right tibial epiphysis stained with/without caspase-3. Sections stained with caspase-3 antibody at four different time points (DH: A, C, E and G; BS2: B, D, F and H); a higher magnification (I); the growth plate (J) and fibrocartilage of anterior cruciate ligament (K) show caspase-3 positive cells (red cytoplasmic staining; arrow). A negative control section is shown in (L). Image collected and cropped by CiteAb from the following publication (https://www.mdpi.com/1422-0067/14/9/17729), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse Caspase-3 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse Caspase-3 by Immunocytochemistry/Immunofluorescence Smad1 deletion reduces oxidative stress and apoptosis following stroke.(A) Fluorescent images and quantification of in vivo HEt assay reflecting ROS levels on the ipsilateral hemisphere at 7 days post-stroke. The extent of oxidized nucleotides was measured by IHC for 8-oxo-dG levels at 24 h post-stroke. (B) IHC and quantification of activated Caspase 3 (aCasp3) and p53 on ipsilateral hemisphere at 7 days post-stroke. n = 3 for HEt, 8-oxo-dG, aCasp3, n = 4 for p53, unpaired Student’s t-test, *p<0.05; ***p<0.001. Scale, 50 μm. Image collected and cropped by CiteAb from the following publication (https://dx.plos.org/10.1371/journal.pone.0136967), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Canine Caspase-3 by Western Blot View Larger

Detection of Canine Caspase-3 by Western Blot Effects of IGF-1 or/and PDGF-bb on IL-1 beta -induced NF-kappa B-dependent pro-inflammatory, pro-apoptotic and matrix degrading gene products in chondrocytes.To determine whether IGF-1 or/and PDGF-bbexert effects on IL-1 beta -induced NF-kappa B-dependent expression of pro-inflammatory, pro-apoptotic and matrix degrading gene products, primary chondrocytes were either stimulated with 10 ng/ml IL-1 beta, 10 ng/ml PDGF-bb, 10 ng/ml IGF-1 or combination of both growth factors (5 ng/ml each) or pre-stimulated for 12 h with 10 ng/ml PDGF-bb, 10 ng/ml IGF-1 or combination of both growth factors (5 ng/ml each) followed by 10 ng/ml IL-1 beta for 24. Equal amounts of total proteins were separated by SDS-PAGE and analyzed by immunoblotting using antibodies raised against COX-2, MMP-9 and MMP-13 and active caspase-3. Stimulation with IL-1 beta resulted in production of COX-2, MMP-9, MMP-13 and caspase-3 cleavage. Pre-treatment with a combination of both IGF-1 or/and PDGF-bb downregulated COX-2, MMP-9, MMP-13 and cleaved caspase-3. Image collected and cropped by CiteAb from the following publication (https://dx.plos.org/10.1371/journal.pone.0028663), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Human Human/Mouse Active Caspase-3 Antibody by Immunohistochemistry View Larger

Detection of Human Human/Mouse Active Caspase-3 Antibody by Immunohistochemistry Double immunofluorescent staining of FSGS kidneys to Ki-67, alpha -tubulin and DAPI or double immunofluorescent staining to caspase-3 and DAPI. A. FSGS kidneys: cysts with simple squamous epithelium (CS) filled with colloid content, interstitium (i) and collecting tubules (ct) contain Ki-67-positive cells (arrows)(square). B. alpha -tubulin visualizes short cilia (arrows) in the cysts and extremely long cilia in collecting tubules (arrows)(square). C. Nuclear DAPI stain. D. Merging of A + B + C shows relationships between proliferating cells (green) and cilia (red). Immunostaining to Ki-67, alpha -tubulin and DAPI; scale bar 10 μm. E. Distribution of Ki-67 positive cells (%) in CNF and FSGS nephrotic syndrome. Cysts of proximal tubules with simple squamous epithelium (CS) or simple cuboidal epithelium (CC), proximal tubules with apparently normal simple cuboidal/columnar epithelium (PTNC). Data are shown as mean ± SD. Significant differences (Kruskal–Wallis) indicated by ***p < 0.0001. F. FSGS kidneys: caspase-3-positive apoptotic cells (arrows) in proximal tubules (PTNC) and interstitium (i). G. Nuclear DAPI stain. H. Merging of F + G shows green caspase-3- positive apoptotic nuclei and blue non-apoptotic nuclei. Immunostaining to caspase-3 and DAPI, scale bar 10 μm. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/24397250), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Guinea Pig Human/Mouse Active Caspase-3 Antibody by Immunohistochemistry View Larger

Detection of Guinea Pig Human/Mouse Active Caspase-3 Antibody by Immunohistochemistry Representative sections of the medial side of right tibial epiphysis stained with/without caspase-3. Sections stained with caspase-3 antibody at four different time points (DH: A, C, E and G; BS2: B, D, F and H); a higher magnification (I); the growth plate (J) and fibrocartilage of anterior cruciate ligament (K) show caspase-3 positive cells (red cytoplasmic staining; arrow). A negative control section is shown in (L). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/23994836), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Guinea Pig Human/Mouse Active Caspase-3 Antibody by Immunohistochemistry View Larger

Detection of Guinea Pig Human/Mouse Active Caspase-3 Antibody by Immunohistochemistry Representative sections of the medial side of right tibial epiphysis stained with/without caspase-3. Sections stained with caspase-3 antibody at four different time points (DH: A, C, E and G; BS2: B, D, F and H); a higher magnification (I); the growth plate (J) and fibrocartilage of anterior cruciate ligament (K) show caspase-3 positive cells (red cytoplasmic staining; arrow). A negative control section is shown in (L). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/23994836), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Canine Human/Mouse Active Caspase-3 Antibody by Western Blot View Larger

Detection of Canine Human/Mouse Active Caspase-3 Antibody by Western Blot Effects of IGF-1 or/and PDGF-bb on IL-1 beta -induced NF-kappa B-dependent pro-inflammatory, pro-apoptotic and matrix degrading gene products in chondrocytes.To determine whether IGF-1 or/and PDGF-bbexert effects on IL-1 beta -induced NF-kappa B-dependent expression of pro-inflammatory, pro-apoptotic and matrix degrading gene products, primary chondrocytes were either stimulated with 10 ng/ml IL-1 beta, 10 ng/ml PDGF-bb, 10 ng/ml IGF-1 or combination of both growth factors (5 ng/ml each) or pre-stimulated for 12 h with 10 ng/ml PDGF-bb, 10 ng/ml IGF-1 or combination of both growth factors (5 ng/ml each) followed by 10 ng/ml IL-1 beta for 24. Equal amounts of total proteins were separated by SDS-PAGE and analyzed by immunoblotting using antibodies raised against COX-2, MMP-9 and MMP-13 and active caspase-3. Stimulation with IL-1 beta resulted in production of COX-2, MMP-9, MMP-13 and caspase-3 cleavage. Pre-treatment with a combination of both IGF-1 or/and PDGF-bb downregulated COX-2, MMP-9, MMP-13 and cleaved caspase-3. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/22194879), licensed under a CC-BY license. Not internally tested by R&D Systems.

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Background: Caspase-3

Caspase-3 (Cysteine-aspartic acid protease 3/Casp3; also Yama, apopain and CPP32) is a 29 kDa heterodimer that belongs to the peptidase C14A family of enzymes. It is widely expressed, and considered to be the major executioner caspase in the apoptotic cascade. Human procaspase-3 is a 32 kDa, 277 amino acid (aa) protein and is normally an inactive homodimer. Following cell stress/activation, procaspase-3 undergoes proteolysis to generate an N-terminal 148 aa p17/17 kDa subunit (aa 29-175), plus a 102 aa C-terminal p12/12 kDa subunit. These subunits noncovalently heterodimerize, and associate with another p17/p12 heterodimer to form an active enzyme. There is one potential variant that shows an alternative start site nine aa upstream of the standard start site coupled with a 21 aa substitution for aa 162-277. Over aa 29-175, human and mouse caspase-3 share 87% aa identity.

Entrez Gene IDs
836 (Human); 12367 (Mouse)
Alternate Names
Apopain; apoptosis-related cysteine protease; CASP3; CASP-3; caspase 3, apoptosis-related cysteine peptidase; Caspase3; Caspase-3; CPP32; CPP-32; CPP32B; CPP32SREBP cleavage activity 1; Cysteine protease CPP32; EC 3.4.22; EC 3.4.22.56; LICE-1; PARP cleavage protease; procaspase3; Protein Yama; SCA-1; YAMA

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Citations for Human/Mouse Active Caspase-3 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

389 Citations: Showing 1 - 10
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  1. DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma
    Authors: Thale Kristin Olsen, Cecilia Dyberg, Bethel Tesfai Embaie, Adele Alchahin, Jelena Milosevic, Jane Ding et al.
    JCI Insight
  2. TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3
    Authors: Raquel Espín, Francisco J. Roca, Sergio Candel, María P. Sepulcre, Juan M. González-Rosa, Francisca Alcaraz-Pérez et al.
    Disease Models & Mechanisms
  3. Methyl Gallate Suppresses Tumor Development by Increasing Activation of Caspase3 and Disrupting Tumor Angiogenesis in Melanoma
    Authors: Jeong-Ki Park, Min-Jae Yoo, Hyuk Jang, Sang-Youel Park, Jawun Choi, Jae-Won Seol
    Evidence-Based Complementary and Alternative Medicine
  4. An Atoh1-S193A Phospho-Mutant Allele Causes Hearing Deficits and Motor Impairment
    Authors: Wei Rose Xie, Hsin-I Jen, Michelle L. Seymour, Szu-Ying Yeh, Fred A. Pereira, Andrew K. Groves et al.
    The Journal of Neuroscience
  5. Retinal inflammation in murine models of type 1 and type 2 diabetes with diabetic retinopathy
    Authors: Subramanian Dharmarajan, Casandra Carrillo, Zhonghua Qi, Jonathan M. Wilson, Anthony J. Baucum, Christine M. Sorenson et al.
    Diabetologia
  6. All-trans retinoic acid attenuates isoproterenol-induced cardiac dysfunction through Crabp1 to dampen CaMKII activation
    Authors: Sung Wook Park, Jennifer Nhieu, Yi-Wei Lin, Li-Na Wei
    European Journal of Pharmacology
  7. A transgenic toolkit for visualizing and perturbing microtubules reveals unexpected functions in the epidermis
    Authors: Andrew Muroyama, Terry Lechler
    eLife
  8. RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis
    Authors: Marius Dannappel, Katerina Vlantis, Snehlata Kumari, Apostolos Polykratis, Chun Kim, Laurens Wachsmuth et al.
    Nature
  9. Overexpression of factor VIII after AAV delivery is transiently associated with cellular stress in hemophilia A mice
    Authors: Amy M Lange, Ekaterina S Altynova, Giang N Nguyen, Denise E Sabatino
    Molecular Therapy - Methods & Clinical Development
  10. Inhibitory Effect of a gamma -Tocopherol-Rich Mixture of Tocopherols on the Formation and Growth of LNCaP Prostate Tumors in Immunodeficient Mice
    Authors: Xi Zheng, Xiao-Xing Cui, Tin Oo Khor, Ying Huang, Robert S DiPaola, Susan Goodin et al.
    Cancers (Basel)
  11. Homeodomain Interacting Protein Kinase 2 Regulates Postnatal Development of Enteric Dopaminergic Neurons and Glia via BMP Signaling
    Authors: Alcmène Chalazonitis, Amy A. Tang, Yulei Shang, Tuan D. Pham, Ivy Hsieh, Wanda Setlik et al.
    The Journal of Neuroscience
  12. Endothelin 1-induced retinal ganglion cell death is largely mediated by JUN activation
    Authors: Olivia J. Marola, Stephanie B. Syc-Mazurek, Gareth R. Howell, Richard T. Libby
    Cell Death & Disease
  13. Bimodal function of chromatin remodeler Hmga1 in neural crest induction and Wnt-dependent emigration
    Authors: Shashank Gandhi, Erica J Hutchins, Krystyna Maruszko, Jong H Park, Matthew Thomson, Marianne E Bronner
    eLife
  14. The chicken cornea as a model of wound healing and neuronal re-innervation
    Authors: Eric R. Ritchey, Kimberly Code, Christopher P. Zelinka, Melissa A. Scott, Andy J. Fischer
    Mol Vis
  15. beta1-Integrin plays a major role in resveratrol-mediated anti-invasion effects in the CRC microenvironment
    Authors: A Brockmuell, AL Mueller, P Shayan, M Shakibaei
    Frontiers in Pharmacology, 2022-09-02;13(0):978625.
  16. A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide
    Authors: Jonathan M. Williams, Carrie A. Duckworth, Alastair J. M. Watson, Mark R. Frey, Jennifer C. Miguel, Michael D. Burkitt et al.
    Disease Models & Mechanisms
  17. Leukocyte Receptor Tyrosine Kinase interacts with secreted midkine to promote survival of migrating neural crest cells.
    Authors: Vieceli FM, Bronner ME.
    Development
  18. Injury-induced perivascular niche supports alternative differentiation of adult rodent CNS progenitor cells
    Authors: Justyna Ulanska-Poutanen, Jakub Mieczkowski, Chao Zhao, Katarzyna Konarzewska, Beata Kaza, Hartmut BF Pohl et al.
    eLife
  19. LIM-Homeodomain Transcription Factor LHX4 Is Required for the Differentiation of Retinal Rod Bipolar Cells and OFF-Cone Bipolar Subtypes
    Authors: Xuhui Dong, Hua Yang, Xiangtian Zhou, Xiaoling Xie, Dongliang Yu, Luming Guo et al.
    Cell Reports
  20. Neuronal changes and cognitive deficits in a multi-hit rat model following cumulative impact of early life stressors
    Authors: Tiyasha Sarkar, Nisha Patro, Ishan Kumar Patro
    Biology Open
  21. TNF-alpha-induced mitochondrial alterations in human T cells requires FADD and caspase-8 activation but not RIP and caspase-3 activation
    Authors: Mehdi Shakibaei, Bokyung Sung, Gautam Sethi, Bharat B. Aggarwal
    Antioxidants & Redox Signaling
  22. Chromatin Remodeler Znhit1 Controls Bone Morphogenetic Protein Signaling in Embryonic Lung Tissue Branching
    Authors: W Wei, X Tang, N Jiang, C Ni, H He, S Sun, M Yu, C Yu, M Qiu, D Yan, Z Zhou, Y Song, H Liu, B Zhao, X Lin
    The Journal of Biological Chemistry, 2022-09-14;0(0):102490.
  23. Tumor necrosis factor-inducible gene 6 protein ameliorates chronic liver damage by promoting autophagy formation in mice
    Authors: Sihyung Wang, Chanbin Lee, Jieun Kim, Jeongeun Hyun, Minso Lim, Hyuk-Jin Cha et al.
    Experimental & Molecular Medicine
  24. Respiratory and Olfactory Cytotoxicity of Inhaled 2,3-Pentanedione in Sprague-Dawley Rats
    Authors: Ann F. Hubbs, Amy M. Cumpston, W. Travis Goldsmith, Lori A. Battelli, Michael L. Kashon, Mark C. Jackson et al.
    The American Journal of Pathology
  25. A single administration of combination therapy inhibits breast tumour progression in bone and modifies both osteoblasts and osteoclasts
    Authors: H.K. Brown, P.D. Ottewell, C.A. Evans, R.E. Coleman, I. Holen
    Journal of Bone Oncology
  26. Rapid remodeling of airway vascular architecture at birth.
    Authors: Ni A, Lashnits E, Yao LC et al.
    Dev Dyn
  27. Cardiac neural crest contributes to cardiomyocytes in amniotes and heart regeneration in zebrafish
    Authors: Weiyi Tang, Megan L Martik, Yuwei Li, Marianne E Bronner
    eLife
  28. Autonomic Dysreflexia Causes Chronic Immune Suppression after Spinal Cord Injury
    Authors: Y. Zhang, Zhen Guan, Brenda Reader, Todd Shawler, Shweta Mandrekar-Colucci, Kun Huang et al.
    Journal of Neuroscience
  29. UV-induced reduction in Polycomb repression promotes epidermal pigmentation
    Authors: Li MY, Flora P, Pu H Et al.
    Developmental cell
  30. Deconstructing the perineuronal net: Cellular contributions and molecular composition of the neuronal extracellular matrix
    Authors: K. A. Giamanco, R. T. Matthews
    Neuroscience
  31. m6A RNA methylation impacts fate choices during skin morphogenesis
    Authors: Linghe Xi, Thomas Carroll, Irina Matos, Ji-Dung Luo, Lisa Polak, H Amalia Pasolli et al.
    eLife
  32. Extrinsic mechanical forces mediate retrograde axon extension in a developing neuronal circuit
    Authors: M. A. Breau, I. Bonnet, J. Stoufflet, J. Xie, S. De Castro, S. Schneider-Maunoury
    Nature Communications
  33. Targeting autophagy enhances the anti-tumoral action of crizotinib in ALK-positive anaplastic large cell lymphoma
    Authors: Géraldine Mitou, Julie Frentzel, Aurore Desquesnes, Sophie Le Gonidec, Talal AlSaati, Isabelle Beau et al.
    Oncotarget
  34. Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway
    Authors: Constanze Buhrmann, Ali Mobasheri, Franziska Busch, Constance Aldinger, Ralf Stahlmann, Azadeh Montaseri et al.
    Journal of Biological Chemistry
  35. Compartment specific responses to contractility in the small intestinal epithelium
    Authors: Taylor Hinnant, Wenxiu Ning, Terry Lechler
    bioRxiv
  36. Constraint of gene expression by the chromatin remodelling protein CHD4 facilitates lineage specification
    Authors: Aoife O'Shaughnessy-Kirwan, Jason Signolet, Ita Costello, Sarah Gharbi, Brian Hendrich
    Development
  37. Thermal dose fractionation affects tumour physiological response
    Authors: Donald E. Thrall, Paolo Maccarini, Paul Stauffer, James Macfall, Marlene Hauck, Stacey Snyder et al.
    International Journal of Hyperthermia
  38. Expression Pattern of 5-HT (Serotonin) Receptors during Normal Development of the Human Spinal Cord and Ganglia and in Fetus with Cervical Spina Bifida
    Authors: Hrvoje Punda, Snjezana Mardesic, Natalija Filipovic, Ivona Kosovic, Benjamin Benzon, Marin Ogorevc et al.
    International Journal of Molecular Sciences
  39. Lamin A/C Ablation Restricted to Vascular Smooth Muscle Cells, Cardiomyocytes, and Cardiac Fibroblasts Causes Cardiac and Vascular Dysfunction
    Authors: Del Monte-Monge, A;Ruiz-Polo de Lara, Í;Gonzalo, P;Espinós-Estévez, C;González-Amor, M;de la Fuente-Pérez, M;Andrés-Manzano, MJ;Fanjul, V;Gimeno, JR;Barriales-Villa, R;Dorado, B;Andrés, V;
    International journal of molecular sciences
  40. Method for Novel Anti-Cancer Drug Development using Tumor Explants of Surgical Specimens
    Authors: Kaushal Joshi, Habibe Demir, Ryosuke Yamada, Takeshi Miyazaki, Abhik Ray-Chaudhury, Ichiro Nakano
    Journal of Visualized Experiments
  41. Distinct Responses to Hypoxia in Subpopulations of Distal Pulmonary Artery Cells Contribute to Pulmonary Vascular Remodeling in Emphysema
    Authors: L. S. Howard, A. Crosby, P. Vaughan, A. Sobolewski, M. Southwood, M. L. Foster et al.
    Pulmonary Circulation
  42. Resveratrol induces apoptosis by modulating the reciprocal crosstalk between p53 and Sirt-1 in the CRC tumor microenvironment
    Authors: Aranka Brockmueller, Constanze Buhrmann, Parviz Shayan, Mehdi Shakibaei
    Frontiers in Immunology
  43. Skin vasculature and hair follicle cross-talking associated with stem cell activation and tissue homeostasis
    Authors: Kefei Nina Li, Prachi Jain, Catherine Hua He, Flora Chae Eun, Sangjo Kang, Tudorita Tumbar
    eLife
  44. Development of a Lung Cancer Therapeutic Based on the Tumor Suppressor MicroRNA-34
    Authors: Jason F. Wiggins, Lynnsie Ruffino, Kevin Kelnar, Michael Omotola, Lubna Patrawala, David Brown et al.
    Cancer Research
  45. Lumbar spine intrathecal transplantation of neural precursor cells promotes oligodendrocyte proliferation in hot spots of chronic demyelination
    Authors: Paschalis Theotokis, Evangelia Kesidou, Dimitra Mitsiadou, Steven Petratos, Olympia Damianidou, Marina Boziki et al.
    Brain Pathology
  46. EDA2R mediates podocyte injury in high glucose milieu
    Authors: Xiqian Lan, Vinod Kumar, Alok Jha, Rukhsana Aslam, Haichao Wang, Kehong Chen et al.
    Biochimie
  47. NF-kappa B1, NF-kappa B2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice
    Authors: Michael D Burkitt, Abdalla F Hanedi, Carrie A Duckworth, Jonathan M Williams, Joseph M Tang, Lorraine A O'Reilly et al.
    The Journal of Pathology
  48. Apoptosis in Normal and Coxiella burnetii–Infected Placentas From Alaskan Northern Fur Seals (Callorhinus ursinus)
    Authors: E. Myers, E. J. Ehrhart, B. Charles, T. Spraker, T. Gelatt, C. Duncan
    Veterinary Pathology
  49. Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation
    Authors: Jason Wray, Tüzer Kalkan, Sandra Gomez-Lopez, Dominik Eckardt, Andrew Cook, Rolf Kemler et al.
    Nature Cell Biology
  50. Chronic lung disease in preterm lambs: effect of daily vitamin A treatment on alveolarization
    Authors: Kurt H. Albertine, Mar Janna Dahl, Linda W. Gonzales, Zheng-ming Wang, Drew Metcalfe, Dallas M. Hyde et al.
    American Journal of Physiology-Lung Cellular and Molecular Physiology
  51. Curcumin mediated suppression of nuclear factor-kappa B promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment
    Authors: Constanze Buhrmann, Ali Mobasheri, Ulrike Matis, Mehdi Shakibaei
    Arthritis Research & Therapy
  52. Shear stimulation of FOXC1 and FOXC2 differentially regulates cytoskeletal activity during lymphatic valve maturation
    Authors: Pieter R Norden, Amélie Sabine, Ying Wang, Cansaran Saygili Demir, Ting Liu, Tatiana V Petrova et al.
    eLife
  53. Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion
    Authors: Naoto Kawakami, U. Valentin Nägerl, Francesca Odoardi, Tobias Bonhoeffer, Hartmut Wekerle, Alexander Flügel
    The Journal of Experimental Medicine
  54. Effects of indole-3-carbinol on steroid hormone profile and tumor progression in a mice model of canine inflammatory mammarycancer
    Authors: A Martín-Rui, L Peña, A González-G, LT Díez-Córdo, S Cáceres, JC Illera
    BMC Cancer, 2018-06-04;18(1):626.
  55. Differential response of flat and polypoid colitis-associated colorectal neoplasias to chemopreventive agents and heterocyclic amines
    Authors: Wen-Chi L. Chang, Terry V. Zenser, Harry S. Cooper, Margie L. Clapper
    Cancer Letters
  56. Targeting the angiotensin II type 2 receptor (AT2R) in colorectal liver metastases
    Authors: Eleanor I Ager, Way W Chong, Shu-wen Wen, Christopher Christophi
    Cancer Cell International
  57. 3D Printed Bioreactor Enabling the Pulsatile Culture of Native and Angioplastied Large Arteries
    Authors: Rolando S. Matos, Davide Maselli, John H. McVey, Christian Heiss, Paola Campagnolo
    Frontiers in Cardiovascular Medicine
  58. Testing the efficacy of a human full-length OPG-Fc analog in a severe model of cardiotoxin-induced skeletal muscle injury and repair
    Authors: Zineb Bouredji, Dounia Hamoudi, Laetitia Marcadet, Anteneh Argaw, Jérôme Frenette
    Molecular Therapy - Methods & Clinical Development
  59. Notch-mediated lateral induction is necessary to maintain vestibular prosensory identity during inner ear development
    Authors: Rogers M. Brown, Joel C. Nelson, Hongyuan Zhang, Amy E. Kiernan, Andrew K. Groves
    Developmental Biology
  60. Extracellular vesicle release from intestinal organoids is modulated by Apc mutation and other colorectal cancer progression factors
    Authors: Zsuzsanna Szvicsek, Ádám Oszvald, Lili Szabó, Gyöngyvér Orsolya Sándor, Andrea Kelemen, András Áron Soós et al.
    Cellular and Molecular Life Sciences
  61. DNA Methyltransferase 1 Is Indispensable for Development of the Hippocampal Dentate Gyrus
    Authors: Hirofumi Noguchi
    J Neurosci, 2016-06-01;36(22):6050-68.
  62. Expression of DNMT1 in neural stem/precursor cells is critical for survival of newly generated neurons in the adult hippocampus
    Authors: Hirofumi Noguchi, Ayaka Kimura, Naoya Murao, Taito Matsuda, Masakazu Namihira, Kinichi Nakashima
    Neuroscience Research
  63. Fibroblast growth factor receptor 3 activation plays a causative role in urothelial cancer pathogenesis in cooperation with Pten loss in mice
    Authors: Mona Foth, Imran Ahmad, Bas W. G. van Rhijn, Theodorus van der Kwast, Andre M. Bergman, Louise King et al.
    The Journal of Pathology
  64. PIDD orchestrates translesion DNA synthesis in response to UV irradiation
    Authors: E Logette, S Schuepbach-Mallepell, M J Eckert, X H Leo, B Jaccard, C Manzl et al.
    Cell Death & Differentiation
  65. Immunohistochemical Analysis of the Spinal Cord Ischemia– Effect of Remote Ischemic Preconditioning in a Porcine Model
    Authors: Henri Johannes Haapanen, Johanna Herajärvi, Hannu-Pekka Honkanen, Caius Mustonen, Hannu Tuominen, Ulla Puistola et al.
    The Heart Surgery Forum
  66. Nivalenol Has a Greater Impact than Deoxynivalenol on Pig Jejunum Mucosa in Vitro on Explants and in Vivo on Intestinal Loops
    Authors: Sophal Cheat, Juliana R. Gerez, Juliette Cognié, Imourana Alassane-Kpembi, Ana Paula F. L. Bracarense, Isabelle Raymond-Letron et al.
    Toxins (Basel)
  67. Blast-Associated Shock Waves Result in Increased Brain Vascular Leakage and Elevated ROS Levels in a Rat Model of Traumatic Brain Injury
    Authors: Shushi Kabu, Hayder Jaffer, Marianne Petro, Dave Dudzinski, Desiree Stewart, Amy Courtney et al.
    PLOS ONE
  68. c-Raf, but Not B-Raf, Is Essential for Development of K-Ras Oncogene-Driven Non-Small Cell Lung Carcinoma
    Authors: Rafael B. Blasco, Sarah Francoz, David Santamaría, Marta Cañamero, Pierre Dubus, Jean Charron et al.
    Cancer Cell
  69. Epiboly generates the epidermal basal monolayer and spreads the nascent mammalian skin to enclose the embryonic body
    Authors: Eleni Panousopoulou, Carl Hobbs, Ivor Mason, Jeremy B. A. Green, Caroline J. Formstone
    Development
  70. Hepatoprotective Effect of Kombucha Tea in Rodent Model of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis
    Authors: Chanbin Lee, Jieun Kim, Sihyung Wang, Sumi Sung, Namgyu Kim, Hyun-Hee Lee et al.
    International Journal of Molecular Sciences
  71. A Non-Specific Effect Associated with Conditional Transgene Expression Based on Cre-loxP Strategy in Mice
    Authors: Linghua Qiu, Jaime A. Rivera-Pérez, Zuoshang Xu
    PLoS ONE
  72. Epiboly generates the epidermal basal monolayer and spreads the nascent mammalian skin to enclose the embryonic body
    Authors: Eleni Panousopoulou, Carl Hobbs, Ivor Mason, Jeremy B. A. Green, Caroline J. Formstone
    Journal of Cell Science
  73. Notch signaling is active in normal mouse middle ear epithelial cells
    Authors: XIANG LIU, HAI-BIN SHENG, RUI MA, JUAN-MEI YANG, WEN-WEI LUO, XIAO-YU YANG et al.
    Experimental and Therapeutic Medicine
  74. Effects of Maternal Dexamethasone Treatment Early in Pregnancy on Glucocorticoid Receptors in the Ovine Placenta
    Authors: H. Shang, W. Meng, D. M. Sloboda, S. Li, L. Ehrlich, A. Plagemann et al.
    Reproductive Sciences
  75. Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines
    Authors: Hayley Davis, Annabelle Lewis, Axel Behrens, Ian Tomlinson
    Gut
  76. The early life microbiota protects neonatal mice from pathological small intestinal epithelial cell shedding
    Authors: Hughes KR, Schofield Z, Dalby MJ et al.
    FASEB J
  77. Evidence That beta 1-Integrin Is Required for the Anti-Viability and Anti-Proliferative Effect of Resveratrol in CRC Cells
    Authors: Aranka Brockmueller, Parviz Shayan, Mehdi Shakibaei
    International Journal of Molecular Sciences
  78. Atypical E2Fs either Counteract or Cooperate with RB during Tumorigenesis Depending on Tissue Context
    Authors: Eva Moreno, Shusil K. Pandit, Mathilda J. M. Toussaint, Laura Bongiovanni, Liesbeth Harkema, Saskia C. van Essen et al.
    Cancers (Basel)
  79. Cdh11 Acts as a Tumor Suppressor in a Murine Retinoblastoma Model by Facilitating Tumor Cell Death
    Authors: Mellone N. Marchong, Christine Yurkowski, Clement Ma, Clarellen Spencer, Sanja Pajovic, Brenda L. Gallie
    PLoS Genetics
  80. Single-cell transcriptomic atlas of lung microvascular regeneration after targeted endothelial cell ablation
    Authors: Rafael Soares Godoy, Nicholas D Cober, David P Cook, Emma McCourt, Yupu Deng, Liyuan Wang et al.
    eLife
  81. Assessing the Radiation Response of Lung Cancer with Different Gene Mutations Using Genetically Engineered Mice
    Authors: Bradford A. Perez, A. Paiman Ghafoori, Chang-Lung Lee, Samuel M. Johnston, Yifan Li, Jacob G. Moroshek et al.
    Frontiers in Oncology
  82. T Regulatory Cells Control Susceptibility to Invasive Pneumococcal Pneumonia in Mice
    Authors: Daniel R. Neill, Vitor E. Fernandes, Laura Wisby, Andrew R. Haynes, Daniela M. Ferreira, Ameera Laher et al.
    PLoS Pathogens
  83. Vascular derived endothelin receptor A controls endothelin-induced retinal ganglion cell death
    Authors: Olivia J. Marola, Gareth R. Howell, Richard T. Libby
    Cell Death Discovery
  84. Effects of Environmental Conditions on Nephron Number: Modeling Maternal Disease and Epigenetic Regulation in Renal Development
    Authors: Lars Fuhrmann, Saskia Lindner, Alexander-Thomas Hauser, Clemens Höse, Oliver Kretz, Clemens D. Cohen et al.
    International Journal of Molecular Sciences
  85. Spermidine rescues the deregulated autophagic response to oxidative stress of osteoarthritic chondrocytes
    Authors: D'Adamo S, Cetrullo S, Guidotti S et al.
    Free Radic. Biol. Med.
  86. Microwave hyperthermia represses human papillomavirus oncoprotein activity and induces cell death due to cell stress in 3D tissue models of anogenital precancers and cancers
    Authors: Conley MJ, Epifano I, Kirk A et al.
    EBioMedicine
  87. RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury
    Authors: S Krishna-Su, S Singer, M Armaka, JM Banales, K Holzer, P Schirmache, H Walczak, G Kollias, M Pasparakis, V Kondylis
    Cell Death Differ., 2019-04-15;0(0):.
  88. Wee1 inhibition potentiates Wip1-dependent p53-negative tumor cell death during chemotherapy
    Authors: V Clausse, A R Goloudina, B Uyanik, E Y Kochetkova, S Richaud, O A Fedorova et al.
    Cell Death & Disease
  89. Chaperone-Mediated Autophagy Controls Proteomic and Transcriptomic Pathways to Maintain Glioma Stem Cell Activity
    Authors: Jaione Auzmendi-Iriarte, Maddalen Otaegi-Ugartemendia, Estefania Carrasco-Garcia, Mikel Azkargorta, Antonio Diaz, Ander Saenz-Antoñanzas et al.
    Cancer Research
  90. Nuclear PTEN and p53 suppress stress-induced liver cancer through distinct mechanisms
    Authors: Takashi Kato, Daisuke Murata, Robert A. Anders, Hiromi Sesaki, Miho Iijima
    Biochemical and Biophysical Research Communications
  91. Blockade of the renin–angiotensin system inhibits growth of colorectal cancer liver metastases in the regenerating liver
    Authors: Shir Lin Koh, E. I. Ager, P. L. N. Costa, C. Malcontenti-Wilson, V. Muralidharan, C. Christophi
    Clinical & Experimental Metastasis
  92. Synergistic effects of dexamethasone and quinolones on human-derived tendon cells
    Authors: Judith Sendzik, Mehdi Shakibaei, Monika Schäfer-Korting, Hartmut Lode, Ralf Stahlmann
    International Journal of Antimicrobial Agents
  93. Epidermal Rac1 regulates the DNA damage response and protects from UV-light-induced keratinocyte apoptosis and skin carcinogenesis
    Authors: J Deshmukh, R Pofahl, I Haase
    Cell Death Dis, 2017-03-09;8(3):e2664.
  94. Bcl-2 is a critical mediator of intestinal transformation
    Authors: Maartje van der Heijden, Cheryl D. Zimberlin, Anna M. Nicholson, Selcuk Colak, Richard Kemp, Sybren L. Meijer et al.
    Nature Communications
  95. Near infrared fluorescent imaging of choline kinase alpha expression and inhibition in breast tumors
    Authors: Sean P. Arlauckas, Manoj Kumar, Anatoliy V. Popov, Harish Poptani, Edward J. Delikatny
    Oncotarget
  96. Resveratrol Modulates Chemosensitisation to 5-FU via beta1-Integrin/HIF-1alpha Axis in CRC Tumor Microenvironment
    Authors: A Brockmuell, S Girisa, AB Kunnumakka, M Shakibaei
    International Journal of Molecular Sciences, 2023-03-05;24(5):.
  97. Robust neuroinflammation and perivascular pathology in rTg-DI rats, a novel model of microvascular cerebral amyloid angiopathy
    Authors: Zhu X, Hatfield J, Sullivan Jk et Al.
    J Neuroinflammation
  98. Thyroid Hormone Controls Cone Opsin Expression in the Retina of Adult Rodents
    Authors: Anika Glaschke, Jessica Weiland, Domenico Del Turco, Marianne Steiner, Leo Peichl, Martin Glösmann
    The Journal of Neuroscience
  99. RHOJ controls EMT-associated resistance to chemotherapy
    Authors: Debaugnies M, Rodr�guez-Acebes S, Blondeau J et al.
    Nature
  100. Regression of murine lung tumors by the let-7 microRNA
    Authors: Phong Trang, Pedro P. Medina, Jason F. Wiggins, Lynnsie Ruffino, Kevin Kelnar, Michael Omotola et al.
    Oncogene
  101. Motor axon navigation relies on Fidgetin-like 1-driven microtubule plus end dynamics
    Authors: C Fassier, A Fréal, L Gasmi, C Delphin, D Ten Martin, S De Gois, M Tambalo, C Bosc, P Mailly, C Revenu, L Peris, S Bolte, S Schneider-, C Houart, F Nothias, JC Larcher, A Andrieux, J Hazan
    J. Cell Biol., 2018-03-13;0(0):.
  102. Toll-Like Receptor 9 Is a Novel Biomarker for Esophageal Squamous Cell Dysplasia and Squamous Cell Carcinoma Progression
    Authors: Heikki Takala, Joonas H. Kauppila, Ylermi Soini, Katri S. Selander, Katri S. Vuopala, Petri P. Lehenkari et al.
    Journal of Innate Immunity
  103. Interferon-gamma primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway
    Authors: Daniel S. Simpson, Jiyi Pang, Ashley Weir, Isabella Y. Kong, Melanie Fritsch, Maryam Rashidi et al.
    Immunity
  104. Membrane expression of the estrogen receptor ER alpha is required for intercellular communications in the mammary epithelium
    Authors: Laurine Gagniac, Mariam Rusidzé, Frederic Boudou, Stephanie Cagnet, Marine Adlanmerini, Pauline Jeannot et al.
    Development
  105. Butyrate inhibits the proliferation and induces the apoptosis of colorectal cancer HCT116 cells via the deactivation of mTOR/S6K1 signaling mediated partly by SIRT1 downregulation
    Authors: Mingming Cao, Zhuoran Zhang, Su Han, Xi Lu
    Molecular Medicine Reports
  106. Myocardial ischemia/reperfusion impairs neurogenesis and hippocampal-dependent learning and memory
    Authors: Kirsten S. Evonuk, Sumanth D. Prabhu, Martin E. Young, Tara M. DeSilva
    Brain, Behavior, and Immunity
  107. Reduced expression of caspase-8 and cleaved caspase-3 in pancreatic ductal adenocarcinoma cells
    Authors: KATARZYNA JAKUBOWSKA, KATARZYNA GUZIŃSKA-USTYMOWICZ, WALDEMAR FAMULSKI, DARIUSZ CEPOWICZ, DOROTA JAGODZIŃSKA, ANNA PRYCZYNICZ
    Oncology Letters
  108. Tissue plasminogen activator followed by antioxidant-loaded nanoparticle delivery promotes activation/mobilization of progenitor cells in infarcted rat brain
    Authors: Marianne Petro, Hayder Jaffer, Jun Yang, Shushi Kabu, Viola B. Morris, Vinod Labhasetwar
    Biomaterials
  109. Sin3a is essential for the genome integrity and viability of pluripotent cells
    Authors: Patrick McDonel, Jeroen Demmers, David W.M. Tan, Fiona Watt, Brian D. Hendrich
    Developmental Biology
  110. Changes in tissue inflammation, angiogenesis and apoptosis in endometriosis, adenomyosis and uterine myoma after GnRH agonist therapy
    Authors: Khaleque Newaz Khan, Michio Kitajima, Koichi Hiraki, Akira Fujishita, Ichiro Sekine, Tadayuki Ishimaru et al.
    Human Reproduction
  111. Remyelination protects neurons from DLK-mediated neurodegeneration.
    Authors: Duncan, GJ;Ingram, SD;Emberley, K;Hill, J;Cordano, C;Abdelhak, A;McCane, M;Jenks, JE;Jabassini, N;Ananth, K;Ferrara, SJ;Stedelin, B;Sivyer, B;Aicher, SA;Scanlan, TS;Watkins, TA;Mishra, A;Nelson, JW;Green, AJ;Emery, B;
    Nature communications
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  112. Skull bone marrow-derived immune cells infiltrate the injured cerebral cortex and exhibit anti-inflammatory properties
    Authors: Soliman, E;Gudenschwager Basso, EK;Ju, J;Willison, A;Theus, MH;
    Brain, behavior, and immunity
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  113. Non-apical mitoses contribute to cell delamination during mouse gastrulation
    Authors: Despin-Guitard, E;Rosa, VS;Plunder, S;Mathiah, N;Van Schoor, K;Nehme, E;Merino-Aceituno, S;Egea, J;Shahbazi, MN;Theveneau, E;Migeotte, I;
    Nature communications
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  114. Langerhans cells regulate immunity in adulthood by regulating postnatal dermal lymphatic development
    Authors: Sim, JH;Bell, R;Feng, Z;Chyou, S;Shipman, WD;Kataru, RP;Ivashkiv, L;Mehrara, B;Lu, TT;
    bioRxiv : the preprint server for biology
    Species: Mouse, Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  115. Spinal motor neuron development and metabolism are transcriptionally regulated by Nuclear Factor IA
    Authors: Gauberg, J;Moreno, KB;Jayaraman, K;Abumeri, S;Jenkins, S;Salazar, AM;Meharena, HS;Glasgow, SM;
    bioRxiv : the preprint server for biology
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  116. Analysis of gene and protein expression in the endometrium for validation of an ex vivo model of the equine uterus using PCR, digital and visual histopathology
    Authors: Köhne, M;Diel, E;Packeiser, EM;Böttcher, D;Tönissen, A;Unruh, C;Goericke-Pesch, S;Ulrich, R;Sieme, H;
    Theriogenology
    Species: Equine
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  117. Histone lactylation couples cellular metabolism with developmental gene regulatory networks
    Authors: Merkuri, F;Rothstein, M;Simoes-Costa, M;
    Nature communications
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: IHC
  118. Mutation of key signaling regulators of cerebrovascular development in vein of Galen malformations
    Authors: Zhao, S;Mekbib, KY;van der Ent, MA;Allington, G;Prendergast, A;Chau, JE;Smith, H;Shohfi, J;Ocken, J;Duran, D;Furey, CG;Hao, LT;Duy, PQ;Reeves, BC;Zhang, J;Nelson-Williams, C;Chen, D;Li, B;Nottoli, T;Bai, S;Rolle, M;Zeng, X;Dong, W;Fu, PY;Wang, YC;Mane, S;Piwowarczyk, P;Fehnel, KP;See, AP;Iskandar, BJ;Aagaard-Kienitz, B;Moyer, QJ;Dennis, E;Kiziltug, E;Kundishora, AJ;DeSpenza, T;Greenberg, ABW;Kidanemariam, SM;Hale, AT;Johnston, JM;Jackson, EM;Storm, PB;Lang, SS;Butler, WE;Carter, BS;Chapman, P;Stapleton, CJ;Patel, AB;Rodesch, G;Smajda, S;Berenstein, A;Barak, T;Erson-Omay, EZ;Zhao, H;Moreno-De-Luca, A;Proctor, MR;Smith, ER;Orbach, DB;Alper, SL;Nicoli, S;Boggon, TJ;Lifton, RP;Gunel, M;King, PD;Jin, SC;Kahle, KT;
    Nature communications
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  119. Regulation of human and mouse bystander T cell activation responses by PD-1
    Authors: Le, CT;Vick, LV;Collins, C;Dunai, C;Sheng, MK;Khuat, LT;Barao, I;Judge, SJ;Aguilar, EG;Curti, B;Dave, M;Longo, DL;Blazar, BR;Canter, RJ;Monjazeb, AM;Murphy, WJ;
    JCI insight
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  120. Single-Cell Spatial MIST for Versatile, Scalable Detection of Protein Markers
    Authors: Meah, A;Vedarethinam, V;Bronstein, R;Gujarati, N;Jain, T;Mallipattu, SK;Li, Y;Wang, J;
    Biosensors
    Species: Mouse
    Sample Types: Complex Sample Type
    Applications: IHC
  121. Plasticity of thalamocortical axons is regulated by serotonin levels modulated by preterm birth
    Authors: Sinclair-Wilson, A;Lawrence, A;Ferezou, I;Cartonnet, H;Mailhes, C;Garel, S;Lokmane, L;
    Proceedings of the National Academy of Sciences of the United States of America
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  122. Calebin A targets the HIF-1?/NF-?B pathway to suppress colorectal cancer cell migration
    Authors: Brockmueller, A;Girisa, S;Motallebi, M;Kunnumakkara, AB;Shakibaei, M;
    Frontiers in pharmacology
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  123. MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial and ciliary functions by controlling gene promoters
    Authors: Wang, D;Li, H;Chandel, NS;Dou, Y;Yi, R;
    Nature communications
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  124. The kinesin Kif21b regulates radial migration of cortical projection neurons through a non-canonical function on actin cytoskeleton
    Authors: Rivera Alvarez, J;Asselin, L;Tilly, P;Benoit, R;Batisse, C;Richert, L;Batisse, J;Morlet, B;Levet, F;Schwaller, N;Mély, Y;Ruff, M;Reymann, AC;Godin, JD;
    Cell reports
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  125. Organ function is preserved despite reorganization of niche architecture in the hair follicle
    Authors: Wei, H;Du, S;Parksong, J;Pasolli, HA;Matte-Martone, C;Regot, S;Gonzalez, LE;Xin, T;Greco, V;
    Cell stem cell
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  126. Injury prevents Ras mutant cell expansion in mosaic skin
    Authors: Gallini, S;Annusver, K;Rahman, NT;Gonzalez, DG;Yun, S;Matte-Martone, C;Xin, T;Lathrop, E;Suozzi, KC;Kasper, M;Greco, V;
    Nature
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  127. Progressive inflammation reduces high-frequency EEG activity and cortical dendritic arborisation in late gestation fetal sheep
    Authors: Kelly, SB;Dean, JM;Zahra, VA;Dudink, I;Thiel, A;Polglase, GR;Miller, SL;Hooper, SB;Bennet, L;Gunn, AJ;Galinsky, R;
    Journal of neuroinflammation
    Species: Ovine
    Sample Types: Whole Tissue
    Applications: IHC
  128. Mice Mutated in the Third Fibronectin Domain of L1 Show Enhanced Hippocampal Neuronal Cell Death, Astrogliosis and Alterations in Behavior
    Authors: Congiu, L;Granato, V;Jakovcevski, I;Kleene, R;Fernandes, L;Freitag, S;Kneussel, M;Schachner, M;Loers, G;
    Biomolecules
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  129. Human Bone Marrow-Derived Mesenchymal Stromal Cells Reduce the Severity of Experimental Necrotizing Enterocolitis in a Concentration-Dependent Manner
    Authors: L Provitera, A Tomaselli, G Raffaeli, S Crippa, C Arribas, I Amodeo, S Gulden, GS Amelio, V Cortesi, F Manzoni, G Cervellini, J Cerasani, C Menis, N Pesenti, M Tripodi, L Santi, M Maggioni, C Lonati, S Oldoni, F Algieri, F Garrido, ME Bernardo, F Mosca, G Cavallaro
    Cells, 2023-02-27;12(5):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  130. Progenitor-derived endothelin controls dermal sheath contraction for hair follicle regression
    Authors: P Martino, R Sunkara, N Heitman, M Rangl, A Brown, N Saxena, L Grisanti, D Kohan, M Yanagisawa, M Rendl
    Nature Cell Biology, 2023-01-30;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  131. Single cell RNA sequencing analysis of mouse cochlear supporting cell transcriptomes with activated ERBB2 receptor indicates a cell-specific response that promotes CD44 activation
    Authors: D Piekna-Prz, D Na, J Zhang, C Baker, JM Ashton, PM White
    Frontiers in Cellular Neuroscience, 2023-01-06;16(0):1096872.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  132. p53/p21 pathway activation contributes to the ependymal fate decision downstream of GemC1
    Authors: G Ortiz-Álva, A Fortoul, A Srivastava, MX Moreau, B Bouloudi, C Mailhes-Ha, N Delgehyr, M Faucourt, M Bahin, C Blugeon, M Breau, V Géli, F Causeret, A Meunier, N Spassky
    Cell Reports, 2022-12-13;41(11):111810.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  133. Antitumor activity of photodynamic therapy with tetracationic derivative of synthetic bacteriochlorin in spheroid culture of liver and colon cancer cells
    Authors: SS Karshieva, EG Glinskaya, AA Dalina, EV Akhlyustin, EA Makarova, YD Khesuani, NS Chmelyuk, MA Abakumov, DA Khochenkov, VA Mironov, GA Meerovich, EA Kogan, EV Koudan
    Photodiagnosis and photodynamic therapy, 2022-11-15;0(0):103202.
    Species: Human
    Sample Types: Spheroids
    Applications: IHC
  134. Senescence plays a role in Myotonic Dystrophy type 1
    Authors: M García-Pug, A Saenz-Anto, G Gerenu, A Arrieta, R Fernandez-, M Zulaica, A Saenz, J Elizazu, G Nogales-Ga, SM Gadalla, MJ Araúzo-Bra, A Lopez de M, A Matheu
    JCI Insight, 2022-10-10;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  135. Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia
    Authors: EG Vasquez, N Nasreddin, GN Valbuena, EJ Mulholland, HL Belnoue-Da, HR Eggington, RO Schenck, VM Wouters, P Wirapati, K Gilroy, TRM Lannagan, DJ Flanagan, AK Najumudeen, S Omwenga, AMB McCorry, A Easton, VH Koelzer, JE East, D Morton, L Trusolino, T Maughan, AD Campbell, MB Loughrey, PD Dunne, P Tsantoulis, DJ Huels, S Tejpar, OJ Sansom, SJ Leedham
    Cell Stem Cell, 2022-08-04;29(8):1213-1228.e8.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  136. Smooth muscle cell specific NEMO deficiency inhibits atherosclerosis in ApoE-/- mice
    Authors: T Imai, TM Van, M Pasparakis, A Polykratis
    Scientific Reports, 2022-07-22;12(1):12538.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  137. RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer
    Authors: AE Hall, SÖ Pohl, P Cammareri, S Aitken, NT Younger, M Raponi, CV Billard, AB Carrancio, A Bastem, P Freile, F Haward, IR Adams, JF Caceres, P Preyzner, A von Kriegs, MG Dunlop, FV Din, KB Myant
    Nature Communications, 2022-05-19;13(1):2791.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  138. Synovial mesenchymal progenitor derived aggrecan regulates cartilage homeostasis and endogenous repair capacity
    Authors: RJ Krawetz, YE Wu, KL Bertram, A Shonak, AO Masson, G Ren, C Leonard, M Kapoor, JR Matyas, PT Salo
    Cell Death & Disease, 2022-05-18;13(5):470.
    Species: Human, Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  139. Hedgehog Signaling Pathway Orchestrates Human Lung Branching Morphogenesis
    Authors: R Belgacemi, S Danopoulos, G Deutsch, I Glass, V Dormoy, S Bellusci, D Al Alam
    International Journal of Molecular Sciences, 2022-05-09;23(9):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  140. Immunohistochemical Expression of Oxidative Stress and Apoptosis Markers in Archived Liver Specimens from Dogs with Chronic Hepatitis
    Authors: P Yamkate, JA Lidbury, JM Steiner, JS Suchodolsk, PR Giaretta
    Journal of comparative pathology, 2022-04-01;193(0):25-36.
    Species: Canine
    Sample Types: Whole Tissue
    Applications: IHC
  141. Ruscogenins Improve CD-Like Enteritis by Inhibiting Apoptosis of Intestinal Epithelial Cells and Activating Nrf2/NQO1 Pathway
    Authors: H Wen, X Zhang, Q Li, J Huang, G Liu, J Zhao, Y Liu, L Shen, Y Li, K Yang, L Zuo, J Li, J Nian, P Xiang, H Zhao, L Yu, M Liu, Z Geng, X Song
    Oxidative Medicine and Cellular Longevity, 2022-03-10;2022(0):4877275.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC/IF
  142. Angiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells
    Authors: D Chen, ED Hughes, TL Saunders, J Wu, MN Hernández, T Makinen, PD King
    JCI Insight, 2022-02-22;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  143. Formyl peptide receptor 2 determines sex-specific differences in the progression of nonalcoholic fatty liver disease and steatohepatitis
    Authors: C Lee, J Kim, J Han, D Oh, M Kim, H Jeong, TJ Kim, SW Kim, JN Kim, YS Seo, A Suzuki, JH Kim, Y Jung
    Nature Communications, 2022-01-31;13(1):578.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  144. T cell apoptosis characterizes severe Covid-19 disease
    Authors: S André, M Picard, R Cezar, F Roux-Dalva, A Alleaume-B, C Soundaramo, AS Cruz, A Mendes-Fri, C Gotti, M Leclercq, A Nicolas, A Tauzin, A Carvalho, C Capela, J Pedrosa, AG Castro, L Kundura, P Loubet, A Sotto, L Muller, JY Lefrant, C Roger, PG Claret, S Duvnjak, TA Tran, G Racine, O Zghidi-Abo, P Nioche, R Silvestre, A Droit, F Mammano, P Corbeau, J Estaquier
    Cell Death and Differentiation, 2022-01-22;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  145. Polycomb repressive complex 2 in adult hair follicle stem cells is dispensable for hair regeneration
    Authors: P Flora, MY Li, PM Galbo, M Astorkia, D Zheng, E Ezhkova
    PloS Genetics, 2021-12-14;17(12):e1009948.
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  146. BET Proteins Regulate Expression of Osr1 in Early Kidney Development
    Authors: J Schreiber, N Liaukouska, L Fuhrmann, AT Hauser, M Jung, TB Huber, N Wanner
    Biomedicines, 2021-12-10;9(12):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  147. Peptide backbone modifications of amyloid beta (1-40) impact fibrillation behavior and neuronal toxicity
    Authors: B Schwarze, A Korn, C Höfling, U Zeitschel, M Krueger, S Ro beta ner, D Huster
    Scientific Reports, 2021-12-09;11(1):23767.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  148. Regenerative Polarity of the Fin Ray in Zebrafish Caudal Fin and Related Tissue Formation on the Cut Surface
    Authors: W Nakajima, S Nakanishi, R Hosoya, T Uemoto, S Ohgo, N Wada
    Journal of developmental biology, 2021-11-19;9(4):.
    Species: Zebrafish
    Sample Types: Whole Tissue
    Applications: IHC
  149. Co-activation of Sonic hedgehog and Wnt signaling in murine retinal precursor cells drives ocular lesions with features of intraocular medulloepithelioma
    Authors: M Dottermusc, P Sumis?awsk, J Krevet, M Middelkamp, H Vo beta, B Siebels, H Bartsch, K Sotlar, P Meyer, S Frank, A Korshunov, M Glatzel, U Schüller, JE Neumann
    Oncogenesis, 2021-11-16;10(11):78.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  150. Recapitulating cholangiopathy-associated necroptotic cell death in vitro using human cholangiocyte organoids
    Authors: S Shi, MMA Verstegen, HP Roest, AI Ardisasmit, W Cao, FJM Roos, PE de Ruiter, M Niemeijer, Q Pan, JNM IJzermans, LJW van der La
    Cellular and Molecular Gastroenterology and Hepatology, 2021-10-23;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IF
  151. Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion
    Authors: C Junqueira, R Dariolli, J Haydak, S Kang, T Hannah, RJ Wiener, S DeFronzo, R Tejero, GL Gusella, A Ramakrishn, R Alves Dias, A Wojcinski, S Kesari, L Shen, EA Sobie, JP Rodrigues, EU Azeloglu, H Zou, RH Friedel
    Nature Communications, 2021-10-14;12(1):6019.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  152. USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma
    Authors: EJ Ruiz, A Pinto-Fern, AP Turnbull, L Lan, TM Charlton, HC Scott, A Damianou, G Vere, EM Riising, C Da Costa, WW Krajewski, D Guerin, JD Kearns, S Ioannidis, M Katz, C McKinnon, J O'Connell, N Moncaut, I Rosewell, E Nye, N Jones, C Heride, M Gersch, M Wu, CJ Dinsmore, TR Hammonds, S Kim, D Komander, S Urbe, MJ Clague, BM Kessler, A Behrens
    Elife, 2021-10-12;10(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  153. Sprague Dawley Rats Gaining Weight on a High Energy Diet Exhibit Damage to Taste Tissue Even after Return to a Healthy Diet
    Authors: F Harnischfe, F O'Connell, M Weiss, B Axelrod, A Hajnal, K Czaja, PM Di Lorenzo, R Dando
    Nutrients, 2021-08-31;13(9):.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC
  154. A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis
    Authors: D Pradella, G Deflorian, A Pezzotta, A Di Matteo, E Belloni, D Campolungo, A Paradisi, M Bugatti, W Vermi, M Campioni, A Chiapparin, L Scietti, F Forneris, C Giampietro, N Volf, M Rehman, S Zacchigna, MP Paronetto, A Pistocchi, A Eichmann, P Mehlen, C Ghigna
    Nature Communications, 2021-08-11;12(1):4872.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  155. Umbilical cord blood therapy modulates neonatal hypoxic ischemic brain injury in both females and males
    Authors: TR Penny, Y Pham, AE Sutherland, J Lee, G Jenkin, MC Fahey, SL Miller, CA McDonald
    Scientific Reports, 2021-08-04;11(1):15788.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC
  156. Increased Susceptibility and Intrinsic Apoptotic Signaling in Neurons by Induced HDAC3 Expression
    Authors: HM Schmitt, RL Fehrman, ME Maes, H Yang, LW Guo, CL Schlamp, HR Pelzel, RW Nickells
    Investigative Ophthalmology & Visual Science, 2021-08-02;62(10):14.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  157. Meiotic Silencing in Pigs: A Case Study in a Translocated Azoospermic Boar
    Authors: N Mary, A Calgaro, H Barasc, N Bonnet, S Ferchaud, I Raymond-Le, A Ducos, A Pinton
    Genes, 2021-07-27;12(8):.
    Species: Porcine
    Sample Types: Whole Tissue
    Applications: IHC
  158. Improved Method for Efficient Generation of Functional Neurons from Murine Neural Progenitor Cells
    Authors: A Soni, D Klütsch, X Hu, J Houtman, N Rund, A McCloskey, J Mertens, ST Schafer, H Amin, T Toda
    Cells, 2021-07-26;10(8):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  159. Curcumin Attenuates Environment-Derived Osteoarthritis by Sox9/NF-kB Signaling Axis
    Authors: C Buhrmann, A Brockmuell, AL Mueller, P Shayan, M Shakibaei
    International Journal of Molecular Sciences, 2021-07-16;22(14):.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells
    Applications: ICC, Immunoprecipitation, Western Blot
  160. Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis
    Authors: ML Wegscheid, C Anastasaki, KA Hartigan, OM Cobb, JB Papke, JN Traber, SM Morris, DH Gutmann
    Cell Reports, 2021-07-06;36(1):109315.
    Species: Human
    Sample Types: Organoids
    Applications: IHC
  161. Evidence That Tumor Microenvironment Initiates Epithelial-To-Mesenchymal Transition and Calebin A can Suppress it in Colorectal Cancer Cells
    Authors: C Buhrmann, A Brockmuell, C Harsha, AB Kunnumakka, P Kubatka, BB Aggarwal, M Shakibaei
    Frontiers in Pharmacology, 2021-07-02;12(0):699842.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells
    Applications: ICC, Western Blot
  162. MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling
    Authors: H Nakashima, K Tsujimura, K Irie, T Imamura, CA Trujillo, M Ishizu, M Uesaka, M Pan, H Noguchi, K Okada, K Aoyagi, T Andoh-Noda, H Okano, AR Muotri, K Nakashima
    Cell Reports, 2021-05-18;35(7):109124.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: ICC
  163. G392E neuroserpin causing the dementia FENIB is secreted from cells but is not synaptotoxic
    Authors: T Ingwersen, C Linnenberg, E D'Acunto, S Temori, I Paolucci, D Wasilewski, B Mohammadi, J Kirchmair, RC Glen, E Miranda, M Glatzel, G Galliciott
    Scientific Reports, 2021-04-22;11(1):8766.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  164. Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality
    Authors: MT Dang, MV Gonzalez, KS Gaonkar, KS Rathi, P Young, S Arif, L Zhai, Z Alam, S Devalaraja, TKJ To, IW Folkert, P Raman, JL Rokita, D Martinez, JN Taroni, JA Shapiro, CS Greene, C Savonen, F Mafra, H Hakonarson, T Curran, M Haldar
    Cell Reports, 2021-03-30;34(13):108917.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  165. Chronic exposure to IL-6 induces a desensitized phenotype of the microglia
    Authors: M Recasens, B Almolda, J Pérez-Clau, IL Campbell, B González, B Castellano
    Journal of Neuroinflammation, 2021-01-22;18(1):31.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  166. Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy
    Authors: M Tajan, M Hennequart, EC Cheung, F Zani, AK Hock, N Legrave, ODK Maddocks, RA Ridgway, D Athineos, A Suárez-Bon, RL Ludwig, L Novellasde, N Angelis, VSW Li, G Vlachogian, N Valeri, N Mainolfi, V Suri, A Friedman, M Manfredi, K Blyth, OJ Sansom, KH Vousden
    Nature Communications, 2021-01-14;12(1):366.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  167. Individual-oocyte transcriptomic analysis shows that genotoxic chemotherapy depletes human primordial follicle reserve�in vivo by triggering proapoptotic pathways without growth activation
    Authors: S Titus, KJ Szymanska, B Musul, V Turan, E Taylan, R Garcia-Mil, S Mehta, K Oktay
    Scientific Reports, 2021-01-11;11(1):407.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  168. Acute systemic loss of Mad2 leads to intestinal atrophy in adult mice
    Authors: KM Schukken, Y Zhu, PL Bakker, MH Koster, L Harkema, SA Youssef, A de Bruin, F Foijer
    Scientific Reports, 2021-01-08;11(1):68.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  169. ABL001, a Bispecific Antibody Targeting VEGF and DLL4, with Chemotherapy, Synergistically Inhibits Tumor Progression in Xenograft Models
    Authors: DH Yeom, YS Lee, I Ryu, S Lee, B Sung, HB Lee, D Kim, JH Ahn, E Ha, YS Choi, SH Lee, WK You
    International Journal of Molecular Sciences, 2020-12-29;22(1):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  170. Pantoprazole impairs fracture healing in aged mice
    Authors: MM Menger, P Bremer, C Scheuer, MF Rollmann, BJ Braun, SC Herath, M Orth, T Später, T Pohlemann, MD Menger, T Histing
    Scientific Reports, 2020-12-23;10(1):22376.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  171. Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons
    Authors: Y Arioka, E Shishido, I Kushima, T Suzuki, R Saito, A Aiba, D Mori, N Ozaki
    EBioMedicine, 2020-12-17;63(0):103138.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  172. Naringenin exerts anticancer effects by inducing tumor cell death and inhibiting angiogenesis in malignant melanoma
    Authors: J Choi, DH Lee, H Jang, SY Park, JW Seol
    International Journal of Medical Sciences, 2020-10-18;17(18):3049-3057.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  173. Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon
    Authors: B Di Marco, EE Crouch, B Shah, C Duman, MF Paredes, C Ruiz de Al, EJ Huang, J Alfonso
    Cell Rep, 2020-10-13;33(2):108256.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  174. Effects of the Delta Opioid Receptor Agonist DADLE in a Novel Hypoxia-Reoxygenation Model on Human and Rat-Engineered Heart Tissue: A Pilot Study
    Authors: S Funcke, TR Werner, M Hein, BM Ulmer, A Hansen, T Eschenhage, MN Hirt
    Biomolecules, 2020-09-11;10(9):.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC
  175. Inhibition of DDR1 enhances in vivo chemosensitivity in KRAS-mutant lung adenocarcinoma
    Authors: MJ Nokin, E Darbo, C Travert, B Drogat, A Lacouture, S San José, N Cabrera, B Turcq, V Prouzet-Ma, M Falcone, A Villanueva, H Wang, M Herfs, M Mosteiro, PA Jänne, JL Pujol, A Maraver, M Barbacid, E Nadal, D Santamaría, C Ambrogio
    JCI Insight, 2020-08-06;5(15):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  176. Characterization of a new small-molecule inhibitor of HDAC6 in glioblastoma
    Authors: J Auzmendi-I, A Saenz-Anto, I Mikelez-Al, E Carrasco-G, M Tellaetxe-, CH Lawrie, N Sampron, AL Cortajaren, A Matheu
    Cell Death Dis, 2020-06-02;11(6):417.
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC
  177. Targeting Actomyosin Contractility Suppresses Malignant Phenotypes of Acute Myeloid Leukemia Cells
    Authors: F Chang, SJ Kong, L Wang, BK Choi, H Lee, C Kim, JM Kim, K Park
    Int J Mol Sci, 2020-05-14;21(10):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  178. Erbb4 Is Required for Cerebellar Developmentand Malignant Phenotype of Medulloblastoma
    Authors: J Aldaregia, P Errarte, A Olazagoiti, M Gimeno, JJ Uriz, TR Gershon, I Garcia, A Matheu
    Cancers (Basel), 2020-04-17;12(4):.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  179. Ex Vivo MRI Analytical Methods and Brain Pathology in Preterm Lambs Treated with Postnatal Dexamethasone �
    Authors: NJ Yates, KW Feindel, A Mehnert, R Beare, S Quick, D Blache, JJ Pillow, RW Hunt
    Brain Sci, 2020-04-03;10(4):.
    Species: Lamb
    Sample Types: Whole Tissue
    Applications: IHC
  180. Hypoxia-induced complement dysregulation is associated with microvascular impairments in mouse tracheal transplants
    Authors: MA Khan, T Shamma, S Kazmi, A Altuhami, HA Ahmed, AM Assiri, DC Broering
    J Transl Med, 2020-03-31;18(1):147.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  181. Embryonic Barcoding of Equipotent Mammary Progenitors Functionally Identifies Breast Cancer Drivers
    Authors: Z Ying, S Beronja
    Cell Stem Cell, 2020-02-13;0(0):.
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  182. SOX9 promotes tumor progression through the axis BMI1-p21CIP
    Authors: P Aldaz, M Otaegi-Uga, A Saenz-Anto, M Garcia-Pug, M Moreno-Val, JM Flores, D Gerovska, MJ Arauzo-Bra, N Samprón, A Matheu, E Carrasco-G
    Sci Rep, 2020-01-15;10(1):357.
    Species: Human
    Sample Types: Whole Cells
    Applications: IF
  183. Neurovascular effects of umbilical cord blood-derived stem cells in growth-restricted newborn lambs : UCBCs for perinatal brain injury
    Authors: A Malhotra, M Castillo-M, BJ Allison, AE Sutherland, I Nitsos, Y Pham, CA McDonald, MC Fahey, GR Polglase, G Jenkin, SL Miller
    Stem Cell Res Ther, 2020-01-08;11(1):17.
  184. Expression of apoptotic and proliferation factors in gastric mucosa of patients with systemic sclerosis correlates with form of the disease
    Authors: K Boric, S Mardesic, D Martinovic, M Radic, I Tadin Hadj, K Vukojevic, I Kosovic, I Solic, S Zekic Toma, M Saraga-Bab
    Sci Rep, 2019-12-05;9(1):18461.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  185. NF-kappaB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells
    Authors: LG Jones, A Vaida, LM Thompson, FI Ikuomola, JH Caamaño, MD Burkitt, F Miyajima, JM Williams, BJ Campbell, DM Pritchard, CA Duckworth
    Cell Death Dis, 2019-11-26;10(12):896.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  186. Severe head dysgenesis resulting from imbalance between anterior and posterior ontogenetic programs
    Authors: E Grall, V Gourain, A Naïr, E Martin, MC Birling, JN Freund, I Duluc
    Cell Death Dis, 2019-10-24;10(11):812.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  187. Kidins220/ARMS controls astrocyte calcium signaling and neuron-astrocyte communication
    Authors: F Jaudon, M Chiacchiar, M Albini, S Ferroni, F Benfenati, F Cesca
    Cell Death Differ., 2019-10-17;27(5):1505-1519.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: ICC
  188. Aberrant DNA Polymerase Beta Enhances H. pylori Infection Induced Genomic Instability and Gastric Carcinogenesis in Mice
    Authors: S Zhao, M Thakur, AW Klattenhof, D Kidane
    Cancers (Basel), 2019-06-18;11(6):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  189. TBC1D24 regulates axonal outgrowth and membrane trafficking at the growth cone in rodent and human neurons
    Authors: D Aprile, F Fruscione, S Baldassari, M Fadda, D Ferrante, A Falace, E Buhler, J Sartorelli, A Represa, P Baldelli, F Benfenati, F Zara, A Fassio
    Cell Death Differ., 2019-03-11;0(0):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: ICC
  190. SH3BP4 Regulates Intestinal Stem Cells and Tumorigenesis by Modulating ?-Catenin Nuclear Localization
    Authors: P Antas, L Novellasde, A Kucharska, I Massie, J Carvalho, D Oukrif, E Nye, M Novelli, VSW Li
    Cell Rep, 2019-02-26;26(9):2266-2273.e4.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  191. Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells
    Authors: BA Brown, GM Connolly, CEJ Mill, H Williams, GD Angelini, JL Johnson, SJ George
    Aging Cell, 2018-12-12;0(0):e12844.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  192. Loss of Ccbe1 affects cardiac-specification and cardiomyocyte differentiation in mouse embryonic stem cells
    Authors: O Bover, T Justo, PNG Pereira, J Facucho-Ol, JM Inácio, JS Ramalho, IJ Domian, JA Belo
    PLoS ONE, 2018-10-03;13(10):e0205108.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  193. Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation
    Authors: RK Zwick, MC Rudolph, BA Shook, B Holtrup, E Roth, V Lei, A Van Keymeu, V Seewaldt, S Kwei, J Wysolmersk, MS Rodeheffer, V Horsley
    Nat Commun, 2018-09-04;9(1):3592.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  194. BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer
    Authors: M Ouarné, C Bouvard, G Boneva, C Mallet, J Ribeiro, A Desroches-, E Soleilhac, E Tillet, O Peyruchaud, S Bailly
    J. Exp. Clin. Cancer Res., 2018-08-30;37(1):209.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  195. An Adult Zebrafish Model Reveals that Mucormycosis Induces Apoptosis of Infected Macrophages
    Authors: A López-Muño, FE Nicolás, D García-Mor, AB Pérez-Oliv, MI Navarro-Me, MA Hernández-, A Herrera-Es, S Torres-Mar, RM Ruiz-Vázqu, V Garre, V Mulero
    Sci Rep, 2018-08-24;8(1):12802.
    Species: Zebrafish
    Sample Types: Whole Tissue
    Applications: IHC-P
  196. The protective effects of total paeony glycoside on ischemia/reperfusion injury in H9C2 cells via inhibition of the PI3K/Akt signaling pathway
    Authors: P Shen, J Chen, M Pan
    Mol Med Rep, 2018-07-30;18(3):3332-3340.
    Species: Rat
    Sample Types: Cell Lysates
    Applications: Western Blot
  197. Epidermal-specific deletion of TC-PTP promotes UVB-induced epidermal cell survival through the regulation of Flk-1/JNK signaling
    Authors: M Baek, M Kim, JS Lim, LD Morales, J Hernandez, S Mummidi, S Williams-B, IS Jang, AT Tsin, DJ Kim
    Cell Death Dis, 2018-06-28;9(7):730.
    Species: Human
    Sample Types: Whole Cells
  198. Intracellular attenuation of BMP signaling via CKIP-1/Smurf1 is essential during neural crest induction
    Authors: ML Piacentino, ME Bronner
    PLoS Biol., 2018-06-27;16(6):e2004425.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: IHC-P
  199. PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification
    Authors: I Cohen, D Zhao, C Bar, VJ Valdes, KL Dauber-Dec, MB Nguyen, M Nakayama, M Rendl, WA Bickmore, H Koseki, D Zheng, E Ezhkova
    Cell Stem Cell, 2018-05-03;22(5):726-739.e7.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  200. Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids
    Authors: P Srikanth, VN Lagomarsin, CR Muratore, SC Ryu, A He, WM Taylor, C Zhou, M Arellano, TL Young-Pear
    Transl Psychiatry, 2018-04-12;8(1):77.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  201. Synapsin I and Synapsin II regulate neurogenesis in the dentate gyrus of adult mice
    Authors: R Barbieri, A Contestabi, MG Ciardo, N Forte, A Marte, P Baldelli, F Benfenati, F Onofri
    Oncotarget, 2018-04-10;9(27):18760-18774.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  202. The kallikrein-Kinin system modulates the progression of colorectal liver metastases in a mouse model
    Authors: PLN da Costa, D Wynne, T Fifis, L Nguyen, M Perini, C Christophi
    BMC Cancer, 2018-04-04;18(1):382.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  203. Tracking cellular and molecular changes in a species-specific manner during experimental tumor progression in vivo
    Authors: E Indersie, KB Hooks, C Capdeviell, M Fabre, N Dugot-Sena, A Desplat, S Lepreux, A Merched, CF Grosset, M Hagedorn
    Oncotarget, 2018-03-01;9(22):16149-16162.
    Species: Human
    Sample Types: Complex Sample Type
    Applications: IHC
  204. A motif within the armadillo repeat of Parkinson's-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway
    Authors: N Antoniou, D Vlachakis, A Memou, E Leandrou, PE Valkimadi, K Melachroin, DB Re, S Przedborsk, WT Dauer, L Stefanis, HJ Rideout
    Sci Rep, 2018-02-22;8(1):3455.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  205. Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres
    Authors: JM Povedano, P Martinez, R Serrano, Á Tejera, G Gómez-Lópe, M Bobadilla, JM Flores, F Bosch, MA Blasco
    Elife, 2018-01-30;7(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  206. Intermittent, low dose carbon monoxide exposure enhances survival and dopaminergic differentiation of human neural stem cells
    Authors: N Dreyer-And, AS Almeida, P Jensen, M Kamand, J Okarmus, T Rosenberg, SD Friis, A Martínez S, M Blaabjerg, BW Kristensen, T Skrydstrup, JB Gramsberge, HLA Vieira, M Meyer
    PLoS ONE, 2018-01-16;13(1):e0191207.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  207. KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS
    Authors: C Ambrogio, J Köhler, ZW Zhou, H Wang, R Paranal, J Li, M Capelletti, C Caffarra, S Li, Q Lv, S Gondi, JC Hunter, J Lu, R Chiarle, D Santamaría, KD Westover, PA Jänne
    Cell, 2018-01-11;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  208. Aneurysm Severity is Increased by Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression
    Authors: CA Lyon, H Williams, R Bianco, SJ Simmonds, BA Brown, KS Wadey, FCT Smith, JL Johnson, SJ George
    Sci Rep, 2017-12-11;7(1):17342.
    Species: Human, Mouse
    Sample Types: Whole Tissue
    Applications: ICC, IHC
  209. Caspase-3/-7-Specific Metabolic Precursor for Bioorthogonal Tracking of Tumor Apoptosis
    Authors: MK Shim, HY Yoon, S Lee, MK Jo, J Park, JH Kim, SY Jeong, IC Kwon, K Kim
    Sci Rep, 2017-11-30;7(1):16635.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  210. The Process of Engraftment of Myogenic Cells in Skeletal Muscles of Primates: Understanding Clinical Observations and Setting Directions in Cell Transplantation Research
    Authors: D Skuk, JP Tremblay
    Cell Transplant, 2017-11-01;26(11):1763-1779.
    Species: Primate
    Sample Types: Whole Tissue
    Applications: IHC
  211. Oxidative damage and impairment of protein quality control systems in keratinocytes exposed to a volatile organic compounds cocktail
    Authors: M Dezest, M Le Bechec, L Chavatte, V Desauziers, B Chaput, JL Grolleau, P Descargues, C Nizard, S Schnebert, S Lacombe, AL Bulteau
    Sci Rep, 2017-09-06;7(1):10707.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC, IHC-P
  212. Glycogen synthase kinase-3 inhibition sensitizes human induced pluripotent stem cells to thiol-containing antioxidants induced apoptosis
    Authors: C Tu, R Xu, M Koleti, J Zoldan
    Stem Cell Res, 2017-07-22;23(0):182-187.
    Species: Human
    Sample Types: Whole Cells
    Applications: Functional Assay
  213. New tumor suppressor microRNAs target glypican-3 in human liver cancer
    Authors: F Cartier, E Indersie, S Lesjean, J Charpentie, KB Hooks, A Ghousein, A Desplat, N Dugot-Sena, V Trézéguet, F Sagliocco, M Hagedorn, CF Grosset
    Oncotarget, 2017-06-20;0(0):.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: IHC
  214. Loss of the Wnt receptor Frizzled7 in the gastric epithelium is deleterious and triggers rapid repopulation in vivo
    Authors: DJ Flanagan, N Barker, C Nowell, H Clevers, M Ernst, TJ Phesse, E Vincan
    Dis Model Mech, 2017-06-09;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  215. VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis
    Authors: JY Jang, SY Choi, I Park, DY Park, K Choe, P Kim, YK Kim, BJ Lee, M Hirashima, Y Kubota, JW Park, SY Cheng, A Nagy, YJ Park, K Alitalo, M Shong, GY Koh
    EMBO Mol Med, 2017-06-01;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  216. A role for core planar polarity proteins in cell contact-mediated orientation of planar cell division across the mammalian embryonic skin
    Authors: F Oozeer, LL Yates, C Dean, CJ Formstone
    Sci Rep, 2017-05-12;7(1):1880.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  217. Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium.
    Authors: Lynne A Murray, Rebecca Dunmore, Ana Camelo, Carla A Da Silva, Malin J Gustavsso, David M Habiel, Tillie L Hackett, Cory M Hogaboam, Matthew A Sleeman, Darryl A Knight
    Respiratory Research, 2017-05-03;0(0):1465-993X.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  218. Constitutive WNT/CTNNB1 activation triggers spermatogonial stem cell proliferation and germ cell depletion
    Authors: AA Chassot, M Le Rolle, M Jourden, MM Taketo, NB Ghyselinck, MC Chaboissie
    Dev. Biol., 2017-04-26;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  219. Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth
    Authors: JC Klein, K Moses, G Zelinskyy, S Sody, J Buer, S Lang, I Helfrich, U Dittmer, CJ Kirschning, S Brandau
    Nat Commun, 2017-03-16;8(0):14600.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  220. The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries
    Authors: S Grasso, J Chapelle, V Salemme, S Aramu, I Russo, N Vitale, L Verdun di, K Dallaglio, I Castellano, A Amici, G Centonze, N Sharma, S Lunardi, S Cabodi, F Cavallo, A Lamolinara, L Stramucci, E Moiso, P Provero, A Albini, A Sapino, J Staaf, PP Di Fiore, G Bertalot, S Pece, D Tosoni, S Confalonie, M Iezzi, P Di Stefano, E Turco, P Defilippi
    Nat Commun, 2017-03-16;8(0):14797.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  221. Low Dose Radiation Causes Skin Cancer In Mice And Has A Differential Effect on Distinct Epidermal Stem Cells
    Authors: T Revenco, G Lapouge, V Moers, S Broh‚e, PA Sotiropoul
    Stem Cells, 2017-02-01;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  222. Combined effects of atorvastatin and aspirin on growth and apoptosis in human prostate cancer cells
    Authors: Y He, H Huang, C Farischon, D Li, Z Du, K Zhang, X Zheng, S Goodin
    Oncol. Rep, 2017-01-04;37(2):953-960.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  223. Bifidobacterium breve reduces apoptotic epithelial cell shedding in an exopolysaccharide and MyD88-dependent manner
    Authors: KR Hughes, LC Harnisch, C Alcon-Gine, S Mitra, CJ Wright, J Ketskemety, D van Sinder, AJ Watson, LJ Hall
    Open Biol, 2017-01-01;7(1):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  224. Autophagy deficient keratinocytes display increased DNA damage, senescence and aberrant lipid composition after oxidative stress in vitro and in vivo
    Redox Biol, 2016-12-18;11(0):219-230.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  225. cMyc Regulates the Size of the Premigratory Neural Crest Stem Cell Pool
    Cell Rep, 2016-12-06;17(10):2648-2659.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IHC
  226. Activation of FADD-Dependent Neuronal Death Pathways as a Predictor of Pathogenicity for LRRK2 Mutations
    PLoS ONE, 2016-11-10;11(11):e0166053.
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC
  227. Proliferation, differentiation and migration of SCA1(-)/CD31(-) cardiac side population cells in vitro and in vivo
    Authors: Simon X Liang
    Int. J. Cardiol., 2016-11-09;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  228. Axonal Cleaved Caspase-3 Regulates Axon Targeting and Morphogenesis in the Developing Auditory Brainstem
    Authors: Karina S Cramer
    Front Neural Circuits, 2016-10-24;10(0):84.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: IHC
  229. CDK7 and miR-210 Co-regulate Cell-Cycle Progression of Neural Progenitors in the Developing Neocortex
    Stem Cell Reports, 2016-07-12;7(1):69-79.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  230. Amplification of R-spondin1 signaling induces granulosa cell fate defects and cancers in mouse adult ovary
    Authors: M-C De Cian
    Oncogene, 2016-06-06;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  231. Defining the cellular lineage hierarchy in the interfollicular epidermis of adult skin
    Nat. Cell Biol., 2016-05-16;18(6):619-31.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  232. Mutations in Cockayne Syndrome-Associated Genes (Csa and Csb) Predispose to Cisplatin-Induced Hearing Loss in Mice
    J Neurosci, 2016-04-27;36(17):4758-70.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  233. Brinp1 (-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density
    Authors: SR Berkowicz, TJ Featherby, Z Qu, A Giousoh, NA Borg, JI Heng, JC Whisstock, PI Bird
    Mol Autism, 2016-03-31;7(0):22.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  234. Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue.
    Authors: Jacob F, Yonis A, Cuello F, Luther P, Schulze T, Eder A, Streichert T, Mannhardt I, Hirt M, Schaaf S, Stenzig J, Force T, Eschenhagen T, Hansen A
    PLoS ONE, 2016-02-03;11(2):e0145937.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC-P
  235. Cord blood mononuclear cells prevent neuronal apoptosis in response to perinatal asphyxia in the newborn lamb
    Authors: JD Aridas, CA McDonald, MC Paton, T Yawno, AE Sutherland, I Nitsos, Y Pham, M Ditchfield, MC Fahey, F Wong, A Malhotra, M Castillo-M, K Bhakoo, EM Wallace, G Jenkin, SL Miller
    J. Physiol. (Lond.), 2015-12-14;594(5):1421-35.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  236. Apoptosis-Related Factors in the Luteal Phase of the Domestic Cat and Their Involvement in the Persistence of Corpora Lutea in Lynx.
    Authors: Amelkina O, Zschockelt L, Painer J, Serra R, Villaespesa F, Braun B, Jewgenow K
    PLoS ONE, 2015-11-24;10(11):e0143414.
    Species: Feline
    Sample Types: Whole Tissue
    Applications: IHC-P
  237. Attenuation of Cerebral Ischemic Injury in Smad1 Deficient Mice.
    Authors: Wong J, Chen L, Huang Y, Sehba F, Friedel R, Zou H
    PLoS ONE, 2015-08-28;10(8):e0136967.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  238. An essential role for Ink4 and Cip/Kip cell-cycle inhibitors in preventing replicative stress.
    Authors: Quereda V, Porlan E, Canamero M, Dubus P, Malumbres M
    Cell Death Differ, 2015-08-21;23(3):430-41.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  239. The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice.
    Authors: Douglas T, Champagne C, Morizot A, Lapointe J, Saleh M
    J Immunol, 2015-07-27;195(5):2365-73.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  240. BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus.
    Authors: Levet S, Ouarne M, Ciais D, Coutton C, Subileau M, Mallet C, Ricard N, Bidart M, Debillon T, Faravelli F, Rooryck C, Feige J, Tillet E, Bailly S
    Proc Natl Acad Sci U S A, 2015-06-08;112(25):E3207-15.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  241. Exacerbated experimental colitis in TNFAIP8-deficient mice.
    Authors: Sun H, Lou Y, Porturas T, Morrissey S, Luo G, Qi J, Ruan Q, Shi S, Chen Y
    J Immunol, 2015-05-06;194(12):5736-42.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  242. Deficiency for the cysteine protease cathepsin L impairs Myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer.
    Authors: Brindle N, Joyce J, Rostker F, Lawlor E, Swigart-Brown L, Evan G, Hanahan D, Shchors K
    PLoS ONE, 2015-04-30;10(4):e0120348.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  243. Pulmonary alveolar macrophages contribute to the premetastatic niche by suppressing antitumor T cell responses in the lungs.
    Authors: Sharma S, Chintala N, Vadrevu S, Patel J, Karbowniczek M, Markiewski M
    J Immunol, 2015-04-24;194(11):5529-38.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  244. Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response.
    Authors: Sesen J, Dahan P, Scotland S, Saland E, Dang V, Lemarie A, Tyler B, Brem H, Toulas C, Cohen-Jonathan Moyal E, Sarry J, Skuli N
    PLoS ONE, 2015-04-13;10(4):e0123721.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  245. Hepatocyte-specific deletion of ARNT (aryl hydrocarbon Receptor Nuclear Translocator) results in altered fibrotic gene expression in the thioacetamide model of liver injury.
    Authors: Scott C, Cha K, Rao R, Liddle C, George J, Gunton J
    PLoS ONE, 2015-03-26;10(3):e0121650.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  246. TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus.
    Authors: Matsuda T, Murao N, Katano Y, Juliandi B, Kohyama J, Akira S, Kawai T, Nakashima K
    Nat Commun, 2015-03-09;6(0):6514.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  247. Preclinical studies identify non-apoptotic low-level caspase-3 as therapeutic target in pemphigus vulgaris.
    Authors: Luyet C, Schulze K, Sayar B, Howald D, Muller E, Galichet A
    PLoS ONE, 2015-03-06;10(3):e0119809.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  248. Interactions of highly and low virulent Flavobacterium columnare isolates with gill tissue in carp and rainbow trout.
    Authors: Declercq, Annelies, Chiers, Koen, Van den Broeck, Wim, Dewulf, Jeroen, Eeckhaut, Venessa, Cornelissen, Maria, Bossier, Peter, Haesebrouck, Freddy, Decostere, Annemie
    Vet Res, 2015-03-06;46(0):25.
    Species: Fish - Cyprinus carpio (Carp), Fish - Oncorhynchus mykiss (Rainbow Trout)
    Sample Types: Whole Tissue
    Applications: IHC-P
  249. Alpha-enolase is upregulated on the cell surface and responds to plasminogen activation in mice expressing a 133p53alpha mimic.
    Authors: Sawhney S, Hood K, Shaw A, Braithwaite A, Stubbs R, Hung N, Royds J, Slatter T
    PLoS ONE, 2015-02-02;10(2):e0116270.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  250. Interfering with stem cell-specific gatekeeper functions controls tumour initiation and malignant progression of skin tumours.
    Authors: Petersson, Monika, Reuter, Karen, Brylka, Heike, Kraus, Andreas, Schettina, Peter, Niemann, Catherin
    Nat Commun, 2015-01-22;6(0):5874.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  251. Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration.
    Authors: Moyon S, Dubessy A, Aigrot M, Trotter M, Huang J, Dauphinot L, Potier M, Kerninon C, Melik Parsadaniantz S, Franklin R, Lubetzki C
    J Neurosci, 2015-01-07;35(1):4-20.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  252. Antigen dependently activated cluster of differentiation 8-positive T cells cause perforin-mediated neurotoxicity in experimental stroke.
    Authors: Mracsko E, Liesz A, Stojanovic A, Lou W, Osswald M, Zhou W, Karcher S, Winkler F, Martin-Villalba A, Cerwenka A, Veltkamp R
    J Neurosci, 2014-12-10;34(50):16784-95.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  253. Epidermal growth factor attenuates tubular necrosis following mercuric chloride damage by regeneration of indigenous, not bone marrow-derived cells.
    Authors: Yen T, Alison M, Goodlad R, Otto W, Jeffery R, Cook H, Wright N, Poulsom R
    J Cell Mol Med, 2014-11-11;19(2):463-73.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  254. Differential sensitivity of prefrontal cortex and hippocampus to alcohol-induced toxicity.
    Authors: Fowler, Anna-Kat, Thompson, Jeremy, Chen, Lixia, Dagda, Marisela, Dertien, Janet, Dossou, Katina S, Moaddel, Ruin, Bergeson, Susan E, Kruman, Inna I
    PLoS ONE, 2014-09-04;9(9):e106945.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  255. Erythropoietin suppresses the activation of pro-apoptotic genes in head and neck squamous cell carcinoma xenografts exposed to surgical trauma.
    Authors: Lindgren G, Ekblad L, Vallon-Christersson J, Kjellen E, Gebre-Medhin M, Wennerberg J
    BMC Cancer, 2014-09-02;14(0):648.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  256. Short term morphine exposure in vitro alters proliferation and differentiation of neural progenitor cells and promotes apoptosis via mu receptors.
    Authors: Willner D, Cohen-Yeshurun A, Avidan A, Ozersky V, Shohami E, Leker R
    PLoS ONE, 2014-07-29;9(7):e103043.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IHC
  257. Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity.
    Authors: Park D, Lee J, Park I, Choi D, Lee S, Song S, Hwang Y, Hong K, Nakaoka Y, Makinen T, Kim P, Alitalo K, Hong Y, Koh G
    J Clin Invest, 2014-07-25;124(9):3960-74.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  258. LMO4 functions as a negative regulator of sensory organ formation in the mammalian cochlea.
    Authors: Deng M, Luo X, Pan L, Yang H, Xie X, Liang G, Huang L, Hu F, Kiernan A, Gan L
    J Neurosci, 2014-07-23;34(30):10072-7.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  259. mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress.
    Authors: Grahammer F, Haenisch N, Steinhardt F, Sander L, Roerden M, Arnold F, Cordts T, Wanner N, Reichardt W, Kerjaschki D, Ruegg M, Hall M, Moulin P, Busch H, Boerries M, Walz G, Artunc F, Huber T
    Proc Natl Acad Sci U S A, 2014-06-23;111(27):E2817-26.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  260. Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-beta.
    Authors: Wiener Z, Band A, Kallio P, Hogstrom J, Hyvonen V, Kaijalainen S, Ritvos O, Haglund C, Kruuna O, Robine S, Louvard D, Ben-Neriah Y, Alitalo K
    Proc Natl Acad Sci U S A, 2014-05-13;111(21):E2229-36.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: Flow Cytometry, IHC
  261. Influence of oxygen tension on dopaminergic differentiation of human fetal stem cells of midbrain and forebrain origin.
    Authors: Krabbe C, Bak S, Jensen P, von Linstow C, Martinez Serrano A, Hansen C, Meyer M
    PLoS ONE, 2014-05-02;9(5):e96465.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  262. Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function.
    Authors: Kumar L, Chou J, Yee C, Borzutzky A, Vollmann E, von Andrian U, Park S, Hollander G, Manis J, Poliani P, Geha R
    J Exp Med, 2014-04-21;211(5):929-42.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  263. Essential role for the TRF2 telomere protein in adult skin homeostasis.
    Authors: Martinez P, Ferrara-Romeo I, Flores J, Blasco M
    Aging Cell, 2014-04-14;13(4):656-68.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  264. Pseudomonas aeruginosa-induced apoptosis in airway epithelial cells is mediated by gap junctional communication in a JNK-dependent manner.
    Authors: Losa D, Kohler T, Bellec J, Dudez T, Crespin S, Bacchetta M, Boulanger P, Hong S, Morel S, Nguyen T, van Delden C, Chanson M
    J Immunol, 2014-04-14;192(10):4804-12.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  265. Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers.
    Authors: Edlund R, Ohyama T, Kantarci H, Riley B, Groves A
    Dev Biol, 2014-03-18;390(1):1-13.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  266. Germline quality control: eEF2K stands guard to eliminate defective oocytes.
    Authors: Chu H, Liao Y, Novak J, Hu Z, Merkin J, Shymkiv Y, Braeckman B, Dorovkov M, Nguyen A, Clifford P, Nagele R, Harrison D, Ellis R, Ryazanov A
    Dev Cell, 2014-02-27;28(5):561-72.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  267. Mechanism of cystogenesis in nephrotic kidneys: a histopathological study.
    Authors: Saraga M, Vukojevic K, Krzelj V, Puretic Z, Bocina I, Durdov M, Weber S, Dworniczak B, Ljubanovic D, Saraga-Babic M
    BMC Nephrol, 2014-01-08;15(0):3.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  268. Endoplasmic reticulum stress in amelogenesis imperfecta and phenotypic rescue using 4-phenylbutyrate.
    Authors: Brookes, Steven J, Barron, Martin J, Boot-Handford, Ray, Kirkham, Jennifer, Dixon, Michael
    Hum Mol Genet, 2013-12-20;23(9):2468-80.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  269. Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling.
    Authors: Fan J, Ponferrada V, Sato T, Vemaraju S, Fruttiger M, Gerhardt H, Ferrara N, Lang R
    Development, 2013-12-18;141(2):448-59.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  270. The extracellular matrix glycoprotein tenascin-R regulates neurogenesis during development and in the adult dentate gyrus of mice.
    Authors: Xu J, Xiao M, Jakovcevski I, Sivukhina E, Hargus G, Cui Y, Irintchev A, Schachner M, Bernreuther C
    J Cell Sci, 2013-12-11;127(0):641-52.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  271. Caspase 3 involves in neuroplasticity, microglial activation and neurogenesis in the mice hippocampus after intracerebral injection of kainic acid.
    Authors: Tzeng, Tsai-Ten, Tsay, Huey-Jen, Chang, Luping, Hsu, Chia-Lin, Lai, Tzu-Hsua, Huang, Fong-Lee, Shiao, Young-Ji
    J Biomed Sci, 2013-12-06;20(0):90.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  272. Biphasic influence of Miz1 on neural crest development by regulating cell survival and apical adhesion complex formation in the developing neural tube.
    Authors: Kerosuo L, Bronner M
    Mol Biol Cell, 2013-12-04;25(3):347-55.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: IHC
  273. The temporal and spatial profiles of cell loss following experimental spinal cord injury: effect of antioxidant therapy on cell death and functional recovery.
    Authors: Ling, Xiang, Bao, Feng, Qian, Hao, Liu, Danxia
    BMC Neurosci, 2013-11-18;14(0):146.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC
  274. Requirements for Aurora-A in tissue regeneration and tumor development in adult mammals.
    Authors: Perez de Castro I, Aguirre-Portoles C, Fernandez-Miranda G, Canamero M, Cowley D, Van Dyke T, Malumbres M
    Cancer Res, 2013-11-15;73(22):6804-15.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  275. Epigenetics and cell death: DNA hypermethylation in programmed retinal cell death.
    Authors: Wahlin, Karl J, Enke, Raymond, Fuller, John A, Kalesnykas, Giedrius, Zack, Donald J, Merbs, Shannath
    PLoS ONE, 2013-11-11;8(11):e79140.
    Species: Chicken, Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  276. A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis.
    Authors: Olive V, Sabio E, Bennett M, De Jong C, Biton A, McGann J, Greaney S, Sodir N, Zhou A, Balakrishnan A, Foth M, Luftig M, Goga A, Speed T, Xuan Z, Evan G, Wan Y, Minella A, He L
    Elife, 2013-10-15;2(0):e00822.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  277. Dysregulated STAT1-SOCS1 control of JAK2 promotes mammary luminal progenitor cell survival and drives ERalpha(+) tumorigenesis.
    Authors: Chan S, Rickert C, Vermi W, Sheehan K, Arthur C, Allen J, White J, Archambault J, Lonardi S, McDevitt T, Bhattacharya D, Lorenzi M, Allred D, Schreiber R
    Cell Death Differ, 2013-09-13;21(2):234-46.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  278. Increased chondrocyte apoptosis is associated with progression of osteoarthritis in spontaneous Guinea pig models of the disease.
    Authors: Zamli Z, Adams M, Tarlton J, Sharif M
    Int J Mol Sci, 2013-08-29;14(9):17729-43.
    Species: Guinea Pig
    Sample Types: Whole Tissue
    Applications: IHC
  279. Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages.
    Authors: Stott, Simon R, Metzakopian, Emmanoui, Lin, Wei, Kaestner, Klaus H, Hen, Rene, Ang, Siew-Lan
    J Neurosci, 2013-05-01;33(18):8022-34.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  280. Diet-induced obesity exacerbates auditory degeneration via hypoxia, inflammation, and apoptosis signaling pathways in CD/1 mice.
    Authors: Hwang J, Hsu C, Yu W, Liu T, Yang W
    PLoS ONE, 2013-04-26;8(4):e60730.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  281. Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-kappaB and Src protein kinase signaling pathways.
    Authors: Shakibaei M, Mobasheri A, Lueders C, Busch F, Shayan P, Goel A
    PLoS ONE, 2013-02-22;8(2):e57218.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  282. Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesis.
    Cell Death Differ., 2012-05-04;19(11):1761-8.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  283. Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy.
    Authors: McIntyre A, Patiar S, Wigfield S
    Clin. Cancer Res., 2012-04-12;18(11):3100-11.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  284. An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration.
    Authors: Chen T, Heller E, Beronja S, Oshimori N, Stokes N, Fuchs E
    Nature, 2012-04-04;485(7396):104-8.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  285. Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation.
    Authors: Fuxe J, Tabruyn S, Colton K, Zaid H, Adams A, Baluk P, Lashnits E, Morisada T, Le T, O'Brien S, Epstein DM, Koh GY, McDonald DM
    Am. J. Pathol., 2011-05-06;178(6):2897-909.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  286. Robo1 regulates semaphorin signaling to guide the migration of cortical interneurons through the ventral forebrain.
    Authors: Hernandez-Miranda LR, Cariboni A, Faux C, Ruhrberg C, Cho JH, Cloutier JF, Eickholt BJ, Parnavelas JG, Andrews WD
    J. Neurosci., 2011-04-20;31(16):6174-87.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  287. Two hypomorphic alleles of mouse Ass1 as a new animal model of citrullinemia type I and other hyperammonemic syndromes.
    Authors: Perez CJ, Jaubert J, Guenet JL, Barnhart KF, Ross-Inta CM, Quintanilla VC, Aubin I, Brandon JL, Otto NW, DiGiovanni J, Gimenez-Conti I, Giulivi C, Kusewitt DF, Conti CJ, Benavides F
    Am. J. Pathol., 2010-08-19;177(4):1958-68.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  288. Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death.
    Authors: Sotiropoulou PA, Candi A, Mascre G, De Clercq S, Youssef KK, Lapouge G, Dahl E, Semeraro C, Denecker G, Marine JC, Blanpain C
    Nat. Cell Biol., 2010-05-16;12(6):572-82.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry, ICC
  289. MicroRNA-183 family members regulate sensorineural fates in the inner ear.
    Authors: Li H, Kloosterman W, Fekete DM
    J. Neurosci., 2010-03-03;30(9):3254-63.
    Species: Zebrafish
    Sample Types: Whole Tissue
    Applications: IHC
  290. Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth.
    Authors: Hashizume H, Falcon BL, Kuroda T, Baluk P, Coxon A, Yu D, Bready JV, Oliner JD, McDonald DM
    Cancer Res., 2010-03-02;70(6):2213-23.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  291. ALK1 signaling regulates early postnatal lymphatic vessel development.
    Authors: Niessen K, Zhang G, Ridgway JB, Chen H, Yan M
    Blood, 2009-11-10;115(8):1654-61.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  292. Mitogen-activated protein kinase-signaling regulates the ability of Muller glia to proliferate and protect retinal neurons against excitotoxicity.
    Authors: Fischer AJ, Scott MA, Ritchey ER, Sherwood P
    Glia, 2009-11-01;57(14):1538-52.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  293. Role of neurosteroids in regulating cell death and proliferation in the late gestation fetal brain.
    Authors: Yawno T, Hirst JJ, Castillo-Melendez M, Walker DW
    Neuroscience, 2009-07-08;163(3):838-47.
    Species: Ovine
    Sample Types: Whole Tissue
    Applications: IHC-P
  294. Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease.
    Authors: Borchers MT, Wesselkamper SC, Curull V, Ramirez-Sarmiento A, Sanchez-Font A, Garcia-Aymerich J, Coronell C, Lloreta J, Agusti AG, Gea J, Howington JA, Reed MF, Starnes SL, Harris NL, Vitucci M, Eppert BL, Motz GT, Fogel K, McGraw DW, Tichelaar JW, Orozco-Levi M
    J. Clin. Invest., 2009-02-09;119(3):636-49.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  295. Repeated ethanol exposure during late gestation alters the maturation and innate immune status of the ovine fetal lung.
    Authors: Sozo F, O'Day L, Maritz G, Kenna K, Stacy V, Brew N, Walker D, Bocking A, Brien J, Harding R
    Am. J. Physiol. Lung Cell Mol. Physiol., 2008-12-26;296(3):L510-8.
    Species: Ovine
    Sample Types: Whole Tissue
    Applications: IHC-P
  296. A functional interaction between Irx and Meis patterns the anterior hindbrain and activates krox20 expression in rhombomere 3.
    Authors: Stedman A, Lecaudey V, Havis E, Anselme I, Wassef M, Gilardi-Hebenstreit P, Schneider-Maunoury S
    Dev. Biol., 2008-12-25;327(2):566-77.
    Species: Zebrafish
    Sample Types: Whole Tissue
    Applications: IHC
  297. Cisplatin-resistant neuroblastoma cells express enhanced levels of epidermal growth factor receptor (EGFR) and are sensitive to treatment with EGFR-specific toxins.
    Authors: Michaelis M, Bliss J, Arnold SC, Hinsch N, Rothweiler F, Deubzer HE, Witt O, Langer K, Doerr HW, Wels WS, Cinatl J
    Clin. Cancer Res., 2008-10-15;14(20):6531-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  298. The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis.
    Authors: Heckman CA, Holopainen T, Wirzenius M, Keskitalo S, Jeltsch M, Yla-Herttuala S, Wedge SR, Jurgensmeier JM, Alitalo K
    Cancer Res., 2008-06-15;68(12):4754-62.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  299. Cystic fibrosis transmembrane conductance regulator controls lung proteasomal degradation and nuclear factor-kappaB activity in conditions of oxidative stress.
    Authors: Boncoeur E, Roque T, Bonvin E, Saint-Criq V, Bonora M, Clement A, Tabary O, Henrion-Caude A, Jacquot J
    Am. J. Pathol., 2008-03-27;172(5):1184-94.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  300. Telomerase reverses epidermal hair follicle stem cell defects and loss of long-term survival associated with critically short telomeres.
    Authors: Siegl-Cachedenier I, Flores I, Klatt P, Blasco MA
    J. Cell Biol., 2007-10-22;179(2):277-90.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  301. Cytotoxic action of phorbol esters on human pancreatic cancer cells.
    Authors: Bond JA, Gescher AJ, Verschoyle RD, Lemoine NR, Errington R, Wiltshire M, Smith PJ, Wynford-Thomas D
    Int. J. Cancer, 2007-10-01;121(7):1445-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  302. Multiple neurotoxic stresses converge on MDMX proteolysis to cause neuronal apoptosis.
    Authors: Benosman S, Gross I, Clarke N, Jochemsen AG, Okamoto K, Loeffler JP, Gaiddon C
    Cell Death Differ., 2007-09-07;14(12):2047-57.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  303. Gam1-associated alterations of drug responsiveness through activation of apoptosis.
    Authors: Wu F, Chiocca S, Beck WT, Mo YY
    Mol. Cancer Ther., 2007-06-01;6(6):1823-30.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  304. Cytochemical and ultrastructural study of anoikis and secondary necrosis in enterocytes detached in vivo.
    Authors: do Vale A, Costa-Ramos C, Silva DS, Macedo PM, Fernandes R, Sampaio P, Dos Santos NM, Silva MT
    Apoptosis, 2007-06-01;12(6):1069-83.
    Species: Fish
    Sample Types: Whole Tissue
    Applications: IHC-P
  305. Inhibition of neurosteroid synthesis increases asphyxia-induced brain injury in the late gestation fetal sheep.
    Authors: Yawno T, Yan EB, Walker DW, Hirst JJ
    Neuroscience, 2007-04-20;146(4):1726-33.
    Species: Ovine
    Sample Types: Whole Tissue
    Applications: IHC-P
  306. Protein C is an autocrine growth factor for human skin keratinocytes.
    Authors: Xue M, Campbell D, Jackson CJ
    J. Biol. Chem., 2007-02-09;282(18):13610-6.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  307. Loss of vascular endothelial growth factor expression reduces vascularization, but not growth, of tumors lacking the Von Hippel-Lindau tumor suppressor gene.
    Authors: Blouw B, Haase VH, Song H, Bergers G, Johnson RS
    Oncogene, 2007-02-05;26(31):4531-40.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  308. Involvement of the Edar signaling in the control of hair follicle involution (catagen).
    Authors: Fessing MY, Sharova TY, Sharov AA, Atoyan R, Botchkarev VA
    Am. J. Pathol., 2006-12-01;169(6):2075-84.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  309. Invasive trophoblasts stimulate vascular smooth muscle cell apoptosis by a fas ligand-dependent mechanism.
    Authors: Harris LK, Keogh RJ, Wareing M, Baker PN, Cartwright JE, Aplin JD, Whitley GS
    Am. J. Pathol., 2006-11-01;169(5):1863-74.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  310. Canonical notch signaling functions as a commitment switch in the epidermal lineage.
    Authors: Blanpain C, Lowry WE, Pasolli HA, Fuchs E
    Genes Dev., 2006-11-01;20(21):3022-35.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  311. Tendon-muscle crosstalk controls muscle bellies morphogenesis, which is mediated by cell death and retinoic acid signaling.
    Authors: Rodriguez-Guzman M, Montero JA, Santesteban E, Ganan Y, Macias D, Hurle JM
    Dev. Biol., 2006-09-26;302(1):267-80.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: IHC
  312. Evolution of the androgen receptor pathway during progression of prostate cancer.
    Authors: Hendriksen PJ, Dits NF, Kokame K, Veldhoven A, van Weerden WM, Bangma CH, Trapman J, Jenster G
    Cancer Res., 2006-05-15;66(10):5012-20.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  313. Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice.
    Authors: Jacomy H, Fragoso G, Almazan G, Mushynski WE, Talbot PJ
    Virology, 2006-03-09;349(2):335-46.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  314. Mechanisms of apoptosis after ischemia and reperfusion: role of the renin-angiotensin system.
    Authors: Kossmehl P, Kurth E, Faramarzi S, Habighorst B, Shakibaei M, Wehland M, Kreutz R, Infanger M, J Danser AH, Grosse J, Paul M, Grimm D
    Apoptosis, 2006-03-01;11(3):347-58.
    Species: Porcine
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  315. Wnt signals mediate a fate decision between otic placode and epidermis.
    Authors: Ohyama T, Mohamed OA, Taketo MM, Dufort D, Groves AK
    Development, 2006-02-01;133(5):865-75.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  316. Expression and functional analysis of Bax inhibitor-1 in human breast cancer cells.
    Authors: Grzmil M, Kaulfuss S, Thelen P, Hemmerlein B, Schweyer S, Obenauer S, Kang TW, Burfeind P
    J. Pathol., 2006-02-01;208(3):340-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  317. Helicobacter felis and Helicobacter bizzozeronii induce gastric parietal cell loss in Mongolian gerbils.
    Authors: De Bock M, Decostere A, Hellemans A, Haesebrouck F, Ducatelle R
    Microbes Infect., 2005-10-11;8(2):503-10.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  318. Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation.
    Authors: Gueders MM, Balbin M, Rocks N, Foidart JM, Gosset P, Louis R, Shapiro S, Lopez-Otin C, Noel A, Cataldo DD
    J. Immunol., 2005-08-15;175(4):2589-97.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  319. Higher resistance of porcine trigeminal ganglion neurons towards pseudorabies virus-induced cell death compared with other porcine cell types in vitro.
    Authors: Geenen K, Favoreel HW, Nauwynck HJ
    J. Gen. Virol., 2005-05-01;86(0):1251-60.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: ICC
  320. Effects of systemically administered NT-3 on sensory neuron loss and nestin expression following axotomy.
    Authors: Kuo LT, Simpson A, Schanzer A, Tse J, An SF, Scaravilli F, Groves MJ
    J. Comp. Neurol., 2005-02-21;482(4):320-32.
    Species: Rat
    Sample Types: Whole Cells
    Applications: ICC
  321. Apoptosis and active caspase-3 expression in human granulosa cells.
    Authors: Glamoclija V, Vilovic K, Saraga-Babic M, Baranovic A, Sapunar D
    Fertil. Steril., 2005-02-01;83(2):426-31.
    Species: Human
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC-P
  322. The pseudorabies virus US3 protein kinase possesses anti-apoptotic activity that protects cells from apoptosis during infection and after treatment with sorbitol or staurosporine.
    Authors: Geenen K, Favoreel HW, Olsen L, Enquist LW, Nauwynck HJ
    Virology, 2005-01-05;331(1):144-50.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: ICC
  323. Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block.
    Authors: Salomonsson S, Sonesson SE, Ottosson L, Muhallab S, Olsson T, Sunnerhagen M, Kuchroo VK, Thoren P, Herlenius E, Wahren-Herlenius M
    J. Exp. Med., 2005-01-03;201(1):11-7.
    Species: Rat
    Sample Types: Whole Cells
    Applications: ICC
  324. Lactate dehydrogenase-elevating virus induces apoptosis in cultured macrophages and in spinal cords of C58 mice coincident with onset of murine amyotrophic lateral sclerosis.
    Authors: Zitterkopf NL, McNeal DW, Eyster KM, Bradley DS, Cafruny WA
    Virus Res., 2004-11-01;106(1):35-42.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC-Fr
  325. Analysis of central regulatory pathways in p53-deficient primary cultures of malignant fibrous histiocytoma exposed to ifosfamide.
    Authors: Schlott T, Taubert H, Fayyazi A, Schweyer S, Bartel F, Korabiowska M, Brinck U
    Anticancer Res., 2004-11-01;24(6):3819-29.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  326. Evidence of caspase-3 activation in hyposmotic stress-induced necrosis.
    Authors: Niquet J, Allen SG, Baldwin RA, Wasterlain CG
    Neurosci. Lett., 2004-02-19;356(3):225-7.
    Species: Rat
    Sample Types: Whole Cells
    Applications: ICC
  327. Blockade of the type I IGF receptor expression in human prostate cancer cells inhibits proliferation and invasion, up-regulates IGF binding protein-3, and suppresses MMP-2 expression.
    Authors: Grzmil M, Hemmerlein B, Thelen P, Schweyer S, Burfeind P
    J. Pathol., 2004-01-01;202(1):50-9.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: ICC
  328. Early events in the anoikis program occur in the absence of caspase activation.
    Authors: Wang P, Valentijn AJ, Gilmore AP, Streuli CH
    J. Biol. Chem., 2003-03-05;278(22):19917-25.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  329. Kidins220/ARMS modulates brain morphology and anxiety-like traits in adult mice
    Authors: Amanda Almacellas-Barbanoj, Martina Albini, Annyesha Satapathy, Fanny Jaudon, Caterina Michetti, Alicja Krawczun-Rygmaczewska et al.
    Cell Death Discovery
  330. Murine scald models characterize the role of neutrophils and neutrophil extracellular traps in severe burns
    Authors: Julia Elrod, Moritz Lenz, Antonia Kiwit, Lina Armbrust, Lavinia Schönfeld, Konrad Reinshagen et al.
    Frontiers in Immunology
  331. YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development
    Authors: Filipa Neto, Alexandra Klaus-Bergmann, Yu Ting Ong, Silvanus Alt, Anne-Clémence Vion, Anna Szymborska et al.
    eLife
  332. Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice
    Authors: Chunxing Yang, Tao Qiao, Jia Yu, Hongyan Wang, Yansu Guo, Johnny Salameh et al.
    PLOS ONE
  333. Hexane Extracts of Calophyllum brasiliense Inhibit the Development of Gastric Preneoplasia in Helicobacter felis Infected INS-Gas Mice
    Authors: Larissa M. S. Lemos, Fabio Miyajima, Geovane R. C. Castilho, Domingos Tabajara O. Martins, D. Mark Pritchard, Michael D. Burkitt
    Frontiers in Pharmacology
  334. Olig3 regulates early cerebellar development
    Authors: Elijah D Lowenstein, Aleksandra Rusanova, Jonas Stelzer, Marc Hernaiz-Llorens, Adrian E Schroer, Ekaterina Epifanova et al.
    eLife
  335. Hepatocyte nuclear factor 1 beta controls nephron tubular development
    Authors: Filippo Massa, Serge Garbay, Raymonde Bouvier, Yoshinobu Sugitani, Tetsuo Noda, Marie-Claire Gubler et al.
    Development
  336. Elk3 is essential for the progression from progenitor to definitive neural crest cell
    Authors: Crystal D. Rogers, Jacquelyn L. Phillips, Marianne E. Bronner
    Developmental Biology
  337. Kidins220/ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems
    Authors: F Cesca, A Yabe, B Spencer-Dene, J Scholz-Starke, L Medrihan, C H Maden et al.
    Cell Death & Differentiation
  338. Nuclear NAD+-biosynthetic enzyme NMNAT1 facilitates development and early survival of retinal neurons
    Authors: David Sokolov, Emily R Sechrest, Yekai Wang, Connor Nevin, Jianhai Du, Saravanan Kolandaivelu
    eLife
  339. Rapid Disruption of Axon–Glial Integrity in Response to Mild Cerebral Hypoperfusion
    Authors: Michell Mario Reimer, Jamie McQueen, Luke Searcy, Gillian Scullion, Barbara Zonta, Anne Desmazieres et al.
    The Journal of Neuroscience
  340. Control of neural crest multipotency by Wnt signaling and the Lin28/let-7 axis
    Authors: Debadrita Bhattacharya, Megan Rothstein, Ana Paula Azambuja, Marcos Simoes-Costa
    eLife
  341. A multiomics analysis of direct interkingdom dynamics between influenza A virus and Streptococcus pneumoniae uncovers host-independent changes to bacterial virulence fitness
    Authors: Maryann P. Platt, Yi-Han Lin, Trevor Penix, Rosana Wiscovitch-Russo, Isha Vashee, Chris A. Mares et al.
    PLOS Pathogens
  342. Post-transcriptional tuning of FGF signaling mediates neural crest induction
    Authors: J Copeland, M Simoes-Cos
    Proceedings of the National Academy of Sciences of the United States of America, 2020-12-21;117(52):33305-33316.
  343. Temporal changes in plasma membrane lipid content induce endocytosis to regulate developmental epithelial-to-mesenchymal transition
    Authors: Michael L. Piacentino, Erica J. Hutchins, Cecelia J. Andrews, Marianne E. Bronner
    Proceedings of the National Academy of Sciences
  344. Bone mesenchymal stem cells-derived miR-223-3p-containing exosomes ameliorate lipopolysaccharide-induced acute uterine injury via interacting with endothelial progenitor cells
    Authors: Yana Liu, Shihong Zhang, Zhiwei Xue, Xiaoxia Zhou, Lin Tong, Jiachen Liao et al.
    Bioengineered
  345. Tetraspanin CD9 Limits Mucosal Healing in Experimental Colitis
    Authors: María Laura Saiz, Danay Cibrian, Marta Ramírez-Huesca, Daniel Torralba, Olga Moreno-Gonzalo, Francisco Sánchez-Madrid
    Frontiers in Immunology
  346. IGF-1 and PDGF-bb Suppress IL-1 beta -Induced Cartilage Degradation through Down-Regulation of NF-kappa B Signaling: Involvement of Src/PI-3K/AKT Pathway
    Authors: Azadeh Montaseri, Franziska Busch, Ali Mobasheri, Constanze Buhrmann, Constance Aldinger, Jafar Soleimani Rad et al.
    PLoS ONE
  347. Sex-dependent effect of a low neurosteroid environment and intrauterine growth restriction on fetal guinea pig brain development.
    Authors: Kelleher MA, Palliser HK, Walker DW, Hirst JJ.
    J Endocrinol.
  348. Genipin protects against H2O2-induced oxidative damage in�retinal pigment epithelial cells by promoting Nrf2 signaling
    Authors: Hailan Zhao, Ruiqing Wang, Mingxia Ye, Lan Zhang
    International Journal of Molecular Medicine
  349. Influence mechanism of miRNA‑144 on proliferation and apoptosis of osteosarcoma cells
    Authors: Xu Zhang, Zhengwei Li, Wei Ji, Xilong Chen, Qiang Gao, Dajin Li et al.
    Oncology Letters
  350. Neuropathology as a consequence of neonatal ventilation in premature growth-restricted lambs
    Authors: Atul Malhotra, Margie Castillo-Melendez, Beth J. Allison, Amy E. Sutherland, Ilias Nitsos, Yen Pham et al.
    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
  351. Brain Injury in Canine Models of Cardiac Surgery
    Authors: Mary E. Blue, Mary Ann Wilson, Claude A. Beaty, Timothy J. George, George J. Arnaoutakis, Kara A. Haggerty et al.
    Journal of Neuropathology & Experimental Neurology
  352. Histone deacetylase 3 (HDAC3) plays an important role in retinal ganglion cell death after acute optic nerve injury
    Authors: Heather M Schmitt, Heather R Pelzel, Cassandra L Schlamp, Robert W Nickells
    Molecular Neurodegeneration
  353. Spatial morphological and molecular differences within solid tumors may contribute to the failure of vascular disruptive agent treatments
    Authors: Linh Nguyen, Theodora Fifis, Caterina Malcontenti-Wilson, Lie Sam Chan, Patricia Nunes Luiza Costa, Mehrdad Nikfarjam et al.
    BMC Cancer
  354. Stromal impact on tumor growth and lymphangiogenesis in human carcinoma xenografts
    Authors: Elin Hadler-Olsen, Hilde Ljones Wetting, Oddveig Rikardsen, Sonja E. Steigen, Premasany Kanapathippillai, Reidar Grénman et al.
    Virchows Archiv
  355. Anti-TNF antibodies do not induce the apoptosis of lamina propria mononuclear cells in uninflamed intestinal tissue in patients with Crohn’s disease
    Authors: Piotr Eder, Liliana Lykowska-Szuber, Iwona Krela-Kazmierczak, Kamila Stawczyk-Eder, Karolina Sterzynska, Katarzyna Iwanik et al.
    Folia Histochemica et Cytobiologica
  356. Potent Inhibitory Effect of δ-Tocopherol on Prostate Cancer Cells Cultured in Vitro and Grown As Xenograft Tumors in Vivo
    Authors: Huarong Huang, Yan He, Xiao-Xing Cui, Susan Goodin, Hong Wang, Zhi Yun Du et al.
    Journal of Agricultural and Food Chemistry
  357. Kidins220/ARMS is an essential modulator of cardiovascular and nervous system development
    Authors: F Cesca, A Yabe, B Spencer-Dene, A Arrigoni, M Al-Qatari, D Henderson et al.
    Cell Death & Disease
  358. Histone demethylase KDM4B regulates otic vesicle invagination via epigenetic control of Dlx3 expression
    Authors: Uribe RA, Buzzi AL, Bronner ME et al.
    J Cell Biol
  359. Neuronal Loss in the Rostral Ventromedial Medulla in a Rat Model of Neuropathic Pain
    Authors: Mai Lan Leong, Ming Gu, Rebecca Speltz Speltz-Paiz, Eleanor I. Stahura, Neli Mottey, Clifford J. Steer et al.
    The Journal of Neuroscience
  360. Impairment of Pol &beta-related DNA Base-excision Repair Leads to Ovarian Aging in Mice
    Authors: K Hua, L Wang, J Sun, N Zhou, Y Zhang, F Ji, L Jing, Y Yang, W Xia, Z Hu, F Pan, X Chen, B Yao, Z Guo
    Aging (Albany NY), 2020-11-20;12(0):.
  361. IL-1 drives breast cancer growth and bone metastasis in vivo
    Authors: Ingunn Holen, Diane V. Lefley, Sheila E. Francis, Sarah Rennicks, Steven Bradbury, Robert E. Coleman et al.
    Oncotarget
  362. EMC3 regulates mesenchymal cell survival via control of the mitotic spindle assembly
    Authors: Tang X, Wei W, Snowball JM et al.
    iScience
  363. Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin
    Authors: Seo Rin Kim, Kai Jiang, Mikolaj Ogrodnik, Xiaojun Chen, Xiang-Yang Zhu, Hannah Lohmeier et al.
    Translational Research
  364. Knockdown of p66Shc Alters Lineage-Associated Transcription Factor Expression in Mouse Blastocysts
    Authors: Nicole A. Edwards, Andrew J. Watson, Dean H. Betts
    Stem Cells and Development
  365. Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout
    Authors: H Ehlken, S Krishna-Subramanian, L Ochoa-Callejero, V Kondylis, N E Nadi, B K Straub et al.
    Cell Death & Differentiation
  366. Cadherin-11 Is Required for Neural Crest Specification and Survival
    Authors: Subrajaa Manohar, Alberto Camacho-Magallanes, Camilo Echeverria, Crystal D. Rogers
    Frontiers in Physiology
  367. Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1
    Authors: Xiaocheng Zhao, Pavel Nedvetsky, Fabio Stanchi, Anne-Clemence Vion, Oliver Popp, Kerstin Zühlke et al.
    eLife
  368. Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum
    Authors: Kuijpers M, Kochlamazashvili G, Stumpf A et al.
    Neuron
  369. Gfi1 Loss Protects against Two Models of Induced Diabetes
    Authors: Tiziana Napolitano, Fabio Avolio, Serena Silvano, Sara Forcisi, Anja Pfeifer, Andhira Vieira et al.
    Cells
  370. IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide
    Authors: Roger Ramcharan, Tamara Aleksic, Wilfride Petnga Kamdoum, Shan Gao, Sophia X. Pfister, Jordan Tanner et al.
    Oncotarget
  371. DDIT3 (CHOP) contributes to retinal ganglion cell somal loss but not axonal degeneration in DBA/2J mice
    Authors: Olivia J. Marola, Stephanie B. Syc-Mazurek, Richard T. Libby
    Cell Death Discovery
  372. The immunoexpression of androgen receptor, estrogen receptors alpha and beta, vanilloid type 1 receptor and cytochrome p450 aromatase in rats testis chronically treated with letrozole, an aromatase inhibitor
    Authors: Anna Pilutin, Kamila Misiakiewicz-Has, Agnieszka Kolasa, Irena Baranowska-Bosiacka, Mariola Marchlewicz, Barbara Wiszniewska
    Folia Histochemica et Cytobiologica
  373. Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa
    Authors: Stamatia Papoutsopoulou, Joseph Tang, Ahmed H. Elramli, Jonathan M. Williams, Nitika Gupta, Felix I. Ikuomola et al.
    American Journal of Physiology-Gastrointestinal and Liver Physiology
  374. Prenatal ethanol exposure induces susceptibility to premature ovarian insufficiency
    Authors: Yuan Ni, Dan Xu, Feng Lv, Yang Wan, Guanlan Fan, Wen Zou et al.
    Journal of Endocrinology
  375. Neuroprotective effects of fatty acid amide hydrolase catabolic enzyme inhibition in a HIV-1 Tat model of neuroAIDS
    Authors: Douglas J. Hermes, Changqing Xu, Justin L. Poklis, Micah J. Niphakis, Benjamin F. Cravatt, Ken Mackie et al.
    Neuropharmacology
  376. Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development
    Authors: Alejandra González-Loyola, Gonzalo Fernández-Miranda, Marianna Trakala, David Partida, Kumiko Samejima, Hiromi Ogawa et al.
    Molecular and Cellular Biology
  377. EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation
    Authors: Hanane Lanaya, Anuradha Natarajan, Karin Komposch, Liang Li, Nicole Amberg, Lei Chen et al.
    Nature Cell Biology
  378. Motor uncoordination and neuropathology in a transgenic mouse model of Machado–Joseph disease lacking intranuclear inclusions and ataxin-3 cleavage products
    Authors: Anabela Silva-Fernandes, Maria do Carmo Costa, Sara Duarte-Silva, Pedro Oliveira, Claudia M. Botelho, Luís Martins et al.
    Neurobiology of Disease
  379. The late endosomal adaptor molecule p14 (LAMTOR2) represents a novel regulator of Langerhans cell homeostasis
    Authors: Florian Sparber, Julia M. Scheffler, Nicole Amberg, Christoph H. Tripp, Valeska Heib, Martin Hermann et al.
    Blood
  380. Synergistic cooperation between ABT-263 and MEK1/2 inhibitor: effect on apoptosis and proliferation of acute myeloid leukemia cells
    Authors: Kelly Airiau, Valérie Prouzet-Mauléon, Benoit Rousseau, Arnaud Pigneux, Marie Jeanneteau, Manon Giraudon et al.
    Oncotarget
  381. CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors
    Authors: Roxane Van Heurck, Jérôme Bonnefont, Marta Wojno, Ikuo K. Suzuki, Fausto D. Velez-Bravo, Emir Erkol et al.
    Neuron
  382. Dentate gyrus development requires a cortical hem-derived astrocytic scaffold
    Authors: Alessia Caramello, Christophe Galichet, Karine Rizzoti, Robin Lovell-Badge
    eLife
  383. Age-Dependent Degeneration of Mature Dentate Gyrus Granule Cells Following NMDA Receptor Ablation
    Authors: Yasuhito Watanabe, Michaela K. Müller, Jakob von Engelhardt, Rolf Sprengel, Peter H. Seeburg, Hannah Monyer
    Frontiers in Molecular Neuroscience
  384. Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation
    Authors: Rocío López-Posadas, Christoph Becker, Claudia Günther, Stefan Tenzer, Kerstin Amann, Ulrike Billmeier et al.
    Journal of Clinical Investigation
  385. Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents
    Authors: Anastasia R. Goloudina, Kan Tanoue, Arlette Hammann, Eric Fourmaux, Xavier Le Guezennec, Dmitry V. Bulavin et al.
    Proceedings of the National Academy of Sciences
  386. Retinoic acid temporally orchestrates colonization of the gut by vagal neural crest cells
    Authors: Rosa A. Uribe, Stephanie S. Hong, Marianne E. Bronner
    Developmental Biology
  387. Contrasting effects of an Mdm2 functional polymorphism on tumor phenotypes
    Authors: Guadalupe J. Ortiz, Yanjie Li, Sean M. Post, Vinod Pant, Shunbin Xiong, Connie A. Larsson et al.
    Oncogene
  388. The mouse Foxi3 transcription factor is necessary for the development of posterior placodes
    Authors: Onur Birol, Takahiro Ohyama, Renée K. Edlund, Katerina Drakou, Pantelis Georgiades, Andrew K. Groves
    Developmental Biology
  389. Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside of the crypt base stem cell niche
    Authors: Hayley Davis, Shazia Irshad, Mukesh Bansal, Hannah Rafferty, Tatjana Boitsova, Chiara Bardella et al.
    Nature Medicine

FAQs

  1. What is the genus of rabbit used to produce Human/Mouse Active Caspase-3 Antibody, Catalog # AF835? 

    • The genus is Oryctolagus cuniculus.

  2. Does Human/Mouse Active Caspase-3 antibody, Catalog # AF835, detect cleaved Caspase-3?

    • AF835 can detect active Caspase-3, but it may not be specific for the cleaved from only as it can also detect the full length protein.

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Human/Mouse Active Caspase-3 Antibody
By Anonymous on 07/20/2021
Application: IHC Sample Tested: Kidney tissue Species: Mouse
Immunohistochemistry Human/Mouse Active Caspase-3 Antibody AF835
Human/Mouse Active Caspase-3 Antibody
By Anonymous on 07/09/2021
Application: Immunocytochemistry/Immunofluorescence Sample Tested: Squamous cell carcinoma (OSCC) cells Species: Mouse
Immunocytochemistry/Immunofluorescence Human/Mouse Active Caspase-3 Antibody AF835
Human/Mouse Active Caspase-3 Antibody
By Anonymous on 02/15/2021
Application: IHC Sample Tested: Small intestine Species: Mouse
Immunohistochemistry Human/Mouse Active Caspase-3 Antibody AF835
Human/Mouse Active Caspase-3 Antibody
By Anonymous on 12/22/2017
Application: Immunocytochemistry/Immunofluorescence Sample Tested: Spleen tissue Species: Mouse

Used to check for apoptose of macrophages

Immunocytochemistry/Immunofluorescence Human/Mouse Active Caspase-3 Antibody AF835
Human/Mouse Active Caspase-3 Antibody
By Liz Bishop on 05/17/2017
Application: IHC Sample Tested: Brain (hippocampus) Species: Rat

Active Caspase-3 (red) on fresh frozen, formaldehyde-fixed 10um sections of CA3 region of hippocampus. Good signal, but difficult to image because of high background from NeuN (green).

Immunohistochemistry Human/Mouse Active Caspase-3 Antibody AF835