Human/Mouse CXCR7/RDC-1 APC-conjugated Antibody Summary
Accession # P25106
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of CXCR7/RDC‑1 in MCF‑7 Human Cell Line by Flow Cytometry. MCF-7 human breast cancer cell line was stained with Mouse Anti-Human/Mouse CXCR7/RDC-1 APC-conjugated Mono-clonal Antibody (Catalog # FAB4227A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: CXCR7/RDC-1
The G protein-coupled receptor, RDC1, belongs to a subgroup of chemokine receptors and has been designated CXCR7. CXCR7 can bind with high-affinity to CXCL12/SDF-1 and CXCL11/I‑TAC. It is also a co-receptor for several HIV and SIV strains. In their N-termini and extracellular loops 1, 2, and 3, human and mouse CXCR7 share 84%, 100%, 96%, and 86% amino acid sequence identity, respectively. Reports of mRNA levels and/or protein expression (as assessed using anti-CXCR7, clone 9C4) (J. Biol. Chem. 2005, 280(42):35760, J. Immunol. 2006, 176(4):2197) indicate that CXCR7 occurs on a wide variety of tissues and cells including monocytes, B cells, T cells and mature dendritic cells. In contrast, based on ligand binding analysis and receptor level (as assessed using anti-CXCR7, clone 11G8), surface expression of CXCR7 was reported to be restricted to tumor cells, activated endothelial cells, fetal liver cells, and few other cell types (J. Exp. Med. 2006, 203(9):2201). The basis of these inconsistent observations is not known but may be attributed to cell context and the use of different antibodies that may recognize different epitopes.
Product Datasheets
Citations for Human/Mouse CXCR7/RDC-1 APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 8
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Disulfide bond replacement with non-reducible side chain to tail macrolactamization for the development of potent and selective CXCR4 peptide antagonists endowed with flanking binding sites
Authors: Trotta, AM;Tomassi, S;Di Maiolo, G;Ieranò, C;Vetrei, C;D'Alterio, C;Merlino, F;Messere, A;D'Aniello, A;Del Bene, A;Mazzarella, V;Roggia, M;Natale, B;Cutolo, R;Campagna, E;Mottola, S;Russo, R;Chambery, A;Benedetti, R;Altucci, L;Cosconati, S;Scala, S;Di Maro, S;
European journal of medicinal chemistry
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Breast Cancer: An Examination of the Potential of ACKR3 to Modify the Response of CXCR4 to CXCL12
Authors: I Del Molino, GC Wilkins, A Meeson, S Ali, JA Kirby
Int J Mol Sci, 2018-11-14;19(11):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Role of CXCL13 and CCL20 in the recruitment of B cells to inflammatory foci in chronic arthritis
Authors: E Armas-Gonz, MJ Domínguez-, A Díaz-Martí, M Arce-Franc, J Castro-Her, G Danelon, V Hernández-, S Bustabad-R, A Cantabrana, M Uguccioni, F Díaz-Gonzá
Arthritis Res. Ther., 2018-06-07;20(1):114.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Mutational Analysis of Atypical Chemokine Receptor 3 (ACKR3/CXCR7) Interaction with its Chemokine Ligands CXCL11 and CXCL12
Authors: Nikolaus Heveker
J. Biol. Chem., 2016-11-14;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Downregulation of CXCL12 in mesenchymal stromal cells by TGF? promotes breast cancer metastasis
Oncogene, 2016-09-26;0(0):.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
CXCR4 expression on pathogenic T cells facilitates their bone marrow infiltration in a mouse model of aplastic anemia.
Authors: Arieta Kuksin C, Gonzalez-Perez G, Minter L
Blood, 2015-02-03;125(13):2087-94.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Llama-derived single variable domains (nanobodies) directed against chemokine receptor CXCR7 reduce head and neck cancer cell growth in vivo.
Authors: Maussang D, Mujic-Delic A, Descamps F, Stortelers C, Vanlandschoot P, Stigter-van Walsum M, Vischer H, van Roy M, Vosjan M, Gonzalez-Pajuelo M, van Dongen G, Merchiers P, van Rompaey P, Smit M
J Biol Chem, 2013-08-26;288(41):29562-72.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
CXCR7 protein is not expressed on human or mouse leukocytes.
Authors: Berahovich RD, Zabel BA, Penfold ME, Lewen S, Wang Y, Miao Z, Gan L, Pereda J, Dias J, Slukvin II, McGrath KE, Jaen JC, Schall TJ
J. Immunol., 2010-10-01;185(9):5130-9.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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