Human/Mouse/Rat FKBP38 Antibody Summary
Met58-Gly382
Accession # Q14318
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Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Human/Mouse/Rat FKBP38 by Western Blot. Western blot shows lysates of HepG2 human hepatocellular carcinoma cell line, NIH-3T3 mouse embryonic fibroblast cell line, and L6 rat myoblast cell line. PVDF membrane was probed with 0.5 µg/mL of Human/Mouse/Rat FKBP38 Monoclonal Antibody (Catalog # MAB3580) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for FKBP38 at approximately 60 to 64 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 2.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: FKBP38
FK506 Binding Proteins (FKBPs) are intracellular receptors for the immuno-suppressive drug FK506. The FKBP/FK506 complex exerts its immunosuppressive effects by inhibiting calcineurin, a calcium- and calmodulin-dependent serine/threonine phosphatase that functions as a critical signaling molecule during T-cell activation. FKBP38, also known as FKBP8, is a 355 to 412 amino acid (aa) protein with an apparent molecular mass of ~60‑64 kDa in SDS-PAGE. FKBP38 binds to and inhibits calcineurin even in the absence of FK506, indicating that FKBP38 is a constitutively active inhibitor of calcineurin. Additionally, FKBP38 co‑immunoprecipitates with Bcl-2 and Bcl-xL, suggesting that FKBP38 may regulate apoptosis by anchoring Bcl‑2 and Bcl‑xL to mitochondrial membranes. Mouse FKBP38 shares 94% and 87% sequence identity with human and rat FKBP38, respectively.
Product Datasheets
Citations for Human/Mouse/Rat FKBP38 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Macrocycles that inhibit the binding between heat shock protein 90 and TPR-containing proteins.
Authors: Ardi V, Alexander LD, Johnson VA et al.
ACS Chem Biol
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Adding Fingers to an Engineered Zinc Finger Nuclease Can Reduce Activity.
Authors: Shimizu Y, Sollu C, Meckler JF et al.
Biochemistry;50(22):5033-5041.
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ZMYND10 functions in a chaperone relay during axonemal dynein assembly.
Authors: Mali GR, YeYati PL, Mizuno S et al.
Elife.
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Non-integrating gamma-retroviral vectors as a versatile tool for transient zinc-finger nuclease delivery.
Authors: Bobis-Wozowicz S, Galla M, Alzubi J et al.
Sci Rep
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Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species
Authors: Yamashita, SI;Sugiura, Y;Matsuoka, Y;Maeda, R;Inoue, K;Furukawa, K;Fukuda, T;Chan, DC;Kanki, T;
Cell death and differentiation
Species: Human
Sample Types:
Applications: Western Blot -
Exchange protein directly activated by cAMP 2 is required for corticotropin‐releasing hormone‐mediated spine loss
Authors: Zhong Xie, Peter Penzes, Deepak P. Srivastava
European Journal of Neuroscience
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A Serotonin Circuit Acts as an Environmental Sensor to Mediate Midline Axon Crossing through EphrinB2
Authors: Lingyan Xing, Jong-Hyun Son, Tamara J. Stevenson, Christina Lillesaar, Laure Bally-Cuif, Tiffanie Dahl et al.
The Journal of Neuroscience
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Phosphatidic Acid Activates Mammalian Target of Rapamycin Complex 1 (mTORC1) Kinase by Displacing FK506 Binding Protein 38 (FKBP38) and Exerting an Allosteric Effect.
Authors: Yoon MS, Sun Y, Arauz E
J. Biol. Chem., 2011-07-07;286(34):29568-74.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
A novel zinc-finger nuclease platform with a sequence-specific cleavage module.
Authors: Schierling B, Dannemann N, Gabsalilow L et al.
Nucleic Acids Research.
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Selection-independent generation of gene knockout mouse embryonic stem cells using zinc-finger nucleases.
Authors: Osiak A, Radecke F, Guhl E et al.
PLoS ONE 6(12).
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