Home / CCR6 / Human/Mouse CCR6 PE-conjugated Antibody

Human/Mouse CCR6 PE-conjugated Antibody

Catalog #: FAB590P
19 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
FAB590P-025
FAB590P-100
Detection of CCR6 in Mouse Splenocytes by Flow Cytometry.
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Product Details
Citations (19)
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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human/Mouse CCR6 PE-conjugated Antibody Summary

Species Reactivity
Human, Mouse
Specificity
Detects mouse CCR6-transfected rat RBL cells but not the parent cell line or cells transfected with mouse CCR5. Detects human CCR6 in flow cytometry.
Source
Monoclonal Rat IgG2A Clone # 140706
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
RBL-1 rat basophilic leukemia cell line transfected with mouse CCR6
Met1-Met367
Accession # O54689
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Phycoerythrin (Excitation= 488 nm, Emission= 565-605 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of CCR6 antibody in Mouse Splenocytes antibody by Flow Cytometry. View Larger

Detection of CCR6 in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with Rat Anti-Mouse B220/CD45R APC-conjugated Monoclonal Antibody (Catalog # FAB1217A) and either (A) Rat Anti-Human/Mouse CCR6 PE-conjugated Monoclonal Antibody (Catalog # FAB590P) or (B) Rat IgG2APhycoerythrin Isotype Control (Catalog # IC006P). View our protocol for Staining Membrane-associated Proteins.

Flow Cytometry Detection of CCR6 antibody in Human Blood Lymphocytes antibody by Flow Cytometry. View Larger

Detection of CCR6 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human CD19 APC-conjugated Monoclonal Antibody (Catalog # FAB4867A) and either (A) Rat Anti-Human/Mouse CCR6 PE-conjugated Monoclonal Antibody (Catalog # FAB590P) or (B) Rat IgG2APhycoerythrin Isotype Control (Catalog # IC006P). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: CCR6

CCR6 is a seven transmembrane-spanning G protein-coupled receptor that binds the chemokine MIP-3 alpha and mediates the chemoattraction of B and T lymphocytes.

Entrez Gene IDs
1235 (Human); 12458 (Mouse); 308163 (Rat)
Alternate Names
BN-1; CC-CKR-6; CCR6; CCR-6; CD196 antigen; CD196; chemokine (C-C motif) receptor 6; CKRL3; CKR-L3; CKR-L3G-protein coupled receptor 29; CKRL3LARC receptor; CMKBR6; CMKBR6STRL22; DRY6; GPR29; GPR29C-C CKR-6; GPRCY4; GPR-CY4; GPRCY4DRY-6; lymphocyte, 22; STRL22

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Citations for Human/Mouse CCR6 PE-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

19 Citations: Showing 1 - 10
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  1. B cell receptor signaling in germinal centers prolongs survival and primes B cells for selection
    Authors: Spencer T. Chen, Thiago Y. Oliveira, Anna Gazumyan, Melissa Cipolla, Michel C. Nussenzweig
    Immunity
  2. A diminished immune response underlies age-related SARS-CoV-2 pathologies
    Authors: K Oishi, S Horiuchi, J Frere, RE Schwartz, BR tenOever
    Cell Reports, 2022-06-09;39(13):111002.
    Species: Hamster
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  3. Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients
    Authors: M Picard, S Yonekura, K Slowicka, I Petta, C Rauber, B Routy, C Richard, V Iebba, M Tidjani Al, S Becharef, P Ly, E Pizzato, CHK Lehmann, L Amon, C Klein, P Opolon, I Gomperts B, JY Scoazec, A Hollebecqu, D Malka, F Ghiringhel, D Dudziak, G Berx, L Vereecke, G van Loo, G Kroemer, L Zitvogel, MP Roberti
    Cell Death and Differentiation, 2020-12-01;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  4. DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells
    Authors: T Yamamoto, Y Endo, A Onodera, K Hirahara, HK Asou, T Nakajima, T Kanno, Y Ouchi, S Uematsu, H Nishimasu, O Nureki, DJ Tumes, N Shimojo, T Nakayama
    Nat Commun, 2018-10-12;9(1):4231.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  5. The chemokine receptor CCR6 facilitates the onset of mammary neoplasia in the MMTV-PyMT mouse model via recruitment of tumor-promoting macrophages.
    Authors: Boyle S, Faulkner J, McColl S, Kochetkova M
    Mol Cancer, 2015-06-06;14(0):115.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Flow Cytometry
  6. Infection of Female BWF1 Lupus Mice with Malaria Parasite Attenuates B Cell Autoreactivity by Modulating the CXCL12/CXCR4 Axis and Its Downstream Signals PI3K/AKT, NFkappaB and ERK.
    Authors: Badr G, Sayed A, Abdel-Maksoud M, Mohamed A, El-Amir A, Abdel-Ghaffar F, Al-Quraishy S, Mahmoud M
    PLoS ONE, 2015-04-24;10(4):e0125340.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  7. Cryptococcus gattii infection dampens Th1 and Th17 responses by attenuating dendritic cell function and pulmonary chemokine expression in the immunocompetent hosts.
    Authors: Angkasekwinai P, Sringkarin N, Supasorn O, Fungkrajai M, Wang Y, Chayakulkeeree M, Ngamskulrungroj P, Angkasekwinai N, Pattanapanyasat K
    Infect Immun, 2014-06-30;82(9):3880-90.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  8. Differential developmental requirement and peripheral regulation for dermal Vgamma4 and Vgamma6T17 cells in health and inflammation.
    Authors: Cai Y, Xue F, Fleming C, Yang J, Ding C, Ma Y, Liu M, Zhang H, Zheng J, Xiong N, Yan J
    Nat Commun, 2014-06-09;5(0):3986.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  9. Leukocyte attraction by CCL20 and its receptor CCR6 in humans and mice with pneumococcal meningitis.
    Authors: Klein M, Brouwer M, Angele B, Geldhoff M, Marquez G, Varona R, Hacker G, Schmetzer H, Hacker H, Hammerschmidt S, van der Ende A, Pfister H, van de Beek D, Koedel U
    PLoS ONE, 2014-04-03;9(4):e93057.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  10. Liver-resident NK cells confer adaptive immunity in skin-contact inflammation.
    Authors: Peng, Hui, Jiang, Xiaojun, Chen, Yonglin, Sojka, Dorothy, Wei, Haiming, Gao, Xiang, Sun, Rui, Yokoyama, Wayne M, Tian, Zhigang
    J Clin Invest, 2013-03-25;123(4):1444-56.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  11. Notch, Id2, and ROR gamma-t sequentially orchestrate the fetal development of lymphoid tissue inducer cells.
    Authors: Cherrier M, Sawa S, Eberl G
    J. Exp. Med., 2012-03-19;209(4):729-40.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  12. Difference in Th1 and Th17 lymphocyte adhesion to endothelium.
    Authors: Alcaide P, Maganto-Garcia E, Newton G, Travers R, Croce KJ, Bu DX, Luscinskas FW, Lichtman AH
    J. Immunol., 2012-01-04;188(3):1421-30.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  13. CCR7-CCL19/CCL21-regulated dendritic cells are responsible for effectiveness of sublingual vaccination.
    Authors: Song JH, Kim JI, Kwon HJ, Shim DH, Parajuli N, Cuburu N, Czerkinsky C, Kweon MN
    J. Immunol., 2009-06-01;182(11):6851-60.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  14. ATP drives lamina propria T(H)17 cell differentiation.
    Authors: Atarashi K, Nishimura J, Shima T, Umesaki Y, Yamamoto M, Onoue M, Yagita H, Ishii N, Evans R, Honda K, Takeda K
    Nature, 2008-08-20;455(7214):808-12.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  15. Both Th1 and Th17 are immunopathogenic but differ in other key biological activities.
    Authors: Cox CA, Shi G, Yin H, Vistica BP, Wawrousek EF, Chan CC, Gery I
    J. Immunol., 2008-06-01;180(11):7414-22.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  16. Dendritic cells in islets of Langerhans constitutively present beta cell-derived peptides bound to their class II MHC molecules.
    Authors: Calderon B, Suri A, Miller MJ
    Proc. Natl. Acad. Sci. U.S.A., 2008-04-21;105(16):6121-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  17. Chemokine receptor CCR2 but not CCR5 or CCR6 mediates the increase in pulmonary dendritic cells during allergic airway inflammation.
    Authors: Robays LJ, Maes T, Lebecque S, Lira SA, Kuziel WA, Brusselle GG, Joos GF, Vermaelen KV
    J. Immunol., 2007-04-15;178(8):5305-11.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  18. A T-Cell Surface Marker Panel Predicts Murine Acute Graft-Versus-Host Disease
    Authors: Carina A. Bäuerlein, Musga Qureischi, Zeinab Mokhtari, Paula Tabares, Christian Brede, Ana-Laura Jordán Garrote et al.
    Frontiers in Immunology
  19. Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation
    Authors: J Emgård, H Kammoun, B García-Cas, J Chesné, SM Parigi, JM Jacob, HW Cheng, E Evren, S Das, P Czarnewski, N Sleiers, F Melo-Gonza, E Kvedaraite, M Svensson, E Scandella, MR Hepworth, S Huber, B Ludewig, L Peduto, EJ Villablanc, H Veiga-Fern, JP Pereira, RA Flavell, T Willinger
    Immunity, 2018-01-16;48(1):120-132.e8.

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