Human/Mouse/Rat CCR5 APC-conjugated Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of CCR5 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD3e Alexa Fluor® 405-conjugated Monoclonal Antibody (Catalog # FAB100V) and either (A) Mouse Anti-Human/Mouse/Rat CCR5 APC-conjugated Monoclonal Antibody (Catalog # FAB1802A) or (B) Mouse IgG1Allophycocyanin Isotype Control (Catalog # IC002A). View our protocol for Staining Membrane-associated Proteins.
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Detection of CCR5 in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes treated with anti-CD3, anti-CD28, 5 ng/mL Recombinant Mouse IL-12 (Catalog # 419-ML) and 10 µg/mL Goat Anti-Mouse IL-4 Poly-clonal Antibody (Catalog # AB-404-NA) to induce Th1 development for 3 days were stained with Mouse Anti-Human/Mouse/Rat CCR5 APC-conjugated Monoclonal Antibody (Catalog # FAB1802A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Detection of CCR5 in Rat Splenocytes by Flow Cytometry. Rat splenocytes were stained with Mouse Anti-Human/Mouse/Rat CCR5 APC-conjugated Monoclonal Antibody (Catalog # FAB1802A) and Anti-Rat CD3 PE-conjugated Antibody. Quadrant markers were set based on control antibody staining (Catalog # IC002A). View our protocol for Staining Membrane-associated Proteins.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: CCR5
CCR5 is a G protein-linked seven transmembrane domain chemokine receptor. CCR5 serves as a receptor for several chemokines including MIP-1 alpha, MIP-1 beta, MCP-2, and RANTES. It also functions as a coreceptor for Macrophage Tropic HIV-1 infection.
Product Datasheets
Citations for Human/Mouse/Rat CCR5 APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Physical Exercise Reduces the Expression of RANTES and Its CCR5 Receptor in the Adipose Tissue of Obese Humans
Authors: Engin Baturcam, Jehad Abubaker, Ali Tiss, Mohamed Abu-Farha, Abdelkrim Khadir, Fahad Al-Ghimlas et al.
Mediators of Inflammation
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Chemokine Receptor CCR7 Triggers an Endomembrane Signaling Complex for Spatial Rac Activation
Authors: JM Laufer, MA Hauser, I Kindinger, V Purvanov, A Pauli, DF Legler
Cell Rep, 2019-10-22;29(4):995-1009.e6.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
CCR5 governs DNA damage and breast cancer stem cell expansion
Authors: X Jiao, MA Velasco-Ve, M Wang, Z Li, H Rui, AR Peck, JE Korkola, X Chen, S Xu, JB DuHadaway, S Guerrero-R, S Addya, D Sicoli, Z Mu, G Zhang, A Stucky, X Zhang, M Cristofani, A Fatatis, JW Gray, JF Zhong, GC Prendergas, RG Pestell
Cancer Res., 2018-01-22;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
CIB1 and CIB2 are HIV-1 helper factors involved in viral entry
Sci Rep, 2016-08-04;6(0):30927.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
CCR5 receptor antagonists block metastasis to bone of v-Src oncogene-transformed metastatic prostate cancer cell lines.
Authors: Sicoli D, Jiao X, Ju X, Velasco-Velazquez M, Ertel A, Addya S, Li Z, Ando S, Fatatis A, Paudyal B, Cristofanilli M, Thakur M, Lisanti M, Pestell R
Cancer Res, 2014-12-01;74(23):7103-14.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
IL-27 in human secondary lymphoid organs attracts myeloid dendritic cells and impairs HLA class I-restricted antigen presentation.
Authors: Morandi, Fabio, Di Carlo, Emma, Ferrone, Soldano, Petretto, Andrea, Pistoia, Vito, Airoldi, Irma
J Immunol, 2014-02-19;192(6):2634-42.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
CCR5 antagonist blocks metastasis of basal breast cancer cells.
Authors: Velasco-Velazquez M, Jiao X, De la Fuente M, Pestell T, Ertel A, Lisanti M, Pestell R
Cancer Res, 2012-05-25;72(15):3839-50.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
HIV-1 infection is characterized by profound depletion of CD161+ Th17 cells and gradual decline in regulatory T cells.
Authors: Prendergast A, Prado JG, Kang YH, Chen F, Riddell LA, Luzzi G, Goulder P, Klenerman P
AIDS, 2010-02-20;24(4):491-502.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4+CD25+ regulatory T cells.
Authors: Bayry J, Triebel F, Kaveri SV, Tough DF
J. Immunol., 2007-04-01;178(7):4184-93.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy
Authors: Xuanmao Jiao, Min Wang, Zhao Zhang, Zhiping Li, Dong Ni, Anthony W. Ashton et al.
Breast Cancer Research
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