Human/Mouse SDPR Antibody Summary
Gly2-Val180
Accession # O95810
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Human and Mouse SDPR by Western Blot. Western blot shows lysates of human heart and mouse lung tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse SDPR Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5759) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for SDPR at approximately 70 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: SDPR
SDPR (Serum deprivation response gene; also SDR and PS-p68) is a 68‑70 kDa member of the PTRF/SDPR family of proteins. It is expressed in striated muscle, platelets, and fibroblasts, and is cytosolic in location. SDPR is known to bind phosphatidylserine and form complexes with both PKC alpha and PTRF, targeting them to caveolae. Human SDPR is 425 amino acids (aa) in length. It contains an N-terminal acetylglycine, three coiled-coil regions (aa 61‑82, 125‑154, and 210‑268), and two serine phosphorylation sites at positions 287 and 293. Over aa 1‑180, human SDPR shares 91% aa identity with mouse SDPR.
Product Datasheets
Citations for Human/Mouse SDPR Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 6
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Molecular Composition and Ultrastructure of the Caveolar Coat Complex
Authors: Alexander Ludwig, Gillian Howard, Carolina Mendoza-Topaz, Thomas Deerinck, Mason Mackey, Sara Sandin et al.
PLoS Biology
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Impaired contractility and detrusor hypertrophy in cavin-1-deficient mice
Authors: Mardjaneh Sadegh Karbalaei, Catarina Rippe, Sebastian Albinsson, Mari Ekman, Alva Mansten, Bengt Uvelius et al.
European Journal of Pharmacology
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Deciphering caveolar functions by syndapin III KO-mediated impairment of caveolar invagination
Authors: E Seemann, M Sun, S Krueger, J Tröger, W Hou, N Haag, S Schüler, M Westermann, CA Huebner, B Romeike, MM Kessels, B Qualmann
Elife, 2017-12-05;6(0):.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
Rosiglitazone drives cavin-2/SDPR expression in adipocytes in a CEBP?-dependent manner
Authors: B Hansson, C Rippe, D Kotowska, S Wasserstro, J Säll, O Göransson, K Swärd, KG Stenkula
PLoS ONE, 2017-03-09;12(3):e0173412.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Injury induced expression of caveolar proteins in human kidney tubules - role of megakaryoblastic leukemia 1
Authors: Krzysztof M. Krawczyk, Jennifer Hansson, Helén Nilsson, Katarzyna K. Krawczyk, Karl Swärd, Martin E. Johansson
BMC Nephrology
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Intermittent Hypoxia Mediates Caveolae Disassembly That Parallels Insulin Resistance Development
Authors: Maider Varela-Guruceaga, Elise Belaidi, Lucie Lebeau, Ella Aka, Ramaroson Andriantsitohaina, Sophie Giorgetti-Peraldi et al.
Frontiers in Physiology
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