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Human/Mouse/Rat FKBP13 Antibody

Catalog #: MAB4356
3 Citations 2 Reviews Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB4356
MAB4356-SP
Detection of Human and Rat FKBP13 by Western Blot.
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Product Details
Citations (3)
FAQs
Supplemental Products
Reviews (2)
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human/Mouse/Rat FKBP13 Antibody Summary

Species Reactivity
Human, Mouse, Rat
Specificity
Detects endogenous human, mouse, and rat FKBP13 at 13 kDa in Western blots. In Western blots, this antibody does not cross-react with recombinant human FKBP12, FKBP12.6, FKBP25, FKBP38, FKBP51, or FKBP52.
Source
Monoclonal Rat IgG2B Clone # 422617
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
E. coli-derived recombinant human FKBP13
Ala22-Leu142
Accession # P26885
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Human and Rat FKBP13 antibody by Western Blot. View Larger

Detection of Human and Rat FKBP13 by Western Blot. Western blot shows lysates of MCF-7 human breast cancer cell line, PC-12 rat adrenal pheochromocytoma cell line, and Rat-2 rat embryonic fibroblast cell line. PVDF membrane was probed with 1 µg/mL of Human/Mouse/Rat FKBP13 Monoclonal Antibody (Catalog # MAB4356) followed by HRP-conjugated Anti-Rat IgG Secondary Antibody (Catalog # HAF005). A specific band was detected for FKBP13 at approximately 13 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: FKBP13

FK506 binding protein, 13 kDa molecular weight (FKBP13), also called FKBP2, is a peptidyl-prolyl isomerase that catalyzes the transition between cis- and trans-proline residues critical for proper folding of proteins. The macrolide immunosuppressant FK506 is a potent FKBP13 inhibitor. FKBP13 is strongly induced by calcium ionophores and agents that cause endoplasmic reticulum stress, such as tunicamycin. FKBP13 is membrane-associated and tightly bound to the cytoskeletal protein Band 4.1 in erythrocytes, suggesting a role in maintaining structural proteins.

Long Name
13 kDa FK506 Binding Protein
Entrez Gene IDs
2286 (Human); 14227 (Mouse); 25639 (Rat)
Alternate Names
EC 5.2.1.8,13 kDa FK506-binding protein; FK506 binding protein 2, 13kDa; FK506-binding protein 2 (13kD); FK506-binding protein 2; FKBP13; FKBP13,13 kDa FKBP; FKBP-13proline isomerase; FKBP2; FKBP-2; Immunophilin FKBP13; peptidyl-prolyl cis-trans isomerase FKBP2; PPIase FKBP2; PPIase; rapamycin-binding protein; rotamase

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Citations for Human/Mouse/Rat FKBP13 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

3 Citations: Showing 1 - 3
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  1. Extensive SUMO Modification of Repressive Chromatin Factors Distinguishes Pluripotent from Somatic Cells
    Authors: I Theurillat, IA Hendriks, JC Cossec, A Andrieux, ML Nielsen, A Dejean
    Cell Rep, 2020-09-15;32(11):108146.
  2. Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency
    Authors: C Hernandez, Z Wang, B Ramazanov, Y Tang, S Mehta, C Dambrot, YW Lee, K Tessema, I Kumar, M Astudillo, TA Neubert, S Guo, NB Ivanova
    Cell Stem Cell, 2018-08-23;0(0):.
  3. Maternal Dppa2 and Dppa4 are dispensable for zygotic genome activation but important for offspring survival
    Authors: Oana Kubinyecz, Fatima Santos, Deborah Drage, Wolf Reik, Melanie A. Eckersley-Maslin
    Development

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Reviews for Human/Mouse/Rat FKBP13 Antibody

Average Rating: 3.5 (Based on 2 Reviews)

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Human/Mouse/Rat FKBP13 Antibody
By Anonymous on 03/11/2019
Application: Microarrays Sample Tested: EDTA Plasma Species: Human
Other Human/Mouse/Rat FKBP13 Antibody MAB4356
Human/Mouse/Rat FKBP13 Antibody
By Anonymous on 02/21/2019
Application: MiAr Sample Tested: EDTA Plasma Species: Human