Human/Mouse/Rat PP2A Catalytic Subunit Antibody Summary
Trp209-Leu309
Accession # P67775
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Human/Mouse/Rat PP2A Catalytic Subunit, by Western Blot. Western blot shows lysates of U937 human histiocytic lymphoma cell line, C2C12 mouse myoblast cell line, and Nb2-11 rat lymphoma cell line. PVDF membrane was probed with 0.1 µg/mL of Human/Mouse/Rat PP2A Catalytic Subunit, Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1653) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # HAF008). A specific band was detected for PP2A Catalytic Subunit, at approximately 36 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: PP2A
Protein Phosphatase 2A (PP2A) is an enzyme that removes phosphates covalently attached to serine and threonine residues in proteins. It contains three subunits; a catalytic subunit C (PP2Ac), an assembly/structural subunit A (PP2Aa), and a regulatory subunit B (PP2Ab). PP2A is a ubiquitous enzyme that plays a role in regulating many cellular activities varying from ion transport in erythrocytes to suppressing tumor growth. Binding of the SV40 small T antigen to the PP2A phosphatase complex is known to cause oncogenic transformation.
Product Datasheets
Citations for Human/Mouse/Rat PP2A Catalytic Subunit Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 2
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Phosphatase inhibition increases AQP2 accumulation in the rat IMCD apical plasma membrane
Authors: Janet D Klein
Am. J. Physiol. Renal Physiol., 2016-08-03;311(6):F1189-F1197.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC -
Calcium/calmodulin-dependent protein kinase II activity regulates the proliferative potential of growth plate chondrocytes.
Authors: Li Y, Ahrens MJ, Wu A, Liu J, Dudley AT
Development, 2011-01-01;138(2):359-70.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot
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