Human/Mouse/Rat FRS2 Antibody Summary
Asn121-Asn449
Accession # Q8WU20
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Human/Mouse/Rat FRS2 by Western Blot. Western blot shows lysates of MCF-7 human breast cancer cell line, C2C12 mouse myoblast cell line, and PC-12 rat adrenal pheochromocytoma cell line. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse/Rat FRS2 Monoclonal Antibody (Catalog # MAB4069) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for FRS2 at approximately 85 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: FRS2
FRS2 (FGF R substrate 2; also known as SNT and FRS2 alpha ) is a 70‑90 kDa member of the FRS family of lipid-anchored docking proteins. It is an intermediary between FGF R and other RTK receptors and their Ras/MAPK signaling cascades. FRS2 contains a membrane-anchoring myristoylation signal (aa 1‑6), a PTB domain (aa 13‑115) that interacts with FGF and NGF receptors, and a C-terminal Tyr-rich region (aa 196‑471) that serves as a docking site for GRB‑2 and SHP‑2.
Product Datasheets
Citations for Human/Mouse/Rat FRS2 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
12
Citations: Showing 1 - 10
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FGF19 functions as autocrine growth factor for hepatoblastoma
Authors: David J. Elzi, Meihua Song, Barron Blackman, Susan T. Weintraub, Dolores López-Terrada, Yidong Chen et al.
Genes & Cancer
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Tackling FGFR3-driven bladder cancer with a promising synergistic FGFR/HDAC targeted therapy
Authors: Zechen Wang, Viswanathan Muthusamy, Daniel P. Petrylak, Karen S. Anderson
npj Precision Oncology
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Inhibition of FGF receptor blocks adaptive resistance to RET inhibition in CCDC6-RET–rearranged thyroid cancer
Authors: Renuka Raman, Jacques A. Villefranc, Timothy M. Ullmann, Jessica Thiesmeyer, Viviana Anelli, Jun Yao et al.
Journal of Experimental Medicine
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RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations
Authors: Subbiah, V;Sahai, V;Maglic, D;Bruderek, K;Toure, BB;Zhao, S;Valverde, R;O'Hearn, PJ;Moustakas, DT;Schonherr, H;Gerami-Moayed, N;Taylor, AM;Hudson, BM;Houde, DJ;Pal, D;Foster, L;Gunaydin, H;Ayaz, P;Sharon, DA;Goyal, L;Schram, AM;Kamath, S;Sherwin, CA;Schmidt-Kittler, O;Jen, KY;Ricard, F;Wolf, BB;Shaw, DE;Bergstrom, DA;Watters, J;Casaletto, JB;
Cancer discovery
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Fibroblast growth factor signalling influences homologous recombination-mediated DNA damage repair to promote drug resistance in ovarian cancer
Authors: HA Nicholson, L Sawers, RG Clarke, KJ Hiom, MJ Ferguson, G Smith
British Journal of Cancer, 2022-07-01;0(0):.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer
Authors: S Wu, T Ou, N Xing, J Lu, S Wan, C Wang, X Zhang, F Yang, Y Huang, Z Cai
Nat Commun, 2019-02-12;10(1):720.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Bradykinin B2 Receptor Contributes to Inflammatory Responses in Human Endothelial Cells by the Transactivation of the Fibroblast Growth Factor Receptor FGFR-1
Authors: E Terzuoli, F Corti, G Nannelli, A Giachetti, S Donnini, M Ziche
Int J Mol Sci, 2018-09-06;19(9):.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Gambogenic acid inhibits fibroblast growth factor receptor signaling pathway in erlotinib-resistant non-small-cell lung cancer and suppresses patient-derived xenograft growth
Authors: L Xu, X Meng, N Xu, W Fu, H Tan, L Zhang, Q Zhou, J Qian, S Tu, X Li, Y Lao, H Xu
Cell Death Dis, 2018-02-15;9(3):262.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Renal expression of FGF23 and peripheral resistance to elevated FGF23 in rodent models of polycystic kidney disease.
Authors: Spichtig D, Zhang H, Mohebbi N, Pavik I, Petzold K, Stange G, Saleh L, Edenhofer I, Segerer S, Biber J, Jaeger P, Serra A, Wagner C
Kidney Int, 2014-01-08;85(6):1340-50.
Species: Rat
Sample Types: Tissue Homogenates
Applications: Western Blot -
Phosphorylation and lipid raft association of fibroblast growth factor receptor-2 in oligodendrocytes.
Authors: Bryant MR, Marta CB, Kim FS, Bansal R
Glia, 2009-07-01;57(9):935-46.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Preclinical characterization of bemarituzumab, an anti-FGFR2b antibody for the treatment of cancer
Authors: Hong Xiang, Abigael G. Chan, Ago Ahene, David I. Bellovin, Rong Deng, Amy W. Hsu et al.
mAbs
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circKCNN2 suppresses the recurrence of hepatocellular carcinoma at least partially via regulating miR‐520c‐3p/methyl‐DNA‐binding domain protein 2 axis
Authors: Donghong Liu, Wenbin Liu, Xi Chen, Jianhua Yin, Longteng Ma, Mei Liu et al.
Clinical and Translational Medicine
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