Human/Mouse/Rat CTGF/CCN2 Antibody Summary
Glu247-Ala349
Accession # P29279
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Human, Mouse, and Rat CTGF/CCN2 by Western Blot. Western blot shows lysates of HUVEC human umbilical vein endothelial cells, SVEC4-10 mouse vascular endothelial cell line, and Rat-2 rat embryonic fibroblast cell line. PVDF membrane was probed with 2 µg/mL of Rabbit Anti-Human/Mouse/Rat CTGF/CCN2 Monoclonal Antibody (Catalog # MAB91901) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # HAF008). A specific band was detected for CTGF/CCN2 at approximately 36 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CTGF/CCN2
CTGF belongs to the CCN (CYR61/CTGF/NOV) family of secreted proteins that share a common multimodular organization. Each protein contains IGF-binding protein domain, a von Willebrand factor type C domain, a thrombospondin type I domain, and a cysteine knot domain. The multimodular CTGF has the ability to bind multiple ligands and has numerous effects on development, differentation, and disease. The C-terminal cysteine knot motif contains the heparin and low density lipoprotein receptor (LDLR) binding sites that contributes to the adhesive and mitogenic properties of CTGF.
Product Datasheets
Citations for Human/Mouse/Rat CTGF/CCN2 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 2
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Geniposide ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting TGF-?/Smad and p38MAPK signaling pathways
Authors: Yin, JB;Wang, YX;Fan, SS;Shang, WB;Zhu, YS;Peng, XR;Zou, C;Zhang, X;
PloS one
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme
Authors: G Jacquemin, A Wurmser, M Huyghe, W Sun, Z Homayed, C Merle, M Perkins, F Qasrawi, S Richon, F Dingli, G Arras, D Loew, D Vignjevic, J Pannequin, S Fre
Elife, 2022-05-11;11(0):.
Species: Mouse
Sample Types: Organoids
Applications: Neutralization
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