Human/Mouse CXCL12/SDF-1 Antibody Summary
Lys22-Lys89
Accession # Q6ICW0
Applications
Measured by its ability to neutralize CXCL12/SDF‑1 alpha -induced chemotaxis in the BaF3 mouse pro‑B cell line transfected with human CXCR4. At 111 μg/mL, this antibody will neutralize > 50% of the chemotactic effect due to 2 ng/mL Recombinant Human/Feline/Rhesus Macaque CXCL12/SDF‑1 alpha.
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
Chemotaxis Induced by CXCL12/SDF‑1 alpha and Neutral-ization by Human/Mouse CXCL12/SDF‑1 Antibody. Recombinant Human/Feline/ Rhesus Macaque CXCL12/ SDF-1a (Catalog # 350-NS) chemoattracts the BaF3 mouse pro-B cell line transfected with human CXCR4 in a dose-dependent manner (orange line). Chemotaxis elicited by Recombinant Human/Feline/ Rhesus Macaque CXCL12/ SDF-1a (2 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human/Mouse CXCL12/SDF-1 Monoclonal Antibody (Catalog # MAB310). At 111 µg/mL, this antibody will neutralize > 50% of the chemotactic effect.
Detection of Mouse CXCL12/SDF-1 by In vivo assay Enumeration of bone marrow and blood Lin−/Sca1+ cell numbers following stroke and SDF1-A Antibody.(A) Twenty-four hour post stroke+SDF1-A antibody mice show a marked increase in the number of Lin−/Sca1+ cells present in the bone marrow compared to controls. (B) Twenty-four hour post stroke mice showed a marked decrease in the mobilization of these cells to the blood. * P<0.05. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/24465621), licensed under a CC-BY license. Not internally tested by R&D Systems.
Detection of Mouse CXCL12/SDF-1 by In vivo assay Administration of Lin−/Sca1+ cells post stroke.A. Administration of Lin−/Sca1+ cells post stroke significantly reduced infarct volume at 24 hours post stroke (*P<0.05). B. Administration of the Lin−/Sca1+ cells with an SDF1-A antibody (AB) no longer demonstrates a beneficial reduction in the infarct volume (p = NS). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/24465621), licensed under a CC-BY license. Not internally tested by R&D Systems.
Detection of Mouse CXCL12/SDF-1 by In vivo assay Enumeration of bone marrow and blood Lin−/Sca1+ cell numbers following stroke and SDF1-A Antibody.(A) Twenty-four hour post stroke+SDF1-A antibody mice show a marked increase in the number of Lin−/Sca1+ cells present in the bone marrow compared to controls. (B) Twenty-four hour post stroke mice showed a marked decrease in the mobilization of these cells to the blood. * P<0.05. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/24465621), licensed under a CC-BY license. Not internally tested by R&D Systems.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CXCL12/SDF-1
CXCL12, also known as SDF-1 (stromal cell-derived factor 1) and PBSF (Pre-B cell growth stimulatory factor), is a member of the CXC chemokine superfamily. Two alternatively spliced mRNAs encode CXCL12 alpha (89 aa residues) and CXCL12 beta (93 aa residues) that differ by the addition of 4 amino acids at the carboxy-terminus. Human and mouse CXCL12 are highly conserved. Mature human and mouse CXCL12 differ only by 1 amino acid.
Product Datasheets
Citations for Human/Mouse CXCL12/SDF-1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Secretion of SDF-1alpha by bone marrow-derived stromal cells enhances skin wound healing of C57BL/6 mice exposed to ionizing radiation
Authors: Yannick Landry, Oanh Lê, Kimberly A. Mace, Terry E. Restivo, Christian M. Beauséjour
Journal of Cellular and Molecular Medicine
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CREB1-driven CXCR4hi neutrophils promote skin inflammation in mouse models and human patients
Authors: Chen, J;Bai, Y;Xue, K;Li, Z;Zhu, Z;Li, Q;Yu, C;Li, B;Shen, S;Qiao, P;Li, C;Luo, Y;Qiao, H;Dang, E;Yin, W;Gudjonsson, JE;Wang, G;Shao, S;
Nature communications
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Inflammation triggers ILC3 patrolling of the intestinal barrier
Authors: A Jarade, Z Garcia, S Marie, A Demera, I Prinz, P Bousso, JP Di Santo, N Serafini
Nature Immunology, 2022-08-23;0(0):.
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Aberrant expression of selectin E, CXCL1, and CXCL13 in chronic endometritis
Authors: Kotaro Kitaya, Tadahiro Yasuo
Modern Pathology
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Endothelial‐immune crosstalk contributes to vasculopathy in nonalcoholic fatty liver disease
Authors: Chun‐Yi Ng, Khang Leng Lee, Mark Dhinesh Muthiah, Kan Xing Wu, Florence Wen Jing Chioh, Konstanze Tan et al.
EMBO reports
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Neural cell adhesion molecule is required for ventricular conduction system development
Authors: Camila Delgado, Lei Bu, Jie Zhang, Fang-Yu Liu, Joseph Sall, Feng-Xia Liang et al.
Development
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The Pivotal Role of CXCR7 in Stabilization of the Pulmonary Epithelial Barrier in Acute Pulmonary Inflammation
Authors: Kristian-Christos Ngamsri, Anika Müller, Hans Bösmüller, Jutta Gamper-Tsigaras, Jörg Reutershan, Franziska M. Konrad
The Journal of Immunology
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Stromal-derived MAOB promotes prostate cancer growth and progression
Authors: Pu, T;Wang, J;Wei, J;Zeng, A;Zhang, J;Chen, J;Yin, L;Li, J;Lin, TP;Melamed, J;Corey, E;Gao, AC;Wu, BJ;
Science advances
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal
Authors: Li, Y;Xue, M;Deng, X;Dong, L;Nguyen, LXT;Ren, L;Han, L;Li, C;Xue, J;Zhao, Z;Li, W;Qing, Y;Shen, C;Tan, B;Chen, Z;Leung, K;Wang, K;Swaminathan, S;Li, L;Wunderlich, M;Mulloy, JC;Li, X;Chen, H;Zhang, B;Horne, D;Rosen, ST;Marcucci, G;Xu, M;Li, Z;Wei, M;Tian, J;Shen, B;Su, R;Chen, J;
Cell stem cell
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Interleukin-9 promotes mast cell progenitor proliferation and CCR2-dependent mast cell migration in allergic airway inflammation
Authors: Pajulas, A;Fu, Y;Cheung, CCL;Chu, M;Cannon, A;Alakhras, N;Zhang, J;Ulrich, BJ;Nelson, AS;Zhou, B;Kaplan, MH;
Mucosal immunology
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CD26-negative and CD26-positive tissue-resident fibroblasts contribute to functionally distinct CAF subpopulations in breast cancer
Authors: JM Houthuijze, R de Bruijn, E van der Bu, AP Drenth, E Wientjens, T Filipovic, E Bullock, CS Brambillas, EM Pulver, M Nieuwland, I de Rink, F van Diepen, S Klarenbeek, R Kerkhoven, VG Brunton, CLGJ Scheele, MC Boelens, J Jonkers
Nature Communications, 2023-01-12;14(1):183.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Tumor-infiltrated activated B cells suppress liver metastasis of colorectal cancers
Authors: Y Xu, Z Wei, M Feng, D Zhu, S Mei, Z Wu, Q Feng, W Chang, M Ji, C Liu, Y Zhu, L Shen, F Yang, Y Chen, Y Feng, J Xu, D Zhu
Cell Reports, 2022-08-30;40(9):111295.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Engagement of the CXCL12-CXCR4 Axis in the Interaction of Endothelial Progenitor Cell and Smooth Muscle Cell to Promote Phenotype Control and Guard Vascular Homeostasis
Authors: SF Mause, E Ritzel, A Deck, F Vogt, EA Liehn
International Journal of Molecular Sciences, 2022-01-14;23(2):.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Combination of Fish Oil and Selenium Enhances Anticancer Efficacy and Targets Multiple Signaling Pathways in Anti-VEGF Agent Treated-TNBC Tumor-Bearing Mice
Authors: CH Guo, S Hsia, CH Chung, YC Lin, MY Shih, PC Chen, GW Hsu, CT Fan, CL Peng
Marine Drugs, 2021-03-29;19(4):.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
Plasma cell dynamics in the bone marrow niche
Authors: Z Benet, Z Jing, DR Fooksman
Cell Reports, 2021-02-09;34(6):108733.
Species: Mouse
Sample Types: In Vivo, Whole Cells
Applications: ELISA Capture, Neutralization -
Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling
Authors: J Zheng, D Qu, C Wang, L Ding, W Zhou
BMC Pregnancy Childbirth, 2020-02-10;20(1):87.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Reciprocal signaling and direct physical interactions between fibroblasts and breast cancer cells in a 3D environment
Authors: DJ Wessels, N Pradhan, YN Park, MA Klepitsch, DF Lusche, KJ Daniels, KD Conway, ER Voss, SV Hegde, TP Conway, DR Soll
PLoS ONE, 2019-06-24;14(6):e0218854.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Periarteriolar Glioblastoma Stem Cell Niches Express Bone Marrow Hematopoietic Stem Cell Niche Proteins
Authors: VVV Hira, JR Wormer, H Kakar, B Breznik, B van der Sw, R Hulsbos, W Tigchelaar, Z Tonar, M Khurshed, RJ Molenaar, CJF Van Noorde
J. Histochem. Cytochem., 2018-01-03;0(0):2215541774917.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Indian Hedgehog Suppresses a Stromal Cell-Driven Intestinal Immune Response
Authors: BF Westendorp, NVJA Büller, ON Karpus, WA van Dop, J Koster, R Versteeg, PJ Koelink, CY Snel, S Meisner, JJTH Roelofs, A Uhmann, E Ver Loren, J Heijmans, H Hahn, V Muncan, ME Wildenberg, GR van den Br
Cell Mol Gastroenterol Hepatol, 2017-09-05;5(1):67-82.e1.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Stromal Cell-Derived Factor 1 Mediates Immune Cell Attraction upon Urinary Tract Infection
Authors: B Isaacson, T Hadad, A Glasner, C Gur, Z Granot, G Bachrach, O Mandelboim
Cell Rep, 2017-07-05;20(1):40-47.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis
Authors: XW Chen, TJ Yu, J Zhang, Y Li, HL Chen, GF Yang, W Yu, YZ Liu, XX Liu, CF Duan, HL Tang, M Qiu, CL Wang, H Zheng, J Yue, AM Guo, J Yang
Oncogene, 2017-05-08;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Functional Assay -
Physiologically activated mammary fibroblasts promote postpartum mammary cancer
Authors: Q Guo, J Minnier, J Burchard, K Chiotti, P Spellman, P Schedin
JCI Insight, 2017-03-23;2(6):e89206.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Cathepsin K cleavage of SDF-1? inhibits its chemotactic activity towards glioblastoma stem-like cells
Authors: Vashendriya V V Hira
Biochim. Biophys. Acta, 2016-12-28;0(0):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Intrafibrillar silicified collagen scaffold modulates monocyte to promote cell homing, angiogenesis and bone regeneration
Authors: Ji-Hua Chen
Biomaterials, 2016-10-31;113(0):203-216.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Natural nitration of CXCL12 reduces its signaling capacity and chemotactic activity in vitro and abrogates intra-articular lymphocyte recruitment in vivo
Authors: R Janssens, A Mortier, D Boff, V Vanheule, M Gouwy, C Franck, O Larsen, MM Rosenkilde, J Van Damme, FA Amaral, MM Teixeira, S Struyf, P Proost
Oncotarget, 2016-09-20;7(38):62439-62459.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: ELISA Development (Capture) -
Hepatic carcinoma-associated fibroblasts enhance immune suppression by facilitating the generation of myeloid-derived suppressor cells
Oncogene, 2016-09-05;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
CXCR4+CD45- cells are niche forming for osteoclastogenesis via the SDF-1, CXCL7, and CX3CL1 signaling pathways in bone marrow
Authors: Yoh Goto
Stem Cells, 2016-07-08;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Peritoneal Dissemination Requires an Sp1-Dependent CXCR4/CXCL12 Signaling Axis and Extracellular Matrix-Directed Spheroid Formation.
Authors: Kasagi Y, Harada Y, Morodomi Y, Iwai T, Saito S, Yoshida K, Oki E, Saeki H, Ohgaki K, Sugiyama M, Onimaru M, Maehara Y, Yonemitsu Y
Cancer Res, 2016-01-07;76(2):347-57.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
Lipopolysaccharide Promotes Choroidal Neovascularization by Up-Regulation of CXCR4 and CXCR7 Expression in Choroid Endothelial Cell.
Authors: Feng Y, Guo H, Yuan F, Shen M
PLoS ONE, 2015-08-19;10(8):e0136175.
Species: Rat
Sample Types: In Vivo
Applications: Neutralization -
Mesenchymal Stem Cells Ameliorate Atherosclerotic Lesions via Restoring Endothelial Function.
Authors: Lin Y, Yet S, Hsu Y, Wang G, Hung S
Stem Cells Transl Med, 2014-12-10;4(1):44-55.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow.
Authors: Beck T, Gomes A, Cyster J, Pereira J
J Exp Med, 2014-11-17;211(13):2567-81.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
Vitamin D promotes vascular regeneration.
Authors: Wong M, Leisegang M, Kruse C, Vogel J, Schurmann C, Dehne N, Weigert A, Herrmann E, Brune B, Shah A, Steinhilber D, Offermanns S, Carmeliet G, Badenhoop K, Schroder K, Brandes R
Circulation, 2014-07-11;130(12):976-86.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Platelet expression of stromal cell-derived factor-1 is associated with the degree of valvular aortic stenosis.
Authors: Wurster T, Tegtmeyer R, Borst O, Rath D, Geisler T, Gawaz M, Bigalke B
PLoS ONE, 2014-05-16;9(5):e97405.
Species: Human
Sample Types: Whole Cells
Applications: Functional Assay -
An important role of the SDF-1/CXCR4 axis in chronic skin inflammation.
Authors: Zgraggen, Silvana, Huggenberger, Reto, Kerl, Katrin, Detmar, Michael
PLoS ONE, 2014-04-02;9(4):e93665.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs.
Authors: Fleige H, Ravens S, Moschovakis G, Bolter J, Willenzon S, Sutter G, Haussler S, Kalinke U, Prinz I, Forster R
J Exp Med, 2014-03-24;211(4):643-51.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
SDF1-a facilitates Lin-/Sca1+ cell homing following murine experimental cerebral ischemia.
Authors: Mocco J, Afzal A, Ansari S, Wolfe A, Caldwell K, Connolly E, Scott E
PLoS ONE, 2014-01-20;9(1):e85615.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
Hematopoietic stem cell cytokines and fibroblast growth factor-2 stimulate human endothelial cell-pericyte tube co-assembly in 3D fibrin matrices under serum-free defined conditions.
Authors: Smith A, Bowers S, Stratman A, Davis G
PLoS ONE, 2013-12-31;8(12):e85147.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Inhibition of CXCR4-CXCL12 chemotaxis in melanoma by AMD11070.
Authors: O'Boyle, G, Swidenbank, I, Marshall, H, Barker, C E, Armstrong, J, White, S A, Fricker, S P, Plummer, R, Wright, M, Lovat, P E
Br J Cancer, 2013-03-28;108(8):1634-40.
Species: Human
Sample Types: Whole Cells
Applications: IHC -
CXCL12-CXCR4 signaling is required for the maintenance of mouse spermatogonial stem cells.
Authors: Yang, Qi-En, Kim, Dongwon, Kaucher, Amy, Oatley, Melissa, Oatley, Jon M
J Cell Sci, 2012-12-13;126(0):1009-20.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Stromal cell-derived factor-1 is essential for photoreceptor cell protection in retinal detachment.
Authors: Otsuka H, Arimura N, Sonoda S
Am. J. Pathol., 2010-10-01;177(5):2268-77.
Species: Rat
Sample Types: In Vivo
Applications: Neutralization -
CXCR4 and CXCR7 regulate angiogenesis and CT26.WT tumor growth independent from SDF-1.
Authors: Kollmar O, Rupertus K, Scheuer C, Nickels RM, Haberl GC, Tilton B, Menger MD, Schilling MK
Int. J. Cancer, 2010-03-15;126(6):1302-15.
Species: Mouse
Sample Types: In Vivo, Whole Cells, Whole Tissue
Applications: IHC-P, Neutralization -
Stimulation of chondrocyte hypertrophy by chemokine stromal cell-derived factor 1 in the chondro-osseous junction during endochondral bone formation.
Authors: Wei L, Kanbe K, Lee M, Wei X, Pei M, Sun X, Terek R, Chen Q
Dev. Biol., 2010-03-04;341(1):236-45.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
CXCL12 is essential for migration of activated Langerhans cells from epidermis to dermis.
Authors: Ouwehand K, Santegoets SJ, Bruynzeel DP, Scheper RJ, de Gruijl TD, Gibbs S
Eur. J. Immunol., 2008-11-01;38(11):3050-9.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
CXCL12 (SDF-1alpha) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells.
Authors: Meiron M, Zohar Y, Anunu R, Wildbaum G, Karin N
J. Exp. Med., 2008-10-13;205(11):2643-55.
Species: Mouse
Sample Types: In Vivo, Recombinant Protein
Applications: Neutralization, Western Blot -
Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents.
Authors: Shaked Y, Henke E, Roodhart JM, Mancuso P, Langenberg MH, Colleoni M, Daenen LG, Man S, Xu P, Emmenegger U, Tang T, Zhu Z, Witte L, Strieter RM, Bertolini F, Voest EE, Benezra R, Kerbel RS
Cancer Cell, 2008-09-09;14(3):263-73.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
Activation of bone marrow-derived microglia promotes photoreceptor survival in inherited retinal degeneration.
Authors: Sasahara M, Otani A, Oishi A, Kojima H, Yodoi Y, Kameda T, Nakamura H, Yoshimura N
Am. J. Pathol., 2008-05-15;172(6):1693-703.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
CXCL12 enhances exogenous CD4+CD25+ T cell migration and prevents embryo loss in non-obese diabetic mice.
Authors: Lin Y, Xu L, Jin H, Zhong Y, Di J, Lin QD
Fertil. Steril., 2008-04-02;91(6):2687-96.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Cloning and expression pattern of dog SDF-1 and the implications of altered expression of SDF-1 in ischemic myocardium.
Authors: Wei YJ, Tang Y, Li J, Cui CJ, Zhang H, Zhang XL, Zhang H, Hu SS
Cytokine, 2007-10-01;40(1):52-9.
Species: Canine
Sample Types: Tissue Homogenates
Applications: Western Blot -
Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury.
Authors: Petty JM, Sueblinvong V, Lenox CC, Jones CC, Cosgrove GP, Cool CD, Rai PR, Brown KK, Weiss DJ, Poynter ME, Suratt BT
J. Immunol., 2007-06-15;178(12):8148-57.
Species: Mouse
Sample Types: In Vivo, Whole Cells
Applications: Neutralization -
Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells.
Authors: Zhu J, Garrett R, Jung Y, Zhang Y, Kim N, Wang J, Joe GJ, Hexner E, Choi Y, Taichman RS, Emerson SG
Blood, 2007-01-16;109(9):3706-12.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
SDF-1 is both necessary and sufficient to promote proliferative retinopathy.
Authors: Butler JM, Guthrie SM, Koc M, Afzal A, Caballero S, Brooks HL, Mames RN, Segal MS, Grant MB, Scott EW
J. Clin. Invest., 2005-01-01;115(1):86-93.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
The role of CCL21 in recruitment of T-precursor cells to fetal thymi.
Authors: Ueno T, Kuse S, Saito F, Nitta T, Kakiuchi T, Hollander GA, Takahama Y
Blood, 2004-09-09;105(1):31-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
CXCR4 enhances adhesion of B16 tumor cells to endothelial cells in vitro and in vivo via beta(1) integrin.
Authors: Cardones AR, Murakami T, Hwang ST
Cancer Res., 2003-10-15;63(20):6751-7.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Serum inactivation contributes to the failure of stromal-derived factor-1 to block HIV-I infection in vivo.
Authors: Villalba S, Salvucci O, Aoki Y, De La Luz Sierra M, Gupta G, Davis D, Wyvill K, Little R, Yarchoan R, Tosato G
J. Leukoc. Biol., 2003-07-22;74(5):880-8.
Species: Human
Sample Types: Serum, Whole Cells
Applications: Flow Cytometry, Immunoprecipitation -
Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12
Authors: Chuangxin Lin, Liangliang Liu, Chun Zeng, Zhong-Kai Cui, Yuhui Chen, Pinling Lai et al.
Bone Research
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Muscle-derived SDF-1 alpha /CXCL12 modulates endothelial cell proliferation but not exercise training-induced angiogenesis
Authors: Mami Yamada, Chihiro Hokazono, Ken Tokizawa, Shuri Marui, Masahiro Iwata, Vitor A. Lira et al.
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
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CHEK2 represses breast stromal fibroblasts and their paracrine tumor-promoting effects through suppressing SDF-1 and IL-6
Authors: Maha A. Al-Rakan, Siti-Faujiah Hendrayani, Abdelilah Aboussekhra
BMC Cancer
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Bi-ligand surfaces with oriented and patterned protein for real-time tracking of cell migration
Authors: Varadraj N. Vernekar, Charles S. Wallace, Mina Wu, Joshua T. Chao, Shannon K. O’Connor, Aimee Raleigh et al.
Colloids and Surfaces B: Biointerfaces
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CD62Ldim Neutrophils Specifically Migrate to the Lung and Participate in the Formation of the Pre-Metastatic Niche of Breast Cancer
Authors: Zhen Wang, Chenghui Yang, Lili Li, Zhigang Zhang, Jun Pan, Ke Su et al.
Frontiers in Oncology
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A new obligate CXCL4-CXCL12 heterodimer for studying chemokine heterodimer activities and mechanisms
Authors: KTP Nguyen, B Volkman, D Dréau, IV Nesmelova
Scientific Reports, 2022-10-13;12(1):17204.
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Cytotoxic T cells swarm by homotypic chemokine signalling
Authors: Jorge Luis Galeano Niño, Sophie V Pageon, Szun S Tay, Feyza Colakoglu, Daryan Kempe, Jack Hywood et al.
eLife
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A novel CXCR4 antagonist counteracts paradoxical generation of cisplatin-induced pro-metastatic niches in lung cancer
Authors: Giulia Bertolini, Valeria Cancila, Massimo Milione, Giuseppe Lo Russo, Orazio Fortunato, Nadia Zaffaroni et al.
Molecular Therapy
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ROS-Induced CXCR4 Signaling Regulates Mantle Cell Lymphoma (MCL) Cell Survival and Drug Resistance in the Bone Marrow Microenvironment via Autophagy
Authors: Zheng Chen, Albert E. Teo, Nami McCarty
Clinical Cancer Research
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Annexin 2–CXCL12 Interactions Regulate Metastatic Cell Targeting and Growth in the Bone Marrow
Authors: Younghun Jung, Jingcheng Wang, Eunsohl Lee, Samantha McGee, Janice E. Berry, Kenji Yumoto et al.
Molecular Cancer Research
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Bone Marrow Suppression by c-Kit Blockade Enhances Tumor Growth of Colorectal Metastases through the Action of Stromal Cell-Derived Factor-1
Authors: Kathrin Rupertus, Gudrun C. Y. Haberl, Claudia Scheuer, Michael D. Menger, Martin K. Schilling, Otto Kollmar
Journal of Oncology
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