Home / PTP-MEG2 / Human/Mouse/Rat PTP-MEG2 Antibody

Human/Mouse/Rat PTP-MEG2 Antibody

Catalog #: MAB2668
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB2668
MAB2668-SP
Detection of Human/Mouse/Rat PTP-MEG2 by Western Blot.
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Citations (6)
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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human/Mouse/Rat PTP-MEG2 Antibody Summary

Species Reactivity
Human, Mouse, Rat
Specificity
Detects human, mouse, and rat PTP-MEG2.
Source
Monoclonal Mouse IgG2B Clone # 291835
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
E. coli-derived recombinant human PTP-MEG2
Glu2-Gln593
Accession # P43378
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Human/Mouse/Rat PTP-MEG2 antibody by Western Blot. View Larger

Detection of Human/Mouse/Rat PTP-MEG2 by Western Blot. Western blot shows lysates of Raji human Burkitt's lymphoma cell line, TS1 mouse helper T cell line, CTLL-2 mouse cytotoxic T cell line, and Nb2-11 rat lymphoma cell line. PVDF membrane was probed with 1 µg/mL of Human/Mouse/Rat PTP-MEG2 Monoclonal Antibody (Catalog # MAB2668) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for PTP-MEG2 at approximately 68 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: PTP-MEG2

Megakaryocyte protein tyrosine phosphatase 2 (PTP-MEG2), also known as PTPN9, contains an N-terminal domain homologous to the yeast retinaldehyde binding domain Sec14p and a C-terminal phosphatase domain. The Sec14p domain targets PTP-MEG2 to the membrane of secretory vesicles, where it promotes vesicle fusion. Elevated levels of membrane-bound PTP-MEG2 activity in erythroid progenitor cells are observed in polycythemia vera and may affect responsiveness to colony stimulating factors.

Long Name
Megakaryocyte Protein Tyrosine Phosphatase 2
Entrez Gene IDs
5780 (Human); 56294 (Mouse); 266611 (Rat)
Alternate Names
EC 3.1.3.48; MEG2; protein tyrosine phosphatase, non-receptor type 9; Protein-tyrosine phosphatase MEG2; PTPase MEG2; PTPase-MEG2; PTPMEG2; PTP-MEG2; PTPN9; tyrosine-protein phosphatase non-receptor type 9

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Citations for Human/Mouse/Rat PTP-MEG2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

6 Citations: Showing 1 - 6
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  1. Ropivacaine inhibits cervical cancer cell growth via suppression of the miR?96/MEG2/pSTAT3 axis
    Authors: X Chen, W Liu, X Guo, S Huang, X Song
    Oncol. Rep., 2020-02-26;43(5):1659-1668.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  2. MEG2 is regulated by miR-181a-5p and functions as a tumour suppressor gene to suppress the proliferation and migration of gastric cancer cells
    Authors: Z Liu, F Sun, Y Hong, Y Liu, M Fen, K Yin, X Ge, F Wang, X Chen, W Guan
    Mol. Cancer, 2017-07-26;16(1):133.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  3. miR-96 promotes cell proliferation, migration and invasion by targeting PTPN9 in breast cancer
    Sci Rep, 2016-11-18;6(0):37421.
    Species: Human
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  4. The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A
    Authors: Guangpu Li
    J. Biol. Chem., 2016-09-21;291(46):23895-23905.
    Species: Mouse, Rat
    Sample Types: Cell Lysates, Whole Cells
    Applications: ICC, Western Blot
  5. Regulated expression of microRNAs-126/126* inhibits erythropoiesis from human embryonic stem cells.
    Authors: Huang X, Gschweng E, Van Handel B
    Blood, 2010-12-16;117(7):2157-65.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  6. Identification of protein kinase D2 as a pivotal regulator of endothelial cell proliferation, migration, and angiogenesis.
    Authors: Hao Q, Wang L, Zhao ZJ, Tang H
    J. Biol. Chem., 2008-11-09;284(2):799-806.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot

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