Human/Mouse CXCL12/SDF-1 Antibody Summary
Lys22-Lys89
Accession # Q6ICW0
Applications
Human/Mouse CXCL12/SDF-1 Sandwich Immunoassay
Human CXCL12/SDF-1 beta Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
CXCL12/SDF‑1 in Human PBMCs and K562 Human Cell Line. CXCL12/SDF-1 was detected in immersion fixed human peripheral blood mononuclear cells (PBMCs; positive staining) and K562 human chronic myelogenous leukemia cell line (negative staining) using Mouse Anti-Human/Mouse CXCL12/SDF-1 Monoclonal Antibody (Catalog # MAB350) at 8 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). Specific staining was localized to cell membranes. View our protocol for Fluorescent ICC Staining of Non-adherent Cells.
CXCL12/SDF‑1 in Human Tonsil. CXCL12/SDF‑1 was detected in immersion fixed paraffin-embedded sections of human tonsil using 15 µg/mL Human/Mouse CXCL12/SDF‑1 Monoclonal Antibody (Catalog # MAB350) overnight at 4 °C. Tissue was stained with the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific labeling was localized to epithelial cells in cripts. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
CXCL12/SDF‑1 in Human Tonsil. CXCL12/SDF‑1 was detected in immersion fixed paraffin-embedded sections of human tonsil using Human/Mouse CXCL12/SDF‑1 Monoclonal Antibody (Catalog # MAB350) at 25 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Detection of CXCL12/SDF‑1 in HT1080 Human Cell Line by Flow Cytometry. HT1080 human fibrosarcoma cell line was stained with Mouse Anti-Human/Mouse CXCL12/SDF-1 Monoclonal Antibody (Catalog # MAB350, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B). To facilitate intracellular staining, cells were fixed and permeabilized with FlowX FoxP3 Fixation & Permeabilization Buffer Kit (Catalog # FC012). View our protocol for Staining Intracellular Molecules.
CXCL12/SDF‑1 alpha in Human Tonsil Using Dual RNAscope®ISH and IHC. CXCL12/SDF-1a mRNA was detected in formalin-fixed paraffin-embedded tissue sections of human tonsil probed with ACD RNAScope®Probe (Catalog # 422991) and stained using ACD RNAscope®2.5 HD Detection Reagents-Red (top image, Catalog # 32260). Adjacent tissue section was processed for immunohistochemistry using R&D Systems Mouse Anti-Human CXCL12/SDF-1a Monoclonal Antibody (Catalog # MAB350) at 5 ug/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte HRP Polymer Antibody (R&D Systems, Catalog # VC001) and DAB chromogen (lower image, yellow-brown). Tissues were counterstained with hematoxylin (blue).
Detection of Human CXCL12/SDF-1 by Immunocytochemistry/Immunofluorescence CXCR4 and CXCL12 expression and BM infiltration. (a) Expression analysis of CXCR4 and CXCL12 in uninfiltrated and infiltrated bone marrow specimens at the time of diagnosis by RQ-PCR. (b) Expression analysis of CXCR4 and CXCL12 in infiltrated bone marrow biopsies and the respective paired sample in patients under remission by RQ-PCR. (c) Representative immunohistochemical stains of CXCR4 (I–II) and CXCL12 (III–IV) on selected bone marrow specimens of DLBCL patients (magnification 20×). (I) and (III) represent the CXCR4 and CXCL12 staining of uninfiltrated bone marrow specimens, and (II) and (IV) represent those of the infiltrated bone marrow specimens. mRNA expression levels were calculated as a relative expression in comparison to uninfiltrated bone marrow specimens. Each bar represents the mean values of expression levels ± standard error of the mean (SEM). The comparison of the expression levels was performed by using the Mann–Whitney U-test or the Student’s t-test. All images were captured using an Olympus BX51 microscope and an Olympus E-330 camera. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/31554271), licensed under a CC-BY license. Not internally tested by R&D Systems.
Detection of Mouse CXCL12/SDF-1 by Immunohistochemistry RhoA modulates the CXCR4-CXCL12 axis in breast tumors. (a) Representative immunohistochemical (IHC) staining images of breast primary tumor sections of mice orthotopically injected with 4T1 GFP-LUC cells carrying indicated lentiviral modifications, stained with antibodies for CD31 (top, left), F4/80 (middle, left) and alpha -SMA (bottom, left). CD31+ area (top, right), F4/80+ cells (middle, right) and alpha -SMA+ area (bottom, right) per tumor field of view (FOV) (mean ± SE) quantifications of IHC images. N = 4. (b) Representative IHC staining images of breast primary tumor sections of above mice stained with CXCL12 antibody (left). CXCL12+ area per tumor FOV (mean ± SE) quantification of IHC images. N = 4. (c) Representative immunofluorescent images of breast primary tumor sections of above mice co-stained with alpha -SMA, CXCL12 and DRAQ5 nuclear stain, showing the co-localization of alpha -SMA and CXCL12 signals. Scale bar: 50 µm. (d) Representative IHC staining images of breast primary tumor sections of above mice stained with CXCR4 antibody (left). CXCR4+ area per tumor FOV (mean ± SE) quantification of IHC images. N = 4. (e) Relative mCXCR4 mRNA levels normalized with mActin (mean ± SE), as quantified by qRT-PCR in primary breast tumors of above mice (top) and in 4T1 GFP-LUC cells carrying indicated lentiviral modifications (bottom). N = 4, ns- not significant *P < 0.05, unpaired Student’s t-test (two-tailed). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/31705019), licensed under a CC-BY license. Not internally tested by R&D Systems.
Detection of Human CXCL12/SDF-1 by Immunocytochemistry/Immunofluorescence CXCR4 and CXCL12 expression in DLBCL. (a) Expression analysis of CXCR4 and CXCL12 in non-neoplastic control germinal center B cells (GC-B) and diffuse large B cell lymphoma cells (DLBCL) consisting of DLBCL-NGCB and DLCBL-GCB, by RQ-PCR. GCB-DLBCL were further subdivided into primary (DLBCL-pGCB) and transformed DLBCL (DLBCL-pGCB) originating from follicular lymphoma. (b) Expression analysis of CXCR4 and CXCL12 in DLBCL samples with early (stage 1) and advanced stage (stage 2–4) (left graphs) and DLBCL samples with and without bone marrow infiltration (right graphs) by RQ-PCR. (c) Probability of 5-year-survival in DLBCL patients (our cohort left panel and the cohort of Lenz et al. right [20]) stratified by the third quartile of CXCR4 expression, respectively. (d) Representative immunohistochemical stains of CXCR4 (I–III) and CXCL12 (IV–VI) on DLBCL samples (magnification 20×). mRNA expression levels were calculated as a relative expression in comparison to the GC-B cells. All images were captured using an Olympus BX51 microscope and an Olympus E-330 camera. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/31554271), licensed under a CC-BY license. Not internally tested by R&D Systems.
Detection of Human Human/Mouse CXCL12/SDF-1 Antibody by Immunohistochemistry Tumor-promoting phenotype of the myeloid clusters.IHC staining demonstrating the expression of CD163, IL-6, IL-10, VEGF-A, MMP-9, SDF-1 and Bcl-xL by the myeloid cells associated with anthracosis. For each protein, representative images showing positive and negative staining areas were selected from the same slide. The quantification was performed by analyzing random images of myeloid cluster areas associated with anthracosis and other areas (10 images for each group) from 10 patients. Two-tailed Student's t-test was used for statistical analysis. Shown are means ± SEM, *** P<0.001. (Scale bar, 200 µm for 100× and 400×; 25 µm for 1600×) Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/23717691), licensed under a CC-BY license. Not internally tested by R&D Systems.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CXCL12/SDF-1
CXCL12, also known as SDF-1, is a CXC chemokine that interacts with CXCR4. SDF-1 alpha and SDF-1 beta are alternatively spliced isoforms of CXCL12. SDF-1 beta has an additional 4 amino acids at the carboxy-terminus.
Product Datasheets
Citations for Human/Mouse CXCL12/SDF-1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
149
Citations: Showing 1 - 10
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Fibroblast-derived CXCL12 increases vascular permeability in a 3-D microfluidic model independent of extracellular matrix contractility
Authors: Jacob C. Holter, Chia-Wen Chang, Alex Avendano, Ayush A. Garg, Ajeet K. Verma, Manish Charan et al.
Frontiers in Bioengineering and Biotechnology
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Redox-Mediated Mechanisms Fuel Monocyte Responses to CXCL12/HMGB1 in Active Rheumatoid Arthritis
Authors: Valentina Cecchinato, Gianluca D'Agostino, Lorenzo Raeli, Alessandra Nerviani, Milena Schiraldi, Gabriela Danelon et al.
Frontiers in Immunology
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Administration of a CXCL12 Analog in Endotoxemia Is Associated with Anti-Inflammatory, Anti-Oxidative and Cytoprotective Effects In Vivo.
Authors: Seemann S, Lupp A
PLoS ONE, 2015-09-16;10(9):e0138389.
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Comprehensive comparison of three different animal models for systemic inflammation
Authors: S Seemann, F Zohles, A Lupp
J. Biomed. Sci., 2017-08-24;24(1):60.
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Evaluation of the influence of the C-X-C motif chemokine ligand 12 / C-X-C chemokine receptor 4 axis on canine mammary gland tumor cell migration
Authors: Ayano KUDO, Hiroki SAWAHATA, Sho YOSHIMOTO, Akinori YAMAUCHI, Ryo OSHITA, Eiichi KANAI et al.
Journal of Veterinary Medical Science
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Macrophage fusion event as one prerequisite for inorganic nanoparticle-induced antitumor response
Authors: Chen S, Xing Z, Geng M et al.
Science advances
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Conditioned medium from umbilical cord mesenchymal stem cells induces migration and angiogenesis
Authors: CHONGYANG SHEN, PUCHANG LIE, TIANYU MIAO, MEIXING YU, QIAO LU, TING FENG et al.
Molecular Medicine Reports
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CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not
Authors: Maria Neve Polimeno, Caterina Ierano, Crescenzo D'Alterio, Nunzia Simona Losito, Maria Napolitano, Luigi Portella et al.
Cellular & Molecular Immunology
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A meta-analysis of CXCL12 expression for cancer prognosis
Authors: Harsh Samarendra, Keaton Jones, Tatjana Petrinic, Michael A Silva, Srikanth Reddy, Zahir Soonawalla et al.
British Journal of Cancer
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Hepatic stellate cells express functional CXCR4: role in stromal cell-derived factor-1alpha-mediated stellate cell activation
Authors: Feng Hong, Ana Tuyama, Ting Fang Lee, Johnny Loke, Ritu Agarwal, Xin Cheng et al.
Hepatology
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Oxidative stress promotes myofibroblast differentiation and tumour spreading
Authors: Aurore Toullec, Damien Gerald, Gilles Despouy, Brigitte Bourachot, Melissa Cardon, Sylvain Lefort et al.
EMBO Molecular Medicine
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Clinical significance of enlarged lateral pelvic lymph nodes before and after preoperative chemoradiotherapy for rectal cancer
Authors: YASUHIRO INOUE, SUSUMU SAIGUSA, JUNICHIRO HIRO, YUJI TOIYAMA, TOSHIMITSU ARAKI, KOJI TANAKA et al.
Molecular and Clinical Oncology
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Estrogen-dependent regulation of human uterine natural killer cells promotes vascular remodelling via secretion of CCL2
Authors: D.A. Gibson, E. Greaves, H.O.D. Critchley, P.T.K. Saunders
Human Reproduction
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Senescent tumor cells lead the collective invasion in thyroid cancer
Authors: Kim YH, Choi YW, Lee J et al.
Nat Commun.
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Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton
Authors: Madison L. Doolittle, Dominik Saul, Japneet Kaur, Jennifer L. Rowsey, Stephanie J. Vos, Kevin D. Pavelko et al.
bioRxiv
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Inflammatory Cell Distribution in Primary Merkel Cell Carcinoma
Authors: Rachel Wheat, Claudia Roberts, Tim Waterboer, Jane Steele, Jerry Marsden, Neil M. Steven et al.
Cancers (Basel)
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Chemokine axes CXCL12/CXCR4 and CXCL16/CXCR6 correlate with lymph node metastasis in epithelial ovarian carcinoma
Authors: Li Guo, Zhu-Mei Cui, Jia Zhang, Yu Huang
Chinese Journal of Cancer
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Identification of Leydig cell-specific mRNA transcripts in the adult rat testis
Authors: P J O'Shaughnessy, A Monteiro, P A Fowler, I D Morris
REPRODUCTION
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Recruitment of regulatory T cells is correlated with hypoxia-induced CXCR4 expression, and is associated with poor prognosis in basal-like breast cancers
Authors: Max Yan, Nicholas Jene, David Byrne, Ewan K A Millar, Sandra A O'Toole, Catriona M McNeil et al.
Breast Cancer Research
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Cellular Host Responses to Gliomas
Authors: Joseph Najbauer, Peter C. Huszthy, Michael E. Barish, Elizabeth Garcia, Marianne Z. Metz, Sarah M. Myers et al.
PLoS ONE
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Canine Bone Marrow Derived Mesenchymal Stromal Cells Suppress Allo-Reactive Lymphocyte Proliferation in Vitro but Fail to Enhance Engraftment in Canine Bone Marrow Transplantation
Authors: Won Sik Lee, Yasuhiro Suzuki, Scott S. Graves, Mineo Iwata, G.M. Venkataraman, Marco Mielcarek et al.
Biology of Blood and Marrow Transplantation
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Upregulation of stromal cell derived factor-1alpha in collagen vascular diseases-associated interstitial pneumonias (CVDs-IPs)
Authors: Giorgos A. Margaritopoulos, Katerina M. Antoniou, Giannoula Soufla, Konstantinos Karagiannis, Athanasia Proklou, Ismini Lasithiotaki et al.
Pulmonary Pharmacology & Therapeutics
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Early structural and functional plasticity alterations in a susceptibility period of DYT1 dystonia mouse striatum
Authors: M Maltese, J Stanic, A Tassone, G Sciamanna, G Ponterio, V Vanni, G Martella, P Imbriani, P Bonsi, NB Mercuri, F Gardoni, A Pisani
Elife, 2018-03-05;7(0):.
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The chemokine, CXCL12, is an independent predictor of poor survival in ovarian cancer
Authors: A Popple, L G Durrant, I Spendlove, P Rolland, I V Scott, S Deen et al.
British Journal of Cancer
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Fabrication of bone marrow-like tissue in vitro from dispersed-state bone marrow cells
Authors: Kanae Sayo, Shigehisa Aoki, Nobuhiko Kojima
Regenerative Therapy
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Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells
Authors: Donnelly, H;Ross, E;Xiao, Y;Hermantara, R;Taqi, AF;Doherty-Boyd, WS;Cassels, J;Tsimbouri, PM;Dunn, KM;Hay, J;Cheng, A;Meek, RMD;Jain, N;West, C;Wheadon, H;Michie, AM;Peault, B;West, AG;Salmeron-Sanchez, M;Dalby, MJ;
Nature communications
Species: Human
Sample Types: Whole Cells
Applications: Immunocytochemistry -
Distinct transcriptomic profile of satellite cells contributes to preservation of neuromuscular junctions in extraocular muscles of ALS mice
Authors: Li, A;Yi, J;Li, X;Dong, L;Ostrow, LW;Ma, J;Zhou, J;
eLife
Species: Mouse, Transgenic Mouse
Sample Types: Whole Tissue
Applications: Immunohistochemistry -
Generation of complex bone marrow organoids from human induced pluripotent stem cells
Authors: Frenz-Wiessner, S;Fairley, SD;Buser, M;Goek, I;Salewskij, K;Jonsson, G;Illig, D;Zu Putlitz, B;Petersheim, D;Li, Y;Chen, PH;Kalauz, M;Conca, R;Sterr, M;Geuder, J;Mizoguchi, Y;Megens, RTA;Linder, MI;Kotlarz, D;Rudelius, M;Penninger, JM;Marr, C;Klein, C;
Nature methods
Species: Human
Sample Types: Organoid
Applications: Immunohistochemistry -
Stromal-derived MAOB promotes prostate cancer growth and progression
Authors: Pu, T;Wang, J;Wei, J;Zeng, A;Zhang, J;Chen, J;Yin, L;Li, J;Lin, TP;Melamed, J;Corey, E;Gao, AC;Wu, BJ;
Science advances
Species: Human, Xenograft
Sample Types: Whole Tissue
Applications: Immunohistochemistry -
CXCL12 Neutralizing Antibody Promotes Hair Growth in Androgenic Alopecia and Alopecia Areata
Authors: Zheng, M;Kim, MH;Park, SG;Kim, WS;Oh, SH;Sung, JH;
International journal of molecular sciences
Species: Mouse
Sample Types: Whole Tissue
Applications: Immunohistochemistry -
CD13 facilitates immune cell migration and aggravates acute injury but promotes chronic post-stroke recovery
Authors: Nguyen, JN;Mohan, EC;Pandya, G;Ali, U;Tan, C;Kofler, JK;Shapiro, L;Marrelli, SP;Chauhan, A;
Journal of neuroinflammation
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Subventricular zone cytogenesis provides trophic support for neural repair in a mouse model of stroke
Authors: Williamson, MR;Le, SP;Franzen, RL;Donlan, NA;Rosow, JL;Nicot-Cartsonis, MS;Cervantes, A;Deneen, B;Dunn, AK;Jones, TA;Drew, MR;
Nature communications
Species: Transgenic Mouse
Sample Types: Whole Tissue
Applications: IHC -
Novel characterization of CXCR4 expressing cells in uninfected and herpes simplex virus-1 infected corneas
Authors: PK Suvas, M Setia, M Rana, A Chakrabort, S Suvas
The ocular surface, 2023-02-20;28(0):99-107.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Molecular Profiling of Tissue Samples with Chronic Rejection from Patients with Chronic Lung Allograft Dysfunction: A Pilot Study in Cystic Fibrosis Patients
Authors: F Lunardi, DI Abbrescia, L Vedovelli, F Pezzuto, F Fortarezza, GM Comacchio, V Guzzardo, P Ferrigno, M Loy, C Giraudo, AS Fraia, E Faccioli, F Braccioni, E Cozzi, D Gregori, GM Verleden, F Calabrese, FP Schena, F Rea
Biomolecules, 2023-01-03;13(1):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Novel characterization of CXCR4 expressing cells in uninfected and herpes simplex virus-1 infected corneas
Authors: PK Suvas, M Setia, M Rana, A Chakrabort, S Suvas
The ocular surface, 2023;28(0):99-107.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
CXCR4-CXCL12-CXCR7 and PD-1/PD-L1 in Pancreatic Cancer: CXCL12 Predicts Survival of Radically Resected Patients
Authors: C D'Alterio, A Giardino, G Scognamigl, G Butturini, L Portella, G Guardascio, I Frigerio, M Montella, S Gobbo, G Martignoni, V Napolitano, F De Vita, F Tatangelo, R Franco, S Scala
Cells, 2022-10-22;11(21):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization
Authors: YW Dai, JK Ma, R Jiang, XL Zhan, SY Chen, LL Feng, Q Zhang, TB Liang, K Lv, GJ Yang, JF Lu, J Chen, XJ Lu
Cell Reports, 2022-09-20;40(12):111361.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: ELISA Capture -
Peripheral apoE4 enhances Alzheimer's pathology and impairs cognition by compromising cerebrovascular function
Authors: CC Liu, J Zhao, Y Fu, Y Inoue, Y Ren, Y Chen, SV Doss, F Shue, S Jeevaratna, L Bastea, N Wang, YA Martens, W Qiao, M Wang, N Zhao, L Jia, Y Yamazaki, A Yamazaki, CL Rosenberg, Z Wang, D Kong, Z Li, LA Kuchenbeck, ZA Trottier, L Felton, J Rogers, ZS Quicksall, C Linares, J Knight, Y Chen, A Kurti, T Kanekiyo, JD Fryer, YW Asmann, P Storz, X Wang, J Peng, B Zhang, BYS Kim, G Bu
Nature Neuroscience, 2022-08-01;25(8):1020-1033.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression
Authors: II Verginadis, H Avgousti, J Monslow, G Skoufos, F Chinga, K Kim, NM Leli, IV Karagounis, BI Bell, A Velalopoul, CS Salinas, VS Wu, Y Li, J Ye, DA Scott, AL Osterman, A Sengupta, A Weljie, M Huang, D Zhang, Y Fan, E Radaelli, JW Tobias, F Rambow, P Karras, JC Marine, X Xu, AG Hatzigeorg, S Ryeom, JA Diehl, SY Fuchs, E Puré, C Koumenis
Nature Cell Biology, 2022-06-02;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Biological Role of Tumor/Stromal CXCR4-CXCL12-CXCR7 in MITO16A/MaNGO-OV2 Advanced Ovarian Cancer Patients
Authors: C D'Alterio, A Spina, L Arenare, P Chiodini, M Napolitano, F Galdiero, L Portella, V Simeon, S Signoriell, F Raspaglies, D Lorusso, C Pisano, N Colombo, GF Zannoni, NS Losito, R De Cecio, G Scognamigl, D Califano, D Russo, V Tuninetti, MC Piccirillo, P Gargiulo, F Perrone, S Pignata, S Scala
Cancers, 2022-04-06;14(7):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Preservation of the na�ve features of mesenchymal stromal cells in vitro: Comparison of cell- and bone-derived decellularized extracellular matrix
Authors: AR Pereira, D Trivanovi?, P Stahlhut, M Rudert, J Groll, M Herrmann
Journal of tissue engineering, 2022-02-07;13(0):2041731422107.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis
Authors: C Fielding, A García-Gar, C Korn, S Gadomski, Z Fang, JL Reguera, JA Pérez-Simó, B Göttgens, S Méndez-Fer
Nature Communications, 2022-01-27;13(1):543.
Species: Mouse
Sample Types: Bone Marrow Lavage Fluid
Applications: ELISA Capture -
Stimulated Expression of CXCL12 in Adrenocortical Carcinoma by the PPARgamma Ligand Rosiglitazone Impairs Cancer Progression
Authors: G Cantini, L Fei, L Canu, E Lazzeri, M Sottili, M Francalanc, ML Angelotti, G De Filpo, T Ercolino, S Gelmini, M Mangoni, G Nesi, C Hantel, M Mannelli, M Maggi, M Luconi
Journal of personalized medicine, 2021-10-27;11(11):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Microbiota-derived lactate promotes hematopoiesis and erythropoiesis by inducing stem cell factor production from leptin receptor+ niche cells
Authors: YS Lee, TY Kim, Y Kim, S Kim, SH Lee, SU Seo, BO Zhou, O Eunju, KS Kim, MN Kweon
Experimental & Molecular Medicine, 2021-09-09;0(0):.
Species: Mouse
Sample Types: Whole Cells, Whole Tissue
Applications: ICC, IHC -
Plasma cell dynamics in the bone marrow niche
Authors: Z Benet, Z Jing, DR Fooksman
Cell Reports, 2021-02-09;34(6):108733.
Species: Mouse
Sample Types: Whole Cells
Applications: ELISA Development -
CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response
Authors: D Biasci, M Smoragiewi, CM Connell, Z Wang, Y Gao, JED Thaventhir, B Basu, L Magiera, TI Johnson, L Bax, A Gopinathan, C Isherwood, FA Gallagher, M Pawula, I Hudecova, D Gale, N Rosenfeld, P Barmpounak, EC Popa, R Brais, E Godfrey, F Mir, FM Richards, DT Fearon, T Janowitz, DI Jodrell
Proc Natl Acad Sci U S A, 2020-10-30;0(0):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
New CXCR4 Antagonist Peptide R (Pep R) Improves Standard Therapy in Colorectal Cancer
Authors: C D'Alterio, A Zannetti, AM Trotta, C Ieranò, M Napolitano, G Rea, A Greco, P Maiolino, S Albanese, G Scognamigl, F Tatangelo, S Tafuto, L Portella, S Santagata, G Nasti, A Ottaiano, R Pacelli, P Delrio, G Botti, S Scala
Cancers (Basel), 2020-07-18;12(7):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Engineered scaffolds based on mesenchymal stem cells/preosteoclasts extracellular matrix promote bone regeneration
Authors: R Dong, Y Bai, J Dai, M Deng, C Zhao, Z Tian, F Zeng, W Liang, L Liu, S Dong
J Tissue Eng, 2020-06-07;11(0):2041731420926.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
SOX4 activates CXCL12 in hepatocellular carcinoma cells to modulate endothelial cell migration and angiogenesis in vivo
Authors: CN Tsai, SC Yu, CW Lee, JS Pang, CH Wu, SE Lin, YH Chung, CL Tsai, SY Hsieh, MC Yu
Oncogene, 2020-05-13;0(0):.
Species: Human
Sample Types:
Applications: Functional Assay -
The lymph node stromal laminin alpha 5 shapes alloimmunity
Authors: L Li, MW Shirkey, T Zhang, Y Xiong, W Piao, V Saxena, C Paluskievi, YS Lee, N Toney, BM Cerel, Q Li, T Simon, KD Smith, KL Hippen, BR Blazar, R Abdi, JS Bromberg
J. Clin. Invest., 2020-05-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Prognostic Value of SDF-1alpha Expression in Patients with Esophageal Squamous Cell Carcinoma Receiving Esophagectomy
Authors: YH Chen, SH Li, HI Lu, CM Lo
Cancers (Basel), 2020-04-25;12(5):.
Species: Human
Sample Types: Whole Cells, Whole Tissue
Applications: IHC, Neutralization -
Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling
Authors: J Zheng, D Qu, C Wang, L Ding, W Zhou
BMC Pregnancy Childbirth, 2020-02-10;20(1):87.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Acetyl-L-Carnitine downregulates invasion (CXCR4/CXCL12, MMP-9) and angiogenesis (VEGF, CXCL8) pathways in prostate cancer cells: rationale for prevention and interception strategies
Authors: D Baci, A Bruno, C Cascini, M Gallazzi, L Mortara, F Sessa, G Pelosi, A Albini, DM Noonan
J. Exp. Clin. Cancer Res., 2019-11-12;38(1):464.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Paclitaxel-activated astrocytes produce mechanical allodynia in mice by releasing tumor necrosis factor-alpha and stromal-derived cell factor 1
Authors: X Liu, R Tonello, Y Ling, YJ Gao, T Berta
J Neuroinflammation, 2019-11-10;16(1):209.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Reduced RhoA expression enhances breast cancer metastasis with a concomitant increase in CCR5 and CXCR4 chemokines signaling
Authors: G Kalpana, C Figy, M Yeung, KC Yeung
Sci Rep, 2019-11-08;9(1):16351.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
The CXCR4-CXCL12-Axis Is of Prognostic Relevance in DLBCL and Its Antagonists Exert Pro-Apoptotic Effects In Vitro
Authors: K Pansy, J Feichtinge, B Ehall, B Uhl, M Sedej, D Roula, B Pursche, A Wolf, M Zoidl, E Steinbauer, V Gruber, HT Greinix, KT Prochazka, GG Thallinger, A Heinemann, C Beham-Schm, P Neumeister, TM Wrodnigg, K Fechter, AJ Deutsch
Int J Mol Sci, 2019-09-24;20(19):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Age-related differences in the bone marrow stem cell niche generate specialized microenvironments for the distinct regulation of normal hematopoietic and leukemia stem cells
Authors: GY Lee, SY Jeong, HR Lee, IH Oh
Sci Rep, 2019-01-30;9(1):1007.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
The Role of CXCL12 Axis in Lung Metastasis of Colorectal Cancer
Authors: M Wang, X Yang, M Wei, Z Wang
J Cancer, 2018-10-10;9(21):3898-3903.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Senescent fibroblasts drive ageing pigmentation: ?A potential therapeutic target for senile lentigo
Authors: JE Yoon, Y Kim, S Kwon, M Kim, YH Kim, JH Kim, TJ Park, HY Kang
Theranostics, 2018-09-09;8(17):4620-4632.
Species: Human
Sample Types: Whole Cells, Whole Tissue
Applications: ICC, IHC-P -
CXCR4 and its ligand CXCL12 display opposite expression profiles in feline mammary metastatic disease, with the exception of HER2-overexpressing tumors
Authors: CS Marques, AR Santos, A Gameiro, J Correia, F Ferreira
BMC Cancer, 2018-07-16;18(1):741.
Species: Feline
Sample Types: Whole Tissue
Applications: IHC -
CXCR4/CXCL12 Signaling and Protumor Macrophages in Primary Tumors and Sentinel Lymph Nodes Are Involved in Luminal B Breast Cancer Progression
Authors: C Raschioni, G Bottai, A Sagona, V Errico, A Testori, W Gatzemeier, F Corsi, C Tinterri, M Roncalli, L Santarpia, L Di Tommaso
Dis. Markers, 2018-04-16;2018(0):5018671.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Delayed and repeated intranasal delivery of bone marrow stromal cells increases regeneration and functional recovery after ischemic stroke in mice
Authors: MJ Chau, TC Deveau, X Gu, YS Kim, Y Xu, SP Yu, L Wei
BMC Neurosci, 2018-04-12;19(1):20.
Species: Rat
Sample Types: Whole Cells
Applications: ICC -
Tumor Microenvironment in Functional Adrenocortical Adenomas: Immune Cell Infiltration in Cortisol-producing Adrenocortical Adenoma
Authors: Y Kitawaki, Y Nakamura, F Kubota-Nak, Y Yamazaki, Y Miki, S Hata, K Ise, K Kikuchi, R Morimoto, F Satoh, H Sasano
Hum. Pathol., 2018-03-27;0(0):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Expression of CXC-motif-chemokine 12 and the receptor C-X-C receptor 4 in glioma and theeffect on peritumoral brain edema
Authors: W Tang, Y Chen, X Wang, Y Chen, J Zhang, Z Lin
Oncol Lett, 2017-12-08;15(2):2501-2507.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Mechanisms by which CXCR4/CXCL12 cause metastatic behavior in pancreatic cancer
Authors: J Zhang, C Liu, X Mo, H Shi, S Li
Oncol Lett, 2017-12-05;15(2):1771-1776.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
The chronically inflamed central nervous system provides niches for long-lived plasma cells
Authors: K Pollok, R Mothes, C Ulbricht, A Liebheit, JD Gerken, S Uhlmann, F Paul, R Niesner, H Radbruch, AE Hauser
Acta Neuropathol Commun, 2017-11-25;5(1):88.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
Regulation of inflammatory factors by double-stranded RNA receptors in breast cancer cells
Authors: A Venkatesh, H Nandigam, M Muccioli, M Singh, T Loftus, D Lewis, M Pate, F Benencia
Immunobiology, 2017-11-22;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: ELISA Development (Capture) -
Cancer associated fibroblasts (CAFs) are activated in cutaneous basal cell carcinoma and in the peritumoural skin
Authors: SH Omland, EE Wettergren, S Mollerup, M Asplund, T Mourier, AJ Hansen, R Gniadecki
BMC Cancer, 2017-10-07;17(1):675.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-Fr -
Increasing tumor-infiltrating T cells through inhibition of CXCL12 with NOX-A12 synergizes with PD-1 blockade
Authors: D Zboralski, K Hoehlig, D Eulberg, A Froemming, A Vater
Cancer Immunol Res, 2017-09-28;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
SDF-1/CXCR4 expression in head and neck cancer and outcome after postoperative radiochemotherapy
Authors: C De-Colle, D Mönnich, S Welz, S Boeke, B Sipos, F Fend, PS Mauz, I Tinhofer, V Budach, JA Jawad, M Stuschke, P Balermpas, C Rödel, AL Grosu, A Abdollahi, J Debus, C Bayer, C Belka, S Pigorsch, SE Combs, F Lohaus, A Linge, M Krause, M Baumann, D Zips, A Menegakis
Clin Transl Radiat Oncol, 2017-07-14;5(0):28-36.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Hypoxia-Inducible Factor 1? Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury
Authors: J McClendon, NL Jansing, EF Redente, A Gandjeva, Y Ito, SP Colgan, A Ahmad, DWH Riches, HA Chapman, RJ Mason, RM Tuder, RL Zemans
Am. J. Pathol., 2017-06-12;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Dipeptidyl Peptidase-4 Inhibition Stimulates Distal Tubular Natriuresis and Increases in Circulating SDF-1?(1-67) in Patients With Type 2 Diabetes
Authors: JA Lovshin, H Rajasekera, Y Lytvyn, LE Lovblom, S Khan, R Alemu, A Locke, V Lai, H He, L Hittle, W Wang, DJ Drucker, DZI Cherney
Diabetes Care, 2017-05-26;0(0):.
Species: Human
Sample Types: Plasma
Applications: Mass Spectrometry -
A novel recombinant antibody specific to full-length stromal derived factor-1 for potential application in biomarker studies
Authors: DI Bromage, S Taferner, M Pillai, DM Yellon, SM Davidson
PLoS ONE, 2017-04-05;12(4):e0174447.
Species: Human, Rat
Sample Types: Plasma, Recombinant Protein
Applications: ELISA Development (Detection), Functional Assay -
Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells
Authors: N Guidi, M Sacma, L Ständker, K Soller, G Marka, K Eiwen, JM Weiss, F Kirchhoff, T Weil, JA Cancelas, MC Florian, H Geiger
EMBO J, 2017-03-02;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: ELISA Development (Capture) -
Cholinergic Signals from the CNS Regulate G-CSF-Mediated HSC Mobilization from Bone Marrow via a Glucocorticoid Signaling Relay
Authors: H Pierce, D Zhang, C Magnon, D Lucas, JR Christin, M Huggins, GJ Schwartz, PS Frenette
Cell Stem Cell, 2017-02-09;0(0):.
Species: Mouse
Sample Types: Bone Marrow Fluid
Applications: ELISA Development (Capture) -
Expression and function of CXCL12/CXCR4/CXCR7 in thyroid cancer
Authors: X Zhu, Q Bai, Y Lu, Y Lu, L Zhu, X Zhou, L Wu
Int J Oncol, 2016-04-12;0(0):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
CXCR4 promotes renal tubular cell survival in male diabetic rats: implications for ligand inactivation in the human kidney.
Authors: Siddiqi, Ferhan S, Chen, Li-Hao, Advani, Suzanne, Thai, Kerri, Batchu, Sri N, Alghamdi, Tamadher, White, Kathryn, Sood, Manish M, Gibson, Ian W, Connelly, Kim A, Marsden, Philip A, Advani, Andrew
Endocrinology, 2014-12-30;156(3):1121-32.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC-P -
Immunohistochemical evaluation of CXCL12-CXCR4 axis and VEGFR3 expression in primary urothelial cancer and its recurrence.
Authors: Batsi O, Giannopoulou I, Nesseris I, Valavanis C, Gakiopoulou H, Patsouris E, Arapandoni-Dadioti P, Lazaris A
Anticancer Res, 2014-07-01;34(7):3537-42.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Stromal niche communalities underscore the contribution of the matricellular protein SPARC to B-cell development and lymphoid malignancies.
Authors: Sangaletti, Sabina, Tripodo, Claudio, Portararo, Paola, Dugo, Matteo, Vitali, Caterina, Botti, Laura, Guarnotta, Carla, Cappetti, Barbara, Gulino, Alessand, Torselli, Ilaria, Casalini, Patrizia, Chiodoni, Claudia, Colombo, Mario P
Oncoimmunology, 2014-06-05;3(0):e28989.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
CXCL16 and CXCR6 are coexpressed in human lung cancer in vivo and mediate the invasion of lung cancer cell lines in vitro.
Authors: Hu, Weidong, Liu, Yue, Zhou, Wenhui, Si, Lianlian, Ren, Liang
PLoS ONE, 2014-06-04;9(6):e99056.
Species: Human
Sample Types: Whole Cells, Whole Tissue
Applications: ICC, IHC-P -
CXCR4 is dispensable for T cell egress from chronically inflamed skin via the afferent lymph.
Authors: Geherin, Skye A, Wilson, R Paul, Jennrich, Silke, Debes, Gudrun F
PLoS ONE, 2014-04-21;9(4):e95626.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Regulation of transplanted mesenchymal stem cells by the lung progenitor niche in rats with chronic obstructive pulmonary disease.
Authors: Zhang W, He L, Shi X, Wu S, Zhang B, Mei L, Xu Y, Zhang Z, Zhao J, Zhang H
Respir Res, 2014-03-25;15(0):33.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC-P -
SDF-1/CXCR4 signaling preserves microvascular integrity and renal function in chronic kidney disease.
Authors: Chen L, Advani S, Thai K, Kabir M, Sood M, Gibson I, Yuen D, Connelly K, Marsden P, Kelly D, Gilbert R, Advani A
PLoS ONE, 2014-03-17;9(3):e92227.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis.
Authors: Roy, Ishan, Zimmerman, Noah P, Mackinnon, A Craig, Tsai, Susan, Evans, Douglas, Dwinell, Michael
PLoS ONE, 2014-03-04;9(3):e90400.
Species: Human
Sample Types: Cell Culture Supernates, Whole Tissue
Applications: ELISA Development (Capture), IHC -
Intracellular coexpression of CXC- and CC- chemokine receptors and their ligands in human melanoma cell lines and dynamic variations after xenotransplantation.
Authors: Pinto S, Martinez-Romero A, O'Connor J, Gil-Benso R, San-Miguel T, Terradez L, Monteagudo C, Callaghan R
BMC Cancer, 2014-02-22;14(0):118.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry, ICC -
Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats.
Authors: Walters, M J, Ebsworth, K, Berahovich, R D, Penfold, M E T, Liu, S-C, Al Omran, R, Kioi, M, Chernikova, S B, Tseng, D, Mulkearns-Hubert, E E, Sinyuk, M, Ransohoff, R M, Lathia, J D, Karamchandani, J, Kohrt, H E K, Zhang, P, Powers, J P, Jaen, J C, Schall, T J, Merchant, M, Recht, L, Brown, J M
Br J Cancer, 2014-01-14;110(5):1179-88.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients.
Authors: D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, Pelella A, D'Armiento F, Carlomagno C, Bianco F, Silvestro L, Pacelli R, Napolitano M, Iaffaioli R, Scala S
Int J Cancer, 2014-01-10;135(2):379-90.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
A novel, diffusely infiltrative xenograft model of human anaplastic oligodendroglioma with mutations in FUBP1, CIC, and IDH1.
Authors: Klink B, Miletic H, Stieber D, Huszthy P, Campos Valenzuela J, Balss J, Wang J, Schubert M, Sakariassen P, Sundstrom T, Torsvik A, Aarhus M, Mahesparan R, von Deimling A, Kaderali L, Niclou S, Schrock E, Bjerkvig R, Nigro J
PLoS ONE, 2013-03-19;8(3):e59773.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
CXCL12 promotes the stabilization of atherosclerotic lesions mediated by smooth muscle progenitor cells in Apoe-deficient mice.
Authors: Akhtar S, Gremse F, Kiessling F, Weber C, Schober A
Arterioscler Thromb Vasc Biol, 2013-02-07;33(4):679-86.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Involvement of the CXCR7/CXCR4/CXCL12 axis in the malignant progression of human neuroblastoma.
Authors: Liberman J, Sartelet H, Flahaut M, Muhlethaler-Mottet A, Coulon A, Nyalendo C, Vassal G, Joseph J, Gross N
PLoS ONE, 2012-08-20;7(8):e43665.
Species: Human
Sample Types: Whole Cells, Whole Tissue
Applications: ICC, IHC-P -
The SDF-1α/CXCR4 Axis is Required for Proliferation and Maturation of Human Fetal Pancreatic Endocrine Progenitor Cells.
Authors: Kayali AG, Lopez AD, Hao E, Hinton A, Hayek A, King CC
PLoS ONE, 2012-06-22;7(6):e38721.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
A dynamic inflammatory cytokine network in the human ovarian cancer microenvironment.
Authors: Kulbe H, Chakravarty P, Leinster DA, Charles KA, Kwong J, Thompson RG, Coward JI, Schioppa T, Robinson SC, Gallagher WM, Galletta L, Salako MA, Smyth JF, Hagemann T, Brennan DJ, Bowtell DD, Balkwill FR
Cancer Res., 2011-11-07;72(1):66-75.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
VEGF-DdeltaNdeltaC mediated angiogenesis in skeletal muscles of diabetic WHHL rabbits.
Authors: Roy H, Bhardwaj S, Babu M, Lahteenvuo JE, Yla-Herttuala S
Eur. J. Clin. Invest., 2010-05-01;40(5):422-32.
Species: Rabbit
Sample Types: Whole Tissue
Applications: IHC-P -
Comprehensive assessment of chemokine expression profiles by flow cytometry.
Authors: Eberlein J, Nguyen TT, Victorino F, Golden-Mason L, Rosen HR, Homann D
J. Clin. Invest., 2010-02-08;120(3):907-23.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes.
Authors: Sayyed SG, Hagele H, Kulkarni OP, Endlich K, Segerer S, Eulberg D, Klussmann S, Anders HJ
Diabetologia, 2009-08-26;52(11):2445-54.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
Targeted disruption of the CXCL12/CXCR4 axis inhibits osteolysis in a murine model of myeloma-associated bone loss.
Authors: Diamond P, Labrinidis A, Martin SK, Farrugia AN, Gronthos S, To LB, Fujii N, O'Loughlin PD, Evdokiou A, Zannettino AC
J. Bone Miner. Res., 2009-07-01;24(7):1150-61.
Species: Human
Sample Types: Whole Cells, Whole Tissue
Applications: Flow Cytometry, IHC-P -
CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy.
Authors: Zhu Y, Vergote D, Pardo C, Noorbakhsh F, McArthur JC, Hollenberg MD, Overall CM, Power C
FASEB J., 2009-04-20;23(9):2928-41.
Species: Feline
Sample Types: Tissue Homogenates
Applications: Western Blot -
Clinical and biological significance of CXCL12 and CXCR4 expression in adult testes and germ cell tumours of adults and adolescents.
Authors: Gilbert DC, Chandler I, McIntyre A, Goddard NC, Gabe R, Huddart RA, Shipley J
J. Pathol., 2009-01-01;217(1):94-102.
Species: Human
Sample Types: Whole Cells, Whole Tissue
Applications: ICC, IHC-P -
Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4.
Authors: Struyf S, Noppen S, Loos T, Mortier A, Gouwy M, Verbeke H, Huskens D, Luangsay S, Parmentier M, Geboes K, Schols D, Van Damme J, Proost P
J. Immunol., 2009-01-01;182(1):666-74.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment.
Authors: Albanesi C, Scarponi C, Pallotta S, Daniele R, Bosisio D, Madonna S, Fortugno P, Gonzalvo-Feo S, Franssen JD, Parmentier M, De Pita O, Girolomoni G, Sozzani S
J. Exp. Med., 2008-12-29;206(1):249-58.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo.
Authors: Biancotto A, Iglehart SJ, Lisco A, Vanpouille C, Grivel JC, Lurain NS, Reichelderfer PS, Margolis LB
AIDS Res. Hum. Retroviruses, 2008-03-01;24(3):453-62.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Luminex Development -
pVHL co-ordinately regulates CXCR4/CXCL12 and MMP2/MMP9 expression in human clear-cell renal cell carcinoma.
Authors: Struckmann K, Mertz K, Steu S, Storz M, Staller P, Krek W, Schraml P, Moch H
J. Pathol., 2008-03-01;214(4):464-71.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Hypoxia-induced mediators of stem/progenitor cell trafficking are increased in children with hemangioma.
Authors: Kleinman ME, Greives MR, Churgin SS, Blechman KM, Chang EI, Ceradini DJ, Tepper OM, Gurtner GC
Arterioscler. Thromb. Vasc. Biol., 2007-09-13;27(12):2664-70.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury.
Authors: Petty JM, Sueblinvong V, Lenox CC, Jones CC, Cosgrove GP, Cool CD, Rai PR, Brown KK, Weiss DJ, Poynter ME, Suratt BT
J. Immunol., 2007-06-15;178(12):8148-57.
Species: Human, Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
Dynamic stromal-epithelial interactions during progression of MCF10DCIS.com xenografts.
Authors: Tait LR, Pauley RJ, Santner SJ, Heppner GH, Heng HH, Rak JW, Miller FR
Int. J. Cancer, 2007-05-15;120(10):2127-34.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.
Authors: Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM
Blood, 2007-02-08;109(10):4272-9.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Luminex Development -
HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1.
Authors: Grivel JC, Elliott J, Lisco A, Biancotto A, Condack C, Shattock RJ, McGowan I, Margolis L, Anton P
AIDS, 2007;21(10):1263-72.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Luminex Development -
HIV-1-infected and/or immune activated macrophages regulate astrocyte SDF-1 production through IL-1beta.
Authors: Peng H, Erdmann N, Whitney N, Dou H, Gorantla S, Gendelman HE, Ghorpade A, Zheng J
Glia, 2006-11-01;54(6):619-29.
Species: Human, Mouse
Sample Types: Cell Culture Supernates, Whole Tissue
Applications: ELISA Development, IHC-P -
Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis.
Authors: Marchal-Somme J, Uzunhan Y, Marchand-Adam S, Valeyre D, Soumelis V, Crestani B, Soler P
J. Immunol., 2006-05-15;176(10):5735-9.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-Fr -
Importance of recruitment of bone marrow-derived CXCR4+ cells in post-infarct cardiac repair mediated by G-CSF.
Authors: Misao Y, Takemura G, Arai M, Ohno T, Onogi H, Takahashi T, Minatoguchi S, Fujiwara T, Fujiwara H
Cardiovasc. Res., 2006-05-09;71(3):455-65.
Species: Rabbit
Sample Types: Tissue Homogenates, Whole Tissue
Applications: IHC-P, Western Blot -
Hyaluronan-based polymer scaffold modulates the expression of inflammatory and degradative factors in mesenchymal stem cells: Involvement of Cd44 and Cd54.
Authors: Lisignoli G, Cristino S, Piacentini A, Cavallo C, Caplan AI, Facchini A
J. Cell. Physiol., 2006-05-01;207(2):364-73.
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA Development -
Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer.
Authors: Yasumoto K, Koizumi K, Kawashima A, Saitoh Y, Arita Y, Shinohara K, Minami T, Nakayama T, Sakurai H, Takahashi Y, Yoshie O, Saiki I
Cancer Res., 2006-02-15;66(4):2181-7.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells.
Authors: Infantino S, Moepps B, Thelen M
J. Immunol., 2006-02-15;176(4):2197-207.
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA Development -
Regulation of SDF-1 (CXCL12) production by osteoblasts; a possible mechanism for stem cell homing.
Authors: Jung Y, Wang J, Schneider A, Sun YX, Koh-Paige AJ, Osman NI, McCauley LK, Taichman RS
Bone, 2005-12-05;38(4):497-508.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
Skin homing of Sezary cells involves SDF-1-CXCR4 signaling and down-regulation of CD26/dipeptidylpeptidase IV.
Authors: Narducci MG, Scala E, Bresin A, Caprini E, Picchio MC, Remotti D, Ragone G, Nasorri F, Frontani M, Arcelli D, Volinia S, Lombardo GA, Baliva G, Napolitano M, Russo G
Blood, 2005-10-04;107(3):1108-15.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Age-associated aortic stenosis in apolipoprotein E-deficient mice.
Authors: Tanaka K, Sata M, Fukuda D, Suematsu Y, Motomura N, Takamoto S, Hirata Y, Nagai R
J. Am. Coll. Cardiol., 2005-07-05;46(1):134-41.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of bone.
Authors: Liao TS, Yurgelun MB, Chang SS, Zhang HZ, Murakami K, Blaine TA, Parisien MV, Kim W, Winchester RJ, Lee FY
J. Orthop. Res., 2005-01-01;23(1):203-9.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands.
Authors: Kohrgruber N, Groger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, Stingl G, Rot A, Maurer D
J. Immunol., 2004-12-01;173(11):6592-602.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Thymic T cell development and progenitor localization depend on CCR7.
Authors: Misslitz A, Pabst O, Hintzen G, Ohl L, Kremmer E, Petrie HT, Forster R
J. Exp. Med., 2004-08-09;200(4):481-91.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus.
Authors: Wald O, Pappo O, Safadi R, Dagan-Berger M, Beider K, Wald H, Franitza S, Weiss I, Avniel S, Boaz P, Hanna J, Zamir G, Eid A, Mandelboim O, Spengler U, Galun E, Peled A
Eur. J. Immunol., 2004-04-01;34(4):1164-74.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Characterization of hematopoietic progenitor mobilization in protease-deficient mice.
Authors: Levesque JP, Liu F, Simmons PJ, Betsuyaku T, Senior RM, Pham C, Link DC
Blood, 2004-03-09;104(1):65-72.
Species: Mouse
Sample Types: Bone Marrow Fluid
Applications: ELISA Development -
Serum inactivation contributes to the failure of stromal-derived factor-1 to block HIV-I infection in vivo.
Authors: Villalba S, Salvucci O, Aoki Y, De La Luz Sierra M, Gupta G, Davis D, Wyvill K, Little R, Yarchoan R, Tosato G
J. Leukoc. Biol., 2003-07-22;74(5):880-8.
Species: Human
Sample Types: Serum
Applications: ELISA Development -
Stromal cell-derived factor-1 (CXCL12) activates integrins by direct binding to an allosteric ligand-binding site (site 2) of integrins without CXCR4.
Authors: Masaaki Fujita, Parastoo Davari, Yoko K. Takada, Yoshikazu Takada
Biochemical Journal
-
MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer
Authors: Lucia Suarez-Lopez, Yi Wen Kong, Ganapathy Sriram, Jesse C. Patterson, Samantha Rosenberg, Sandra Morandell et al.
Frontiers in Immunology
-
Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections
Authors: Alan Bénard, Anne Jacobsen, Maximilian Brunner, Christian Krautz, Bettina Klösch, Izabela Swierzy et al.
Nature Communications
-
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche
Authors: Andrew Chow, Daniel Lucas, Andrés Hidalgo, Simón Méndez-Ferrer, Daigo Hashimoto, Christoph Scheiermann et al.
Journal of Experimental Medicine
-
Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease
Authors: Tobias Petzold, Zhe Zhang, Iván Ballesteros, Inas Saleh, Amin Polzin, Manuela Thienel et al.
Immunity
-
Muscle-derived SDF-1 alpha /CXCL12 modulates endothelial cell proliferation but not exercise training-induced angiogenesis
Authors: Mami Yamada, Chihiro Hokazono, Ken Tokizawa, Shuri Marui, Masahiro Iwata, Vitor A. Lira et al.
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
-
CXCL12 expression promotes esophageal squamous cell carcinoma proliferation and worsens the prognosis
Authors: Yusuke Uchi, Hiroya Takeuchi, Sachiko Matsuda, Yoshiro Saikawa, Hirofumi Kawakubo, Norihito Wada et al.
BMC Cancer
-
High expression of CXCR4, CXCR7 and SDF-1 predicts poor survival in renal cell carcinoma
Authors: Linhui Wang, Wei Chen, Li Gao, Qing Yang, Bing Liu, Zhenjie Wu et al.
World Journal of Surgical Oncology
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Human cytomegalovirus infection inhibits CXCL12- mediated migration and invasion of human extravillous cytotrophoblasts
Authors: Jessica A Warner, Kevin J Zwezdaryk, Bonita Day, Deborah E Sullivan, Gabriella Pridjian, Cindy A Morris
Virology Journal
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Increased oxidative stress and severe arterial remodeling induced by permanent high-flow challenge in experimental pulmonary hypertension
Authors: Peter Dorfmüller, Marie-Camille Chaumais, Maria Giannakouli, Ingrid Durand-Gasselin, Nicolas Raymond, Elie Fadel et al.
Respiratory Research
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High Cytoplasmic CXCR4 Expression Predicts Prolonged Survival in Triple-Negative Breast Cancer Patients Treated with Adjuvant Chemotherapy
Authors: Bobae Shim, Min‐Sun Jin, Ji Hye Moon, In Ae Park, Han Suk Ryu
Journal of Pathology and Translational Medicine
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SDF1α/CXCR4 axis may be associated with the malignant progression of gastric cancer in the hypoxic tumor microenvironment
Authors: Masakazu Yashiro, Haruhito Kinoshita, Gen Tsujio, Tatsunari Fukuoka, Yurie Yamamoto, Tomohiro Sera et al.
Oncology Letters
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Prognostic value of stromal cell‐derived factor 1 expression in patients with gastric cancer after surgical resection
Authors: Xuefei Wang, Heng Zhang, Hongyong He, Zhenbin Shen, Zhaoqing Tang, Jiejie Xu et al.
Cancer Science
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NF‐ kappa B ‐inducing kinase is a key regulator of inflammation‐induced and tumour‐associated angiogenesis
Authors: Ae R Noort, Katinka P M van Zoest, Ester M Weijers, Pieter Koolwijk, Chrissta X Maracle, Deborah V Novack et al.
The Journal of Pathology
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Expression of stromal cell-derived factor-1 alpha is an independent risk factor for lymph node metastasis in early gastric cancer
Authors: IK-CHAN SONG, ZHE-LONG LIANG, JUNG-CHAN LEE, SONG-MEI HUANG, HA-YON KIM, YOON-SUK OH et al.
Oncology Letters
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Epithelial and Stromal Characteristics of Primary Tumors Predict the Bone Metastatic Subtype of Prostate Cancer and Patient Survival after Androgen-Deprivation Therapy
Authors: Pernilla Wikström, Sofia Halin Bergström, Andreas Josefsson, Julius Semenas, Annika Nordstrand, Elin Thysell et al.
Cancers (Basel)
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Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function
Authors: Irene Mariam Roy, P.V. Anu, Samantha Zaunz, Srinu Reddi, Aravind M. Giri, Rithika Saroj Sankar et al.
iScience
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CXCL 12 expression in intrahepatic cholangiocarcinoma is associated with metastasis and poor prognosis
Authors: Tatsunori Miyata, Yo‐Ichi Yamashita, Tomoharu Yoshizumi, Masayuki Shiraishi, Masayuki Ohta, Susumu Eguchi et al.
Cancer Science
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Difference in CXCR4 expression between sporadic and VHL-related hemangioblastoma
Authors: Roeliene C. Kruizinga, Denise M. S. van Marion, Wilfred F. A. den Dunnen, Jan C. de Groot, Eelco W. Hoving, Sjoukje F. Oosting et al.
Familial Cancer
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Inhibition of stromal CXCR4 impairs development of lung metastases
Authors: Crescenzo D’Alterio, Antonio Barbieri, Luigi Portella, Giuseppe Palma, Marianeve Polimeno, Anna Riccio et al.
Cancer Immunology, Immunotherapy
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Evaluation of the combined expression of chemokine SDF-1 alpha and its receptor CXCR4 as a prognostic marker for gastric cancer
Authors: HYO JIN LEE, SONG MEI HUANG, HA YON KIM, YOON SUK OH, JI YOUNG HWANG, ZHE LONG LIANG et al.
Experimental and Therapeutic Medicine
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Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes
Authors: Jiang Z, Li H, Schroer SA et al.
The EMBO journal
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CXCR4 Regulates Temporal Differentiation via PRC1 Complex in Organogenesis of Epithelial Glands
Authors: J Kim, SW Lee, K Park
International Journal of Molecular Sciences, 2021-01-10;22(2):.
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In the ovine pituitary, CXCR4 is localized in gonadotropes and somatotropes and increases with elevated serum progesterone
Authors: N.S. Sanchez, K.E. Quinn, A.K. Ashley, R.L. Ashley
Domestic Animal Endocrinology
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Correlation between CXCR4/CXCR7/CXCL12 chemokine axis expression and prognosis in lymph-node-positive lung cancer patients
Authors: Katsura M, Shoji F, Okamoto T et al.
Cancer Sci.
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The Vaccine-site Microenvironment Induced by Injection of Incomplete Freund's Adjuvant, With or Without Melanoma Peptides
Authors: Rebecca C. Harris, Kimberly A. Chianese-Bullock, Gina R. Petroni, Jochen T. Schaefer, Louis B. Brill, Kerrington R. Molhoek et al.
Journal of Immunotherapy
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Inhibitor and activator: dual functions for SHIP in immunity and cancer
Authors: William G. Kerr
Annals of the New York Academy of Sciences
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Epitope retrieval: Leica BOND ER2 (high-pH) 100C 40min
Primary Ab: 5ug/mL in BSA/TBS for 30min
Detection system: Leica BOND-RX autostainer with Leica BOND refine detection kit
1:100
Citrate buffer antigen retrieval
FFPE tissues