Home / Kirrel3/NEPH2 / Human/Mouse/Rat Kirrel3/NEPH2 Biotin Affinity Purified PAb

Human/Mouse/Rat Kirrel3/NEPH2 Biotin Affinity Purified PAb

Catalog #: BAF4910
5 Citations Datasheet / COA / SDS

Discontinued Product

BAF4910 has been discontinued.
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Citations (5)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human/Mouse/Rat Kirrel3/NEPH2 Biotin Affinity Purified PAb Summary

Species Reactivity
Human, Mouse, Rat
Specificity
Detects Kirrel3/NEPH2 in Western blots. In Western blots, less than 2% cross‑reactivity with recombinant human (rh) Kirrel1 and rhKirrel2 is observed.
Source
Polyclonal Sheep IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Kirrel3/NEPH2
Tyr33-Ala535
Accession # Q8IZU9
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Label
Biotin

Applications

Recommended Concentration
Sample
Western Blot

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Kirrel3/NEPH2

Kirrel3 (Kin of IRRE-like protein 3 precursor; also NEPH2) is a 95-120 kDa member of a small family of podocin binding molecules. Kirrel3 is found on podocytes and olfactory sensory neurons and likely plays a role in cellular adhesion. Kirrel3 is 778 amino acids in length. It is a type I transmembrane (TM) glycoprotein that contains a 514 aa extracellular region (aa 22-535) with five C2 type Ig like domains (aa 48-515) plus a 222 aa cytoplasmic tail. Kirrel3 binds itself as well as nephrin, podocin and ZO-1. Kirrel3 is shed by MMPs, generating a soluble urinary fragment that is 25 kDa smaller than the TM form. Two variant isoforms exist. One has an alternate start site at Met34, while the second shows a 35 aa substitution for aa 566-778. Over aa 1-535, human Kirrel3 is 98% aa identical to mouse Kirrel3.

Long Name
Kin of Irregular Chiasm-like 3
Entrez Gene IDs
84623 (Human); 67703 (Mouse); 315546 (Rat)
Alternate Names
KIAA1867MGC126824; kin of IRRE like 3 (Drosophila); Kin of irregular chiasm-like protein 3; kin of IRRE-like protein 3; KIRRE; Kirrel3; KIRREPRO4502; mKIRRE; MRD4; NEPH2; NEPH2MGC126850; nephrin-like 2; Nephrin-like protein 2

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Citations for Human/Mouse/Rat Kirrel3/NEPH2 Biotin Affinity Purified PAb

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. NDUFS4 regulates cristae remodeling in diabetic kidney disease
    Authors: Mise, K;Long, J;Galvan, DL;Ye, Z;Fan, G;Sharma, R;Serysheva, II;Moore, TI;Jeter, CR;Anna Zal, M;Araki, M;Wada, J;Schumacker, PT;Chang, BH;Danesh, FR;
    Nature communications
    Species: Transgenic Mouse
    Sample Types: Whole Cells
    Applications: MACS
  2. The Transcription Factor ChREBP Links Mitochondrial Lipidomes to Mitochondrial Morphology and Progression of Diabetic Kidney Disease
    Authors: Li, L;Long, J;Mise, K;Poungavrin, N;Lorenzi, PL;Mahmud, I;Tan, L;Saha, PK;Kanwar, YS;Chang, BH;Danesh, FR;
    The Journal of biological chemistry
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Selection
  3. NDUFS4 Regulates Cristae Remodeling in Diabetic Kidney Disease
    Authors: Danesh, F;Mise, K;Long, J;Galvan, D;Ye, Z;Fan, G;Serysheva, I;Moore, T;Wada, J;Schumacker, P;Chang, B;
    Research square
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Isolation
  4. PGC1alpha is required for the renoprotective effect of lncRNA Tug1 in�vivo and links Tug1 with urea cycle metabolites
    Authors: L Li, J Long, K Mise, DL Galvan, PA Overbeek, L Tan, SV Kumar, WK Chan, PL Lorenzi, BH Chang, FR Danesh
    Cell Reports, 2021-08-10;36(6):109510.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  5. Role for carbohydrate response element-binding protein (ChREBP) in high glucose-mediated repression of long noncoding RNA Tug1
    Authors: J Long, DL Galvan, K Mise, YS Kanwar, L Li, N Poungvarin, PA Overbeek, BH Chang, FR Danesh
    J. Biol. Chem., 2020-05-28;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Isolation

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